DANSHEN: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Danshen (Salvia bowleyana) is a root commonly used in Traditional Chinese Medicine (TCM). It is often combined with other herbs, such as Panax notoginseng.

Over 35 formulations used in TCM contain danshen. Chemicals in danshen might help with blood thinning. They might also help widen blood vessels, which can improve circulation.

People use danshen for heart disease, high cholesterol, high blood pressure, stroke, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.

Danshen is sometimes called Chinese red sage, Chinese sage, red root safe, and red Sage. Don't confuse this with sage. These are not the same.

Uses & Effectiveness

We currently have no information for DANSHEN overview.

Side Effects

When taken by mouth: Danshen is possibly safe. It's usually well-tolerated. Side effects might include upset stomach, itching, and reduced appetite.

Special Precautions and Warnings

When taken by mouth: Danshen is possibly safe. It's usually well-tolerated. Side effects might include upset stomach, itching, and reduced appetite.

Pregnancy and breast-feeding: There isn't enough reliable information to know if danshen is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Danshen might increase the risk of bleeding. If you have a bleeding disorder, don't use it.

Low blood pressure: Danshen might lower blood pressure. Taking danshen might make blood pressure become too low in people with low blood pressure.

Surgery: Danshen might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using danshen at least 2 weeks before a scheduled surgery.

Interactions

Major Interaction

Do not take this combination

Digoxin (Lanoxin) interacts with DANSHEN
Digoxin helps the heart beat more strongly. Danshen also seems to affect the heart. Taking danshen along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take danshen if you are taking digoxin without talking to your healthcare professional.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DANSHEN
Danshen might slow blood clotting. Taking danshen along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Moderate Interaction

Be cautious with this combination

Warfarin (Coumadin) interacts with DANSHEN
Warfarin is used to slow blood clotting. Danshen might increase how long warfarin stays in the body and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of warfarin might need to be changed.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Midazolam (Versed) interacts with DANSHEN
Midazolam is changed and broken down by the body. Danshen might increase how quickly midazolam is broken down by the body. This might decrease the effects of midazolam.
Medications for high blood pressure (Antihypertensive drugs) interacts with DANSHEN
Danshen might lower blood pressure. Taking danshen along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Aspirin interacts with DANSHEN
Taking danshen along with aspirin might increase how much aspirin is in the blood. This might increase the effects and side effects of aspirin.
Clopidogrel (Plavix) interacts with DANSHEN
Clopidogrel is changed and broken down by the liver. Danshen might decrease how quickly clopidogrel is changed and broken down by the liver. This might increase the effects and side effects of clopidogrel.
Fexofenadine (Allegra) interacts with DANSHEN
Danshen might increase the amount of fexofenadine that gets absorbed by the body. This might increase the amount of fexofenadine in the body, which might increase side effects.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with DANSHEN
Some medications are moved in and out of cells by pumps. Danshen might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Rosuvastatin (Crestor) interacts with DANSHEN
Danshen might increase levels of rosuvastatin in the blood. This might increase the effects and side effects of rosuvastatin.
Amlodipine (Norvasc) interacts with DANSHEN
Taking danshen along with amlodipine might decrease how much amlodipine is in the blood. This might decrease the effects of amlodipine.
Medications changed by the liver (Glucuronidated drugs) interacts with DANSHEN
Some medications are changed and broken down by the liver. Danshen might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Dosing

Danshen has most often been taken by mouth by adults for up to 2 years in a special formulation called compound danshen dripping pills. These pills contain a combination of danshen, Panax nontoginseng, and borneol. Danshen is also sometimes taken by mouth alone or with other ingredients. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

View References

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Sun AY, Zheng P, and Artmann GM. Danshen pretreatment causes pharmacologic and potent resistance to ischemic insult in rat brain. Biorheology 1999;36:73.

Tian, X. H., Xue, W. J., and Ding, X. M. [Application of Danshen injection on early stage of renal transplantation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2005;25(5):404-407. View abstract.

Wang H. Clinical analysis of 40 cases of hyperlipemia treated by acupoint-injection of Danshen. Chinese Acupuncture & Moxibustion (Chung-Kuo Chen Chiu) 1997;17(8):469-470.

