5 mins read

Overview: Recombinate is used to treat or prevent certain types of bleeding in people with hemophilia A. It works by replacing a protein called factor VIII, which temporarily helps your blood to clot properly. Common side effects include chills, flushing, rash, and nosebleeds.

Uses

What is Recombinate used for?

Hemophilia A is a condition that causes your blood to not clot properly. Recombinate (antihemophilic factor, recombinant) is commonly used to treat or prevent certain types of bleeding in people with hemophilia A.

Recombinate may also be used for other conditions as determined by your health care provider.

How does Recombinate work (mechanism of action)?

Hemophilia A is caused when your body does not make enough of a certain protein called factor VIII, which normally helps cause your blood to clot. Recombinate works by replacing factor VIII, which temporarily helps your blood to clot properly.

How is Recombinate supplied (dosage forms)?

Recombinate is available in an injectable form in multiple strengths in single-dose vials.

How should I store Recombinate?

Recombinate may be given by a health care provider in a hospital or clinic, or it may be given at home after training by a health care provider. If you will store Recombinate at home, follow the instructions given by your health care provider.

Side Effects

What are the most common side effects of Recombinate?

The most common side effects of Recombinate are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Chills
  • Flushing
  • Rash
  • Nosebleeds

There may be other side effects of Recombinate that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Recombinate?

While less common, the most serious side effects of Recombinate are described below, along with what to do if they happen.

Severe Allergic Reactions. Recombinate may cause allergic reactions, which can be serious. Stop using Recombinate and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Recombinate?

Allergies to Ingredients. People who are allergic to any of the following should not use Recombinate.

  • Antihemophilic factor, recombinant
  • Recombinate
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Recombinate.

Allergy to Cow, Hamster, or Mouse Proteins. Do not use Recombinate if you are allergic to bovine (cow), hamster, or mouse proteins. Tell your health care provider if you are allergic to cows, bovine proteins, hamsters, hamster proteins, mice, or mouse proteins.

What should I know about Recombinate before using it?

Do not use Recombinate unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Recombinate with other people, even if they have the same condition as you. It may harm them.

Keep Recombinate out of the reach of children.

Recombinate may be given by a health care provider in a hospital or clinic, or it may be given at home by yourself or a caregiver after proper training by your health care provider. If you use Recombinate at home, make sure that you or a caregiver understands how to properly prepare, use, and throw away this medicine. Read and follow the instructions that come with the medicine. If you have any questions, talk to your health care provider.

Your health care provider should monitor your blood work while you are being treated with Recombinate. Keep all appointments to have your blood checked.

Some people have an immune system reaction to Recombinate that causes it to stop working as well. This is called neutralizing antibodies or inhibitors. Your health care provider should monitor your immune system with blood tests while you are being treated. Talk to your health care provider if you think Recombinate is not working or if you have been told that you have inhibitors to factor VIII.

What should I tell my health care provider before using Recombinate?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Recombinate is right for you.

In particular, make sure that you discuss any of the following.

Planned Surgery. Tell your health care provider if you have any planned surgeries or procedures.

Pregnancy. It is not known if or how Recombivate could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Recombinate passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Recombinate?

For more information about Recombinate, you can visit the drugmaker’s website at www.recombinate.com or call them at 877-825-3327.

Interactions

Does Recombinate interact with foods or drinks?

There are no known interactions between Recombinate and foods or drinks.

It is unknown if drinking alcohol will affect Recombinate.

Does Recombinate interact with other medicines (drug interactions)?

There are no known interactions between Recombinate and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Recombinate?

If you or someone else has used too much Recombinate, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Recombinate?

If you receive Recombinate from a health care provider in a hospital or clinic, your health care provider will make sure you are receiving it as scheduled. If you miss an appointment to get your Recombinate dose, call to make another appointment as soon as possible.

If you use Recombinate at home and you miss a dose, call your health care provider for instructions. Do not use double or extra doses.