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Overview: Delstrigo contains three medicines in one tablet and is used to treat HIV. It works by helping stop the spread of HIV in your body. Common side effects include dizziness, nausea, and unusual dreams. Delstrigo interacts with many other medicines. Tell your health care provider about all the medicines and supplements you take.

Uses

What is Delstrigo used for?

Delstrigo (doravirine/lamivudine/tenofovir disoproxil fumarate) is commonly used to treat human immunodeficiency virus (HIV).

Delstrigo may also be used for other conditions as determined by your health care provider.

How does Delstrigo work (mechanism of action)?

Delstrigo is a combination of three medicines: doravirine, lamivudine, and tenofovir disoproxil fumarate. Together, they work to help stop the spread of HIV in your body. A lower amount of HIV in your body helps protect and preserve the immune system.

How is Delstrigo supplied (dosage forms)?

Brands and other names

  • Delstrigo

Dosage forms and strengths

  • 100 mg/300 mg/300 mg oral tablets

How should I store Delstrigo?

Delstrigo should be stored tightly closed in the original container at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. The bottle contains a desiccant, which helps protect it from moisture. Do not remove the desiccant. 

Side Effects

What are the most common side effects of Delstrigo?

The most common side effects of Delstrigo are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Dizziness
  • Nausea
  • Unusual dreams

There may be other side effects of Delstrigo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Delstrigo?

While less common, the most serious side effects of Delstrigo are described below, along with what to do if they happen.

Severe Skin Reactions. Delstrigo can cause severe skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), that can lead to death if not treated. If you get a rash, call your health care provider right away. Stop taking Delstrigo and get emergency help if you have a painful rash and any of the following symptoms of SJS or TEN.

  • Painful red or purple skin that looks burned and peels off
  • Flat red rash or blisters on your skin, mouth, nose, and genitals
  • Red, painful, watery eyes
  • Flu-like symptoms, including fever, chills, and muscle aches

Kidney Damage. Kidney damage can happen when taking Delstrigo. Keep all appointments for blood tests to check the health of your kidneys. Call your health care provider right away if you have any of the following symptoms of kidney damage.

  • Reduced need to pee
  • Swelling in your feet, ankles, or legs
  • Weakness or unusual tiredness
  • Difficulty catching your breath or chest pain/pressure
  • Confusion
  • Nausea
  • Seizures

Weak Bones. Using Delstrigo for a long time may cause your bones to become weaker, leading to reduced bone density (osteopenia). It may also cause a more serious condition called osteoporosis, which can cause your bones to break (fracture) more easily. Tell your health care provider if you have any bone pain, muscle pain or weakness, or pain in your hands or feet or if you break a bone. Get a bone mineral density test if one is ordered for you. 

Immune System Changes. When you start Delstrigo, your immune system might get stronger and start fighting infections that have been hiding inside your body for a long time. The type of symptoms you may have will depend on the infection. Tell your health care provider right away if you notice any of the following new symptoms of infection.

  • Fever, sweats, chills, or muscle aches
  • Swollen lymph nodes
  • Vision problems
  • Confusion, problems talking, or headache
  • Skin problems, such as a painful rash or warts
  • Cough or coughing up blood
  • Weakness or coordination problems

Severe Allergic Reactions. Delstrigo may cause allergic reactions, which can be serious. Stop taking Delstrigo and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Delstrigo?

Allergies to Ingredients. People who are allergic to any of the following should not take Delstrigo.

  • Delstrigo
  • Doravirine
  • Lamivudine
  • Tenofovir disoproxil fumarate
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Delstrigo.

Drug Interactions. Delstrigo should not be taken while you are using certain other medicines. Before taking Delstrigo, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Delstrigo before using it?

Do not take Delstrigo unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Delstrigo with other people, even if they have the same condition as you. It may harm them.

Keep Delstrigo out of the reach of children.

Delstrigo may cause dizziness. Do not drive or do other activities that require alertness or coordination until you know how Delstrigo affects you.

It is important to keep all appointments, including for blood tests. This helps your health care provider make sure it is safe for you to take this medicine.

While Delstrigo can help keep the HIV infection under control, it does not cure it. Delstrigo does not help protect against or prevent the spread of sexually transmitted infections (STIs) such as herpes, gonorrhea, or chlamydia.

If you have HIV and hepatitis B, stopping Delstrigo can cause a serious flare-up, or worsening, of your hepatitis B. Your health care provider will test you for hepatitis B before or when starting this medicine. Do not run out of Delstrigo or stop taking it without talking to your health care provider first. If you have HIV and hepatitis B and stop taking Delstrigo, keep all appointments for blood tests so your health care provider can check the health of your liver.

What should I tell my health care provider before using Delstrigo?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Delstrigo is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Liver problems, including hepatitis B
  • Kidney problems
  • Bone problems, including any broken bones

Pregnancy. It is not known if or how Delstrigo could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should take Delstrigo while you are pregnant or trying to get pregnant. If you become pregnant while taking Delstrigo, you can register for the Antiretroviral Pregnancy Registry by calling 800-258-4263 or at www.apregistry.com. This registry collects safety information about the use of HIV medicines during pregnancy.

Breastfeeding. Delstrigo passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Delstrigo while breastfeeding. There may be risks with breastfeeding while taking Delstrigo and having HIV.

How can I get more information about Delstrigo?

For more information about Delstrigo, you can visit the drugmaker’s website at www.delstrigo.com or call them at 877-888-4231. 

Interactions

Does Delstrigo interact with foods or drinks?

There are no known interactions between Delstrigo and foods or drinks.

It is unknown if drinking alcohol will affect Delstrigo. The risk of dizziness may increase if you drink alcohol while taking Delstrigo.

Does Delstrigo interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using Delstrigo.

  • Any medicine for seizures, such as carbamazepine, oxcarbazepine, phenobarbital, or phenytoin
  • Enzalutamide (Xtandi), which is a medicine used for prostate cancer
  • Rifampin (Rifadin) or rifapentine (Priftin), which is a medicine commonly used to treat an infection called tuberculosis
  • Rifabutin (Mycobutin), which is a medicine used to prevent Mycobacterium avium complex infection
  • Mitotane (Lysodren), a medicine used for cancer of the adrenal gland 
  • St. John’s wort, which is a supplement that may be used for depression
  • A nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which is in many prescription and OTC products for pain, swelling, and fever
  • A medicine for viral infections, such as acyclovir, ganciclovir, valacyclovir, or valganciclovir
  • An aminoglycoside antibiotic, such as amikacin or gentamicin, which is a medicine given by injection to treat infections
  • Any other medicine for HIV
  • A medicine for hepatitis C
  • Sorbitol, which may be used as a laxative or a sweetener in certain sugar-free products

Some other medicines may alter the blood levels of Delstrigo. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Delstrigo. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Delstrigo?

If you or someone else has used too much Delstrigo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Delstrigo?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

Missing doses of Delstrigo can cause it to not work as well over time. So it is important not to miss or skip doses.