Wang, G., Wang, L., Xiong, Z. Y., Mao, B., and Li, T. Q. Compound salvia pellet, a traditional Chinese medicine, for the treatment of chronic stable angina pectoris compared with nitrates: a meta-analysis. Med Sci.Monit. 2006;12(1):SR1-SR7. View abstract.

Wasser, S., Ho, J. M., Ang, H. K., and Tan, C. E. Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats. J Hepatol. 1998;29(5):760-771. View abstract.

Wei, Z. M. [Effects of injection Salviae miltiorrhizae on senile chronic asthmatic bronchitis patients]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;16(7):402-404. View abstract.

Wu, H. L., Wang, X., Li, X. M., Luo, W. J., and Deng, T. T. [Trial study on DENG Tie-tao's coronary heart disease capsules in improving patients' quality of life.]. Chin J Integr.Med 2005;11(3):173-178. View abstract.

Wu, H. N. and Sun, H. [Study on clinical therapeutic effect of composite Salvia injection matched with Western medicine in treating diabetic foot]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(10):727-729. View abstract.

Wu, W., Kuang, P., and Li, Z. Effect of radix Salviae miltiorrhizae on the gene expression of nitric oxide synthase in ischemic rat brains. J Tradit Chin Med 1998;18(2):128-133. View abstract.

Wu, W., Kuang, P., and Li, Z. Protective effect of radix Salviae miltiorrhizae on apoptosis of neurons during focal cerebral ischemia and reperfusion injury. J Tradit Chin Med 1997;17(3):220-225. View abstract.

Wu, Z. G. and Chen, D. Y. 75 cases of coronary artery disease angina pectoris treated by compound Danshan injection and compound Danshan Drop Pill. J Changchun College Tradit Chin Med 2002;18:14.

Wu, Z. Z., Jiang, Y. Q., Yi, S. M., and Xia, M. T. Radix Salviae Miltiorrhizae in middle and late stage glaucoma. Chin Med.J (Engl.) 1983;96(6):445-447. View abstract.

Xia, Z., Gu, J., Ansley, D. M., Xia, F., and Yu, J. Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. J Thorac.Cardiovasc.Surg 2003;126(5):1404-1410. View abstract.

Xiong, L. L. [Therapeutic effect of combined therapy of Salvia miltiorrhizae and Polyporus umbellatus polysaccharide in the treatment of chronic hepatitis B]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(9):533-537. View abstract.

Xu, Z. C. [Effect of injection Salvia miltiorrhizae on peritoneal dialysis]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1993;13(2):74-6, 67. View abstract.

Yi, L. Q. and Wang, X. W. [Comparative study on treatment of severe hepatitis by Western medicine and by TCM]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(7):543-544. View abstract.

York, D. A., Thomas, S., Greenway, F. L., Liu, Z., and Rood, J. C. Effect of an herbal extract Number Ten (NT) on body weight in rats. Chin Med 2007;2:10. View abstract.

Yuan, J., Guo, W., Yang, B., Liu, P., Wang, Q., and Yuan, H. 116 cases of coronary angina pectoris treated with powder composed of radix ginseng, radix notoginseng and succinum. J Tradit.Chin Med 1997;17(1):14-17. View abstract.

Zhai, Z. L., Sun, J. H., and Zhang, J. A large dose of Dan Shen for acute ischaemic stroke. HeBei Medicine 2001;7(12):1110-1111.

Zhang, L. F., Li, L., and Li, J. C. Application of improving microcirculation in treating severe acute pancreatitis. Chin J Practl Intern Med 2002;22:163-164.

Zhang, L. J., Zhang, B. F., and Tian, F. Compound Dan Shen combined with heparin for acute ischaemic stroke. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine 2002;12(7):423.

Zhang, R. J., You, C., Cai, B. W., Wan, Y., He, M., and Li, H. [Effect of compound Salvia injection on blood coagulation in patients with traumatic cerebral infarction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2004;24(10):882-884. View abstract.

Zhang, X. P., Li, Z. J., and Liu, D. R. Progress in research into the mechanism of Radix salviae miltiorrhizae in treatment of acute pancreatitis. Hepatobiliary.Pancreat.Dis Int 2006;5(4):501-504. View abstract.

