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Overview: Elrexfio is used to treat multiple myeloma. Common side effects include pain, itching, swelling, or redness near the injection site. Elrexfio is given as an injection under your skin by a healthcare provider in a hospital. Call your healthcare provider or get medical help right away if you get a fever, nausea, tremors, confusion, or trouble breathing, speaking, or walking.

Uses

What is Elrexfio used for?

Elrexfio (elranatamab-bcmm) is commonly used in certain people with multiple myeloma, which is a type of blood cancer.

Elrexfio may also be used for other conditions as determined by your healthcare provider.

How does Elrexfio work (mechanism of action)?

Elrexfio is a medicine that makes your immune system work better to fight multiple myeloma. Elrexfio targets specific immune cells, called T cells, to make them find and attack multiple myeloma cancer cells. T cells kill the cancer cells, which makes your multiple myeloma slow or stop growing.

How is Elrexfio supplied (dosage forms)?

Brands and other names

  • Elrexfio

Dosage forms and strengths

Elrexfio is available in an injectable form that is given by a healthcare provider.

How should I store Elrexfio?

Elrexfio is usually given by a healthcare provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Elrexfio?

The most common side effects of Elrexfio are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Cytokine release syndrome (see below)
  • Tiredness
  • Pain, itching, swelling, bruising, rash, or redness near the injection site
  • Diarrhea and nausea
  • Infection in the nose or throat, sore throat, or common cold symptoms
  • Muscle, joint, or bone pain
  • Pneumonia
  • Reduced appetite
  • Rash
  • Cough
  • Fever
  • Blood disorders (see below)

There may be other side effects of Elrexfio that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Elrexfio?

While less common, the most serious side effects of Elrexfio are described below, along with what to do if they happen.

Severe Allergic Reactions. Elrexfio may cause allergic reactions, which can be serious. Stop using Elrexfio and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Cytokine Release Syndrome. Elrexfio can cause a dangerous and sometimes life-threatening problem called cytokine release syndrome (CRS). CRS occurs when your immune system responds too much to medicines or infection. CRS may happen right away or several days after you get Elrexfio. Get emergency help if you have any of the following symptoms of CRS. 

  • Fever or chills
  • Fast or racing heart
  • Dizziness or feeling lightheaded
  • Trouble breathing
  • Severe nausea, vomiting, or diarrhea
  • Severe headache

Neurologic Problems. Elrexfio can cause a condition called immune effector cell-associated neurotoxicity syndrome (ICANS). Do not drive or do other activities that require alertness or coordination for 48 hours after each of your first three doses of Elrexfio. Also, do not drive, operate heavy machinery, do anything that may be dangerous, and get help right away if you have any of the following symptoms at any time while using this medicine.

  • Headache or dizziness
  • Sleepiness
  • Agitation or confusion
  • Seeing or hearing things that others do not see or hear, also called hallucinations
  • Seizures
  • Balance problems, trouble walking
  • Muscle spasms or shaking
  • Trouble talking, thinking, remembering, or understanding
  • Handwriting changes
  • Pain, numbness, or tingling

Infections. Elrexfio can increase your risk of infections, including serious infections that can lead to death. Call your healthcare provider right away if you have an infection or any of the following symptoms.

  • Burning or stinging when you pee 
  • Sore throat
  • Cough or coughing up blood
  • Feeling very weak and tired
  • Fever, sweats, chills, or muscle aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Weight loss

Blood Disorders. Elrexfio can cause blood disorders, such as low levels of red blood cells (anemia), low levels of neutrophils (neutropenia), low platelet levels (thrombocytopenia). Keep all appointments to have your blood checked. Tell your healthcare provider right away if you have any of the following symptoms of blood disorders.

  • Pale or yellowish skin
  • Easy bruising or bleeding
  • Frequent infection
  • Unusual weakness or tiredness
  • Dizziness, lightheadedness, or feeling like you are about to pass out
  • Headache
  • Fast or abnormal heartbeat
  • Cold hands and feet
  • Fever, chills, or sweats
  • Sore throat, cough, or shortness of breath
  • Mouth or throat sores
  • Swollen lymph nodes

Liver Damage. Liver damage, also called hepatotoxicity, can happen when using Elrexfio. Keep all appointments to have your blood checked. Call your healthcare provider right away if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine (pee)
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Warnings & Precautions

Who should not use Elrexfio?

Allergies to Ingredients. People who are allergic to any of the following should not use Elrexfio.

  • Elrexfio
  • Elranatamab-bcmm
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Elrexfio.

What should I know about Elrexfio before using it?

Elrexfio is usually given by a healthcare provider in a hospital or clinic. You will likely need to stay in the hospital for a day or two after the first few doses to monitor for side effects. 

Your healthcare provider may give you medicines to reduce your risk of side effects from Elrexfio. Examples of these medications include the following.

  • Acetaminophen (Tylenol), which is a medicine used for pain or fever
  • A corticosteroid, such as dexamethasone, which is a medicine for certain inflammatory conditions
  • An antihistamine, such as diphenhydramine (Benadryl), which is a medicine commonly used to treat allergy symptoms

Elrexfio is only available through a special program, from certain pharmacies, and to certain people. It is important that you keep all of your appointments, including labs or other testing, while using Elrexfio. You will be given a wallet card to carry with you as part of this special program. Always carry this card with you and show it to all of your healthcare providers. The wallet card describes side effects you may have from Elrexfio. If you have any questions about this program you can go to www.elrexfiorems.com or call 844-923-7845.

What should I tell my healthcare provider before using Elrexfio?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Elrexfio is right for you.

In particular, make sure that you discuss if you have an infection of any kind.

Other Medicines and Supplements. Elrexfio may interact with other medicines and supplements. Before using Elrexfio, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Elrexfio may cause harm to an unborn baby. You may need a negative pregnancy test before you can start using Elrexfio. Use effective birth control while you are using Elrexfio and for four months after your last dose. Tell your healthcare provider right away if you are or think you may be pregnant.

Breastfeeding. It is not known if Elrexfio passes into breast milk. Do not breastfeed while you are using Elrexfio and for four months after your last dose. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Elrexfio?

For more information about Elrexfio, you can visit the manufacturer’s website at www.elrexfio.com or call them at 800-438-1985.

Interactions

Does Elrexfio interact with foods or drinks?

There are no known interactions between Elrexfio and foods or drinks.

It is unknown if drinking alcohol will affect Elrexfio, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.

Does Elrexfio interact with other medicines (drug interactions)?

Elrexfio may alter the blood levels of some medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

 

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Elrexfio?

If you or someone else has used too much Elrexfio, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Elrexfio?

Elrexfio is usually given by a healthcare provider in a hospital. Your healthcare provider will make sure you are receiving Elrexfio as scheduled.

If you miss an appointment to get your Elrexfio dose, call to make another appointment as soon as possible. 

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