- Overview
- Symptoms
- Causes & Risks
- Diagnosis
- Types
- Major Depressive Disorder
- Treatment
- Antidepressants
- Treatment-Resistant Depression (TRD)
- Living With
- Recovery & Relapse
- Complications
- Caregiving & Support
- Appointment Prep
- View Full Guide
Understanding Depression Medications


Understanding Depression Medications
Depression medications, or antidepressants, help treat moderate to severe depression. They can be used alone or with talk therapy after a medical diagnosis. By understanding the different types of antidepressants, you can work with your doctor to find the best treatment for your needs.

FDA-Approved Uses for Antidepressants
Antidepressants aren't just for depression. They're also FDA-approved for other mental health conditions, including obsessive-compulsive disorder, social phobia, panic disorder, generalized anxiety disorder, and posttraumatic stress disorder. This means they can be helpful for people dealing with more than one mental health issue.

SSRIs: A Common First Choice
Selective serotonin reuptake inhibitors (SSRIs) are often the standard treatment for depression. Common SSRIs include citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac), and sertraline (Zoloft). These medications help increase serotonin levels in the brain, which can improve mood and emotional well-being.

SNRIs and Other Antidepressants
Serotonin-norepinephrine reuptake inhibitors (SNRIs), such as duloxetine (Cymbalta) and venlafaxine (Effexor), are also commonly prescribed medications. Other options include atypical antidepressants, such as bupropion (Wellbutrin) and mirtazapine (Remeron), and serotonin modulators, such as trazodone and vortioxetine (Trintellix). Each type works differently, so finding the right one may take some time.

MAOIs: Less Common but Important
Monoamine oxidase inhibitors (MAOIs) are less commonly prescribed but can be effective for some people. Examples include phenelzine (Nardil) and tranylcypromine (Parnate). These medications require careful monitoring due to potential side effects and interactions with certain foods and other medications.

Choosing the Right Medication
Your doctor will likely start with an SSRI and change it based on how you respond. It's important to communicate openly about your symptoms and any side effects. Finding the right medication can take time, but with patience and teamwork, you can find a treatment that helps you feel better.

Empowering Yourself With Knowledge
Knowing about the different types of antidepressants can help you have informed discussions with your doctor. Understanding your options and how these medications work can empower you to take an active role in your treatment and improve your mental health.
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SOURCES:
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MSD Manual: "Medications for Treatment of Depression."
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