Zhang, X., Kuang, P., Wu, W., Yin, X., Kanazawa, T., Onodera, K., Metoki, H., and Oike, Y. The effect of radix Salviae Miltiorrhizae Composita on peroxidation of low density lipoprotein due to copper dichloride. J Tradit Chin Med 1994;14(3):195-201. View abstract.

Zhang, X., Wu, W., Kuang, P., Takemichi, K., Kogo, O., Hirobumi, M., and Yasaburo, O. The effect of radix salviae miltiorrhizae composita and ligustrazine on lipid peroxidation in low density lipoprotein due to copper dichloride. J Tradit Chin Med 1994;14(4):292-297. View abstract.

Zhou, S., Shao, W., and Duan, C. [Observation of preventing and treating effect of Salvia miltiorrhiza composita on patients with ischemic coronary heart disease undergoing non-heart surgery]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1999;19(2):75-76. View abstract.

Zhou, W. and Ruigrok, T. J. Protective effect of danshen during myocardial ischemia and reperfusion: an isolated rat heart study. Am J Chin Med 1990;18(1-2):19-24. View abstract.

Bian F, Kang S, Cui H, Wang F, Luan T. The clinical efficacy of compound Danshen injection on acute cerebral infarction and on the changes in the CRP, D-dimer, and IL-6 levels. Am J Transl Res 2021;13(7):8126-8133. View abstract.

Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother 2001;35:501-4. View abstract.

Chan TY. Drug interactions as a cause of overanticoagulation and bleedings in Chinese patients receiving warfarin. Int J Clin Pharmacol Ther 1998;36:403-5. View abstract.

Chow L, Johnson M, Wells A, Dasgupta A. Effect of the traditional Chinese medicines Chan Su, Lu-Shen-Wan, Dan Shen, and Asian ginseng on serum digoxin measurement by Tina-quant (Roche) and Synchron LX system (Beckman) digoxin immunoassays. J Clin Lab Anal 2003;17:22-7. View abstract.

Chu Y, Zhang L, Wang XY, Guo JH, Guo ZX, Ma XH. The effect of Compound Danshen Dripping Pills, a Chinese herb medicine, on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Ethnopharmacol. 2011 Oct 11;137(3):1457-61. View abstract.

Cong S, Dong C, Hu Y, Wang C, Zhang B, Li N. Effect of Salvia miltiorrhiza polyphenolic acid injection on improving limb use and cognitive impairment in patients with acute stroke. Comput Math Methods Med 2022;2022:1481294. View abstract.

Dasgupta, A., Actor, J. K., Olsen, M., Wells, A., and Datta, P. In vivo digoxin-like immunoreactivity in mice and interference of Chinese medicine Danshen in serum digoxin measurement: elimination of interference by using a chemiluminescent assay. Clin Chim.Acta 2002;317(1-2):231-234. View abstract.

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Gao Q, Shen L, Jiang B, et al. Salvia miltiorrhiza-containing Chinese herbal medicine combined with GnRH agonist for postoperative treatment of endometriosis: A systematic review and meta-analysis. Front Pharmacol 2022;13:831850. View abstract.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. View abstract.

Huang H, Li Y, Huang Q, Lei R, Zou W, Zheng Y. Efficacy of compound Danshen Dripping Pills combined with western medicine in the treatment of diabetic retinopathy: a systematic review and meta-analysis of randomized controlled trials. Ann Palliat Med 2021;10(10):10954-10962. View abstract.

Huang J, Tang X, Ye F, He J, Kong X. Clinical therapeutic effects of aspirin in combination with fufang danshen diwan, a traditional Chinese medicine formula, on coronary heart diseases: a systematic review and meta-analysis. Cell Physiol Biochem. 2016;39(5):1955-63. View abstract.

Huang W, Bao Q, Jin, Lian F. Compound danshen dripping pill for treating nonproliferative diabetic retinopathy: a meta-analysis of 13 randomized controlled trials. Evid Based Complement Alternat Med. 2017;2017:4848076. View abstract.

Izzat MB, Yim APC, El-Zufari MH. A taste of Chinese medicine! Ann Thorac Surg 1998;66:941-2. View abstract.

Jia Y, Leung SW. How efficacious is danshen (salvia miltiorrhiza) dripping pill in treating angina pectoris? Evidence assessment for meta-analysis of randomized controlled trials. J Altern Complement Med. 2017 Sep;23(9):676-84. View abstract.

