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Uses

What is Edarbyclor used for?

Edarbyclor (azilsartan/chlorthalidone) is commonly used to lower high blood pressure (hypertension).

Edarbyclor may also be used for other conditions as determined by your healthcare provider.

How does Edarbyclor work (mechanism of action)?

Edarbyclor contains two medicines, azilsartan and chlorthalidone. 

Azilsartan blocks receptors in your body that normally bind to a hormone called angiotensin II. When angiotensin II binds to these receptors, it causes your blood vessels to constrict. Blocking these receptors helps your blood vessels relax so that blood can move through them more easily. 

Chlorthalidone works by increasing how much you pee. It does this by helping the kidneys remove electrolytes, such as sodium (salt), and water from the body. It also appears to allow blood to flow more freely (less resistance to flow).

These effects can help lower blood pressure, and may reduce your risk for heart attack and stroke. 

How is Edarbyclor supplied (dosage forms)?

Edarbyclor is available in the following dosage forms that are taken by mouth.

  • 40 mg/12.5 mg oral tablets
  • 40 mg/25 mg oral tablets

How should I store Edarbyclor?

Edarbyclor should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C), for shorter periods of time, such as when transporting it. Store in a cool, dry place, tightly closed in the original container. Protect from light and moisture.

Side Effects

What are the most common side effects of Edarbyclor?

The most common side effects of Edarbyclor are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Dizziness
  • Tiredness

There may be other side effects of Edarbyclor that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Edarbyclor?

While less common, the most serious side effects of Edarbyclor are described below, along with what to do if they happen.

Low Blood Pressure (Hypotension). Edarbyclor may cause low blood pressure. This can happen especially in people taking a medicine that causes you to pee more often (diuretic). If you feel faint or dizzy, lie down. Tell your healthcare provider right away if you have any of the following symptoms of low blood pressure.

  • Dizziness, feeling lightheaded, or fainting
  • Confusion
  • Feeling weak or tired

Kidney Damage. Kidney damage can happen when taking Edarbyclor. Call your healthcare provider right away if you have any of the following symptoms of kidney damage.

  • Reduced need to pee
  • Swelling in your feet, ankles, or legs
  • Weakness or unusual tiredness
  • Difficulty catching your breath or chest pain/pressure
  • Confusion
  • Nausea
  • Seizures 

Electrolyte Changes and Increased Blood Sugar. Edarbyclor may increase your blood sugar (glucose) levels and cause changes to the levels of certain minerals in your body, called electrolytes. For example, it may cause low potassium levels (hypokalemia), high potassium levels (hyperkalemia), low sodium levels (hyponatremia), low magnesium levels (hypomagnesemia), high calcium levels (hypercalcemia), or low chloride levels (hypochloremia), or high glucose levels (hyperglycemia). These changes can be serious. Your healthcare provider will do bloodwork to check your glucose and electrolyte levels, especially if you take certain other medicines. Keep your appointments to have your blood checked. Call your healthcare provider if you have any of the following symptoms.

  • Weakness
  • Unusual tiredness
  • Muscle cramps or twitching
  • Constipation
  • Nausea, vomiting, or loss of appetite
  • Dizziness
  • Restlessness or irritability
  • Difficulty breathing
  • Confusion or decreased alertness
  • Abnormal heart rhythm
  • Slow heartbeat or feeling of skipped heartbeats
  • Seizures

Severe Allergic Reactions. Edarbyclor may cause allergic reactions, which can be serious. Stop taking Edarbyclor and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Edarbyclor?

Allergies to Ingredients. People who are allergic to any of the following should not take Edarbyclor.

  • Edarbyclor
  • Azilsartan
  • Chlorthalidone
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Edarbyclor.

Drug Interactions. Edarbyclor should not be taken while you are using certain other medicines and you have diabetes. Before taking Edarbyclor, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

No Urine Production. Do not take Edarbyclor if you are making very little to no pee. This condition is also called anuria.

What should I know about Edarbyclor before using it?

Do not take Edarbyclor unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Do not share Edarbyclor with other people, even if they have the same condition as you. It may harm them.

Keep Edarbyclor out of the reach of children.

Edarbyclor can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Edarbyclor affects you.

What should I tell my healthcare provider before using Edarbyclor?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Edarbyclor is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Heart problems 
  • Kidney problems
  • Liver problems
  • Electrolyte imbalance, such as high or low levels of sodium or potassium
  • Persistent or severe vomiting or diarrhea
  • Diabetes
  • Gout
  • Prostate problems
  • A reduced need to pee

Pregnancy. Edarbyclor can cause death or serious harm to an unborn baby if taken during pregnancy. Tell your healthcare provider if you are or plan to become pregnant. If you become pregnant, stop taking Edarbyclor right away and contact your healthcare provider.

Breastfeeding. At least one medicine in Edarbyclor passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take Edarbyclor while breastfeeding.

How can I get more information about Edarbyclor?

For more information about Edarbyclor, you can visit the manufacturer’s website at www.edarbi.com/edarbyclor or call them at 877-495-6858.

Interactions

Does Edarbyclor interact with foods or drinks?

There are no known interactions between Edarbyclor and foods or drinks. However, since Edarbyclor affects electrolytes, it is important to discuss your intake of electrolytes, including sodium and potassium, with your healthcare provider.

It is unknown if drinking alcohol will affect Edarbyclor. The risk of dizziness may be increased if you drink alcohol while taking Edarbyclor. It is best to limit the amount of alcohol you drink.

Does Edarbyclor interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Edarbyclor.

  • Aliskiren (Tekturna), which is a medicine for high blood pressure 
  • A supplement or salt-substitute containing potassium
  • A diuretic, also called a water pill, which is a medicine used to reduce edema (fluid retention) and blood pressure
  • A nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which are contained in many prescription and OTC products for pain, swelling, and fever
  • Lithium, which is a medicine for certain mental health conditions
  • An angiotensin-converting enzyme (ACE) inