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Overview: Antihemophilic factor recombinant is used to treat or prevent certain types of bleeding in people with hemophilia A. It works by replacing a protein called factor VIII, which temporarily helps your blood to clot properly. Common side effects include feeling unwell, muscle pain, and headache.

Uses

What is antihemophilic factor recombinant used for?

Hemophilia A is a condition that causes your blood to not clot properly. Antihemophilic factor recombinant is commonly used to treat or prevent certain types of bleeding in people with hemophilia A.

Antihemophilic factor recombinant may also be used for other conditions as determined by your health care provider.

How does antihemophilic factor recombinant work (mechanism of action)?

Hemophilia A is caused when your body does not make enough of a certain protein called factor VIII, which normally helps cause your blood to clot. Antihemophilic factor recombinant works by replacing factor VIII, which temporarily helps your blood to clot properly.

How is antihemophilic factor recombinant supplied (dosage forms)?

Brands and other names

  • Advate
  • Adynovate
  • Afstyla
  • Altuviiio
  • Eloctate
  • Esperoct
  • Jivi
  • Kogenate
  • Kovaltry
  • NovoEight
  • Nuwiq
  • Obizur
  • Recombinate
  • Xyntha

How should I store antihemophilic factor recombinant?

Antihemophilic factor recombinant is usually given by a health care provider in a hospital or clinic. Some people use certain forms of antihemophilic factor recombinant at home. If you will store antihemophilic factor recombinant at home, follow the instructions given by your health care provider.

Side Effects

What are the most common side effects of antihemophilic factor recombinant?

The most common side effects of antihemophilic factor recombinant are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • General feeling of being unwell, tired, or not having your usual energy
  • Muscle pain or joint pain
  • Headache
  • Cough
  • Infection in the nose or throat, sore throat, or common cold symptoms
  • Fever, chills
  • Change in how things taste
  • Diarrhea
  • Dizziness
  • Nausea and vomiting
  • Itching
  • Rash, skin bumps
  • Pain, itching, swelling, or redness where the needle entered your skin

There may be other side effects of antihemophilic factor recombinant that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of antihemophilic factor recombinant?

While less common, the most serious side effects of antihemophilic factor recombinant are described below, along with what to do if they happen.

Severe Allergic Reactions. Antihemophilic factor recombinant may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use antihemophilic factor recombinant?

Allergies to Ingredients. People who are allergic to any of the following should not use antihemophilic factor recombinant.

  • Antihemophilic factor recombinant
  • Advate
  • Adynovate
  • Afstyla
  • Altuviiio
  • Eloctate
  • Esperoct
  • Jivi
  • Kogenate
  • Kovaltry
  • NovoEight
  • Nuwiq
  • Obizur
  • Recombinate
  • Xyntha
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in the specific antihemophilic factor recombinant products they stock.

Allergy to Hamster or Mouse Proteins. Do not use certain forms of antihemophilic factor recombinant if you are allergic to hamster or mouse proteins. Tell your health care provider if you are allergic to hamsters, hamster proteins, mice, or mouse proteins.

Congenital Hemophilia A With Inhibitors. Some people with hemophilia A have a certain type of the condition called congenital hemophilia A with inhibitors. This means hemophilia is caused by your genes, and your immune system reacts against factor VIII. Do not use certain forms of antihemophilic factor recombinant if you have this condition. Ask your health care provider if you have congenital hemophilia with inhibitors.

What should I know about antihemophilic factor recombinant before using it?

Do not use antihemophilic factor recombinant unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share antihemophilic factor recombinant with other people, even if they have the same condition as you. It may harm them.

Antihemophilic factor recombinant is usually given by a health care provider in a hospital or clinic. Certain forms may be given at home by yourself or a caregiver. If you use antihemophilic factor recombinant at home, make sure that you or a caregiver understands how to properly prepare and use this medicine. If you have any questions, talk to your health care provider.

Your health care provider should monitor your blood work while you are being treated with antihemophilic factor recombinant. Keep all appointments to have your blood checked.

Some people have an immune system reaction to antihemophilic factor recombinant that causes it to stop working as well. This is called neutralizing antibodies or inhibitors. Your health care provider should monitor your immune system with blood tests while you are being treated. Talk to your health care provider if you think antihemophilic factor recombinant is not working.

What should I tell my health care provider before using antihemophilic factor recombinant?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if antihemophilic factor recombinant is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Planned surgery

Pregnancy. It is not known if or how antihemophilic factor recombinant could affect pregnancy or harm a fetus. Tell your health care provider if you are or plan to become pregnant.

Breastfeeding. It is not known if antihemophilic factor recombinant passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

Interactions

Does antihemophilic factor recombinant interact with foods or drinks?

There are no known interactions between antihemophilic factor recombinant and foods or drinks.

It is unknown if drinking alcohol will affect antihemophilic factor recombinant.

Does antihemophilic factor recombinant interact with other medicines (drug interactions)?

There are no known interactions between antihemophilic factor recombinant and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much antihemophilic factor recombinant?

If you or someone else has used too much antihemophilic factor recombinant, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of antihemophilic factor recombinant?

If you receive antihemophilic factor recombinant from a health care provider in a hospital or clinic, your health care provider will make sure you are receiving it as scheduled. If you miss an appointment to get your antihemophilic factor recombinant dose, call to make another appointment as soon as possible.

If you use antihemophilic factor recombinant at home and you miss a dose, call your health care provider for instructions. Do not take double or extra doses.

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