Lai CL, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Han KH, Yuen MF. Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B. Gut. 2014 Jun;63(6):996-1004. View abstract.

Li C, Li Q, Xu J, et al. The efficacy and safety of compound danshen dripping pill combined with percutaneous coronary intervention for coronary heart disease. Evid Based Complement Alternat Med. 2020 Nov 17;2020:5067137. View abstract.

Li Z, Liu M, Chen M, et al. Clinical effect of Danshen decoction in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials. PLoS One 2023;18(5):e0284877. View abstract.

Lian F, Wu L, Tian J, et al. The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: a randomized, double-blind, placebo-controlled multicenter clinical trial. J Ethnopharmacol. 2015 Apr 22;164:71-7. View abstract.

Liu J, Shi Y, Wu C, et al. Comparison of sweated and non-sweated ethanol extracts of Salvia miltiorrhiza Bge. (Danshen) effects on human and rat hepatic UDP-glucuronosyltransferase and preclinic herb-drug interaction potential evaluation. Curr Drug Metab 2022. View abstract.

Liu S, Wang K, Duan X, et al. Efficacy of danshen class injection in the treatment of acute cerebral infarction: A bayesian network meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2019;2019:5814749. View abstract.

Liu Z, Li G, Ma Y, Lin L. The effects of aspirin with combined compound Danshen Dropping Pills on hemorheology and blood lipids in middle-aged and elderly patients with CHD: A systematic review and meta-analysis. Front Public Health 2021;9:664841. View abstract.

Lv C, Liu C, Yao Z, et al. The clinical pharmacokinetics and pharmacodynamics of warfarin when combined with compound danshen: a case study for combined treatment of coronary heart diseases with atrial fibrillation. Front Pharmacol. 2017 Nov 21;8:826. View abstract.

Ma S, Ju W, Dai G, Zhao W, Cheng X, Fang Z, Tan H, Wang X. Synergistic effects of clopidogrel and fufang danshen dripping pills by modulation of the metabolism target and pharmacokinetics. Evid Based Complement Alternat Med. 2014;2014:789142. View abstract.

Ma XJ, Duan WH, Zhang Y, et al. Combination of activating blood circulation and detoxifying Chinese medicines played an anti-inflammatory role in unstable angina patients after percutaneous coronary intervention: A multicenter, open-labeled, randomized controlled trial. Chin J Integr Med 2021;27(11):803-810. View abstract.

Pan LZ, Wang Y, Chen X. A randomized controlled study on an integrated approach to prevent and treat re-adhesion after transcervical resection of moderate-to-severe intrauterine adhesions. Clinics (Sao Paulo) 2021;76:e1987. View abstract.

Qi Y, Yu C, Tang L, Li S, Sun X. Patient characteristics associated with treatment response in patients receiving salvianolate injection for stable angina. J Evid Based Med 2018;11(2):83-8. doi: 10.1111/jebm.12282. View abstract.

Qian X, Tang J, Chu Y, Chen L, Chen Z, Li L. A prospective study of Salvia miltiorrhiza and Rhizoma chuanxiong preparation in the treatment of hypoparathyroidism after total thyroidectomy. Pak J Pharm Sci 2021;34(6(Special)):2385-2389. View abstract.

Qiu F, Jiang J, Ma Y, Wang G, Gao C, Zhang X, Zhang L, Liu S, He M, Zhu L, Ye Y, Li Q, Miao P. Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers. Evid Based Complement Alternat Med. 2013;2013:730734. View abstract.

Qiu F, Wang G, Zhang R, Sun J, et al. Effect of danshen extract on the activity of CYP3A4 in healthy volunteers. Br J Clin Pharmacol 2010;69:656-62. View abstract.

Qiu F, Zeng J, Liu S, He M, Zhu L, Ye Y, Miao P, Shen S, Jiang J. Effects of danshen ethanol extract on the pharmacokinetics of fexofenadine in healthy volunteers. Evid Based Complement Alternat Med. 2014;2014:473213. View abstract.

Roberts AT, Martin CK, Liu Z, et al. The safety and efficacy of a dietary herbal supplement and gallic acid for weight loss. J Med Food. 2007;10:184-8. View abstract.

