- Overview
- Symptoms
- Causes & Risks
- Diagnosis
- Types
- Major Depressive Disorder
- Treatment
- Antidepressants
- Treatment-Resistant Depression (TRD)
- Living With
- Recovery & Relapse
- Complications
- Caregiving & Support
- Appointment Prep
- View Full Guide
Understanding Unipolar Depression


What Is Unipolar Depression?
Unipolar depression, also known as major depressive disorder, is a mental health condition marked by a consistently low mood and lack of interest in activities.

Common Symptoms
Symptoms of unipolar depression can vary but often include persistent sadness or emptiness, lack of interest in pleasurable activities, irritability, cognitive slowness, and even suicidal thoughts. Recognizing these symptoms early can lead to timely intervention.

Potential Causes
Various factors can contribute to unipolar depression, such as certain genetic makeup, stressful life events like job loss or death of a loved one, and medical conditions like hypothyroidism. Understanding these causes can help in managing the condition.

Diagnosis Process
Diagnosing unipolar depression involves evaluating symptoms and how long they last. Primary care providers can make the first evaluation and refer patients to mental health professionals if needed. There is no specific test for this condition, but thorough evaluation helps ensure accurate diagnosis.

Effective Treatments
Treatment for unipolar depression is often tailored to the individual and can include medications like selective serotonin reuptake inhibitors, drugs that are better known as SSRIs, psychotherapy, and lifestyle changes such as a balanced diet, quality sleep, social interaction, and establishing a daily routine. Combining these approaches supports recovery and improves quality of life.
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SOURCES:
APA Dictionary of Psychology: “Unipolar disorder.”
Cleveland Clinic: “Depression.”
Clinical Psychology Review: “Distinctions between bipolar and unipolar depression.”
Hackensack Meridian Health: “Why Routines are Important for Mental Health.”
Harvard Medical School: “Diet and depression.”
Johns Hopkins Medicine: “Major Depression.”
Journal of Personal and Social Relationships: “The effect of social interaction quantity and quality on depressed mood and loneliness: A daily diary study.”
Mayo Clinic: “Hypothyroidism (underactive thyroid).”
Michigan Medicine: “Unipolar Depression.”
The Lancet Psychiatry: “Use of lithium in patients with unipolar depression.”