Alka-Seltzer Products for Heartburn, Upset Stomach, and Hangover Relief

Medically Reviewed by Beth Johnston, PharmD, BCPS on April 07, 2025
3 min read

Alka-Seltzer products are used to treat symptoms caused by heartburn and upset stomach. The main active ingredients in these products are calcium carbonatecitric acid, and sodium bicarbonate. These ingredients are known as antacids. Antacids work quickly to neutralize the acid in your stomach. This can help relieve symptoms of heartburn, acid indigestion, and sour or upset stomach.

Some Alka-Seltzer products for heartburn and upset stomach may also contain simethicone to help relieve gas and bloating. 

There are Alka-Seltzer products for heartburn and upset stomach for adults and children as young as 12 years old.

There is also an Alka-Seltzer product for hangover relief that can be taken by adults as young as 18 years old. This product contains aspirin, a non-steroidal anti-inflammatory (NSAID), and caffeine. NSAIDs can work to help relieve pain such as headaches or body aches. Caffeine can also help with pain relief as well as keep you awake by stimulating your nervous system.

Check the label on the Alka-Seltzer product you are planning on taking, to make sure you are not allergic to any of the ingredients. 

Do not take more than the recommended dose of Alka-Seltzer. Follow the instructions on the label of the specific Alka-Seltzer product you are taking. If you are on a low salt diet or have high sodium levels, talk to your health care provider about taking an Alka-Seltzer product with sodium bicarbonate or about taking an Alka-Seltzer product for hangover relief, as this may increase the salt levels in your body.

Stop using Alka-Seltzer products for heartburn and upset stomach if you have taken the maximum dose of Alka-Seltzer for 2 weeks, and your symptoms have not improved or gotten worse. 

If you are taking an Alka-Seltzer product for hangover relief, you may be at higher risk of developing Reye’s syndrome (in children and teenagers) and stomach bleeding. Since this product also contains caffeine, you may also experience fast heart beat, irritability, nervousness, and sleeplessness, especially if you eat or drink anything with caffeine in it. Do not use Alka-Seltzer products for more than 2 days for hangover relief unless you are told so by your health care provider. If you experience any of the following while taking Alka-Seltzer for hangover relief, stop taking the medicine and call your health care provider.

  • Dizziness
  • Vomit blood or bloody poop
  • Stomach pain that does not get better
  • Pain that lasts for more than 10 days or gets worse
  • Redness or swelling
  • Ringing of the ears or hearing loss
  • New symptoms occur

Check with a health care provider if you have any of the following before taking an Alka-Seltzer product for hangover relief.

There may be side effects, additional warnings, and interactions with other medicines that are not listed here. These may vary depending on the combination of ingredients in the specific Alka-Seltzer product you are using. Always check the label before taking any Alka-Seltzer product. Talk to a pharmacist or health care provider about your health conditions and other medicines to help determine which Alka-Seltzer products are safe for you.

Use the tables below to help you find the best product to treat your symptoms.

Active Ingredients

  • Calcium carbonate
  • Anhydrous citric acid
  • Sodium bicarbonate
  • Simethicone

Product

Alka-Seltzer Heartburn+Gas ReliefChews

Age

12 years and older

Formulation

Chewable tablets

Dosing Frequency

As symptoms occur

Features

Tropical punch flavor

Product

Alka-Seltzer Extra Strength Heartburn ReliefChews

Age

12 years and older

Formulation

Chewable tablets

Dosing Frequency

As symptoms occur

Features

Fruit flavor

Product

Alka-Seltzer Heartburn Relief Lemon Lime Flavor Effervescent Tablets

Age

12 and older

Formulation

Effervescent Tablets

Dosing Frequency

Every 4 hours as needed

Features

Lemon-lime flavor

Product

Alka-Seltzer Heartburn Relief Extra Strength Effervescent Tablets

Age

12 and older

Formulation

Effervescent Tablets

Dosing Frequency

Every 4 hours as needed

Active Ingredients

  • Aspirin
  • Caffeine

Product

Alka-Seltzer Hangover Relief Effervescent Tablets

Age

18 and older

Formulation

Effervescent Tablets

Dosing 

Every 6 hours as needed