Shen W, Jin B, Han Y, et al. The effects of Salvia miltiorrhiza on reproduction and metabolism in women with polycystic ovary syndrome: A systematic review and meta-analysis. Evid Based Complement Alternat Med 2021;2021:9971403. View abstract.

Strom BL, Schinnar R, Ziegler EE, et al. Exposure to soy-based formula in infancy and endocrinological and reproductive outcomes in young adulthood. JAMA 2001;286:807-14. View abstract.

Tam LS, et al. Warfarin interacions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995;25:258.

Tan, K. Q., Zhang, C., Liu, M. X., and Qiu, L. [Comparative study on therapeutic effects of acupuncture, Chinese herbs and Western medicine on nervous tinnitus]. Zhongguo Zhen Jiu 2007;27(4):249-251. View abstract.

Van Poppel PC, Breedveld P, Abbink EJ, et al. Salvia miltiorrhiza root water-extract (danshen) has no beneficial effect on cardiovascular risk factors. A randomized double-blind cross-over trial. PLoS One. 2015 Jul 20;10(7):e0128695. View abstract.

Wahed A, Dasgupta A. Positive and negative in vitro interference of Chinese medicine dan shen in serum digoxin measurement. Elimination of interference by monitoring free digoxin concentration. Am J Clin Pathol 2001;116:403-408. View abstract.

Wang CL, Huan N, Wang PL, et al. Guanxin Danshen Dripping Pills Improve Quality of Life and Cardiovascular Prognoses of CHD Patients after PCI with Anxiety or Depression (GLAD Study): A Randomized Double-Blind Placebo-Controlled Study. Chin J Integr Med 2023;29(3):195-204. View abstract.

Wang F, Li L, Xiao H. Analysis of the efficacy and safety of Danshen Dripping pills on the eyes of diabetic retinopathy patients with Qi stagnation and blood stasis. Am J Transl Res 2021;13(11):13059-13066. View abstract.

Wang K, Zhang D, Wu J, Liu S, Zhang X, Zhang B. A comparative study of danhong injection and salvia miltiorrhiza injection in the treatment of cerebral infarction: a systematic review and meta-analysis. Medicine (Baltimore). 2017 Jun;96(22):e70079. View abstract.

Wang N, Luo HW, Niwa M, Ji J. A new platelet aggregation inhibitor from Salvia miltiorrhiza. Planta Med 1989;55:390-1.

Wang T, Fu X, Wang Z. Danshen formulae for cancer: A systematic review and meta-analysis of high-quality randomized controlled trials. Evid Based Complement Alternat Med. 2019;2019:2310639. View abstract.

Wang X, Cheung CM, Lee WY, Or PM, Yeung JH. Major tanshinones of Danshen (Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro. Phytomedicine. 2010 Sep;17(11):868-75. View abstract.

Wang X, Yeung JH. Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine. 2012 Feb 15;19(3-4):348-54. View abstract.

Wen JH, Xiong YQ. The effect of herbal medicine danshensu and ursolic acid on pharmacokinetics of rosuvastatin in rats. Eur J Drug Metab Pharmacokinet. 2011 Dec;36(4):205-11. View abstract.

Wu B, Liu M, Zhang S. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev 2007;(2):CD004295. View abstract.

Wu JR, Liu S, Zhang XM, Zhang B. Danshen injection as adjuvant treatment for unstable angina pectoris: a systematic review and meta-analysis. Chin J Integr Med. 2017 Apr;23(4):306-11. View abstract.

Xie F, Zhang B, Dai S, Jin B, Zhang T, Dong F. Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis. J Ethnopharmacol 2021;281:114346. View abstract.

Xie H, Guo J, Tan B, Wu H. Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2019;98(27):e16339. View abstract.

Xue, Y. P., Zhang, S. B., and Gao, T. [Observation on therapeutic effect of chronic prostatitis treated mainly by warming needle moxibustion]. Zhongguo Zhen Jiu 2006;26(5):335-336. View abstract.

Yang TY, Wei JC, Lee MY, Chen CM, Ueng KC. A randomized, double-blind, placebo-controlled study to evaluate the efficacy and tolerability of Fufang Danshen (Salvia miltiorrhiza) as add-on antihypertensive therapy in Taiwanese patients with uncontrolled hypertension. Phytother Res. 2012 Feb;26(2):291-8. View abstract.

