Medically Reviewed by Elmer Huerta, MD, MPH on May 15, 2025
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Radiation commonly treats head and neck cancer. The cancer often starts in your: 

  • Throat
  • Mouth
  • Voice box
  • Nasal cavity
  • Other parts of your head and neck 

Radiation therapy damages cancer cell DNA using high-energy rays. Radiation beams often shrink tumors before surgery. And the energy rays can remove any tumors left after surgery, too.

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You’ll go to a hospital or medical center for several weeks. You’ll go often, at a regular time for your external beam radiation therapy:

  • A high-energy beam is directed from outside your body toward your tumor. 
  • The radiation beam shrinks your tumor.

Internal radiation therapy (brachytherapy) can help if your head or neck cancer comes back. With internal radiation: 

  • A capsule or wire contains radioactive material. 
  • Your doctor places the radiation inside your body using a needle or catheter
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Your doctor can focus your radiation therapy to precise spots in your body. They’ll also consider your cancer type. 

Some common spots for head and neck cancer are your:

  • Mouth (inside of it)
  • Throat
  • Sinuses
  • Nasal cavity
  • Voice box (larynx)
  • Salivary glands
  • Thyroid

If you have cancer in your neck lymph nodes, radiation can help. Your doctor can focus the treatments to keep the cancer from spreading.

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The radiation beam delivers a strong dose to your tumor. But the treatment isn’t as strong in nearby healthy tissues. With head and neck cancer, you may get external beam radiation therapy (EBRT) like:

  • A stronger intensity-modulated beam
  • 3D conformal beams to precisely map your tumor
  • Proton therapy may protect your healthy tissues, but it isn't always available.
  • Hyperfractionation, accelerated, or hypofractionation beams to get an exact dose
  • Neutron beam radiation may work, but there's only one facility in the U.S.
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With radiation treatment you may get: 

  • Skin redness
  • Mouth sores
  • Dry mouth or throat
  • Taste changes
  • Mouth or throat pain
  • Jaw stiffness
  • Thick saliva
  • Tooth weakness
  • Fatigue
  • Nosebleeds 
  • Voice changes (hoarseness)

Let your care team know about how you feel. Most symptoms get better after four to eight weeks.

Call your doctor or care team if you have:

  • Fever (100.4 F or higher)
  • Chills
  • Painful, peeling skin
  • Serious nausea or vomiting
  • Medication not helping with pain or constipation
  • Treated area discomfort
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Most radiation side effects don’t last, and many improve after a few weeks. Most symptoms go away after eight weeks. But some radiation side effects can last for years:

  • Swallowing problems
  • Constant dry mouth
  • Thick saliva
  • Speech issues
  • Sinusitis
  • Skin changes
  • Swelling in the face or neck
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About three-quarters of head and neck cancers benefit from radiation. Success depends on where your tumor is at and your cancer stage:

  • Almost 90 in 100 paragangliomas near your ear or neck are cured.
  • About 97 in 100 nasal cavity cancers are cured. 

Talk with your doctor about what your best treatment means for your head and neck cancer.