Yao Y, Feng Y, Lin W. Systematic review and meta-analysis of randomized controlled trials comparing compound danshen dripping pills and isosorbide dinitrate in treating angina pectoris. Int J Cardiol. 2015 Mar 1;182:46-7. View abstract.

Yin QS, Chen L, Mi RH, Ai H, Yin JJ, Liu XJ, Wei XD. Efficacy and safety of danshen compound tablets in preventing thalidomide-associated thromboembolism in patients with multiple myeloma: a multicenter retrospective study. Med Sci Monit. 2016 Oct 20;22:3835-42. View abstract.

Yu CM, Chan JC, Sanderson JE. Chinese herbs and warfarin potentiation by danshen. J Intern Med 1997;241:337-9. View abstract.

Zhang H, Han X, Li Y, Li H, Guo X. Effects of danshen tablets on pharmacokinetics of amlodipine in rats. Pharm Biol. 2019;57(1):306-309. View abstract.

Zhang Y, Yang M, Ho NJ, et al. Is it safe to take Radix Salvia Miltiorrhiza - Radix Pueraria Lobate product with warfarin and aspirin? A pilot study in healthy human subjects. J Ethnopharmacol. 2020 Nov 15;262:113151. View abstract.

Zhang Z, Ge B, Zhou L, Lam TN, Zuo Z. Induction of liver cytochrome P450s by Danshen-Gegen formula is the leading cause for its pharmacokinetic interactions with warfarin. J Ethnopharmacol. 2014 Jul 3;154(3):672-86. View abstract.

Zhao X, Wang H, Gao Y, Wang Y. Effects of Compound Danshen Injection combined with magnesium sulfate on pregnancy-induced hypertension syndrome under the guidance of empirical mode decomposition algorithm-based ultrasound image. J Healthc Eng 2021;2021:9026223. View abstract.

Zheng D, Zhang W, Hou M, et al. Evaluation of herb-drug interactions between compound Danshen dripping pills and clopidogrel based on the pharmacokinetics and pharmacodynamics in rats. Biomed Chromatogr. 2023;37(9):e5684. View abstract.

Zhou L, Wang S, Zhang Z, Lau BS, Fung KP, Leung PC, Zuo Z. Pharmacokinetic and pharmacodynamic interaction of Danshen-Gegen extract with warfarin and aspirin. J Ethnopharmacol. 2012 Sep 28;143(2):648-55. View abstract.

Zhou X, Chan K, Yeung JH. Herb-drug interactions with Danshen (Salvia miltiorrhiza): a review on the role of cytochrome P450 enzymes. Drug Metabol Drug Interact. 2012 Mar 2;27(1):9-18. View abstract.

Zhou Y, Wang J, Wang L, Tang J, Zhang C. Effect of compound danshen injection combined with magnesium sulfate on oxidative stress, TNF-a, NO, and therapeutic efficacy in severe preeclampsia. Comput Intell Neurosci. 2022;2022:9789066. View abstract.

Zhu C, Cao H, Zhou X, Dong C, Luo J, Zhang C, Liu J, Ling Y. Meta-analysis of the clinical value of danshen injection and huangqi injection in liver cirrhosis. Evid Based Complement Alternat Med. 2013;2013:842824. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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DANSHEN - Uses, Side Effects, and More

Overview

Uses & Effectiveness

Side Effects

Special Precautions and Warnings

Interactions

Major Interaction

Digoxin (Lanoxin) interacts with DANSHEN

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with DANSHEN

Moderate Interaction

Warfarin (Coumadin) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with DANSHEN

Midazolam (Versed) interacts with DANSHEN

Medications for high blood pressure (Antihypertensive drugs) interacts with DANSHEN

Aspirin interacts with DANSHEN

Clopidogrel (Plavix) interacts with DANSHEN

Fexofenadine (Allegra) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with DANSHEN

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with DANSHEN

Medications moved by pumps in cells (P-Glycoprotein substrates) interacts with DANSHEN

Rosuvastatin (Crestor) interacts with DANSHEN

Amlodipine (Norvasc) interacts with DANSHEN

Medications changed by the liver (Glucuronidated drugs) interacts with DANSHEN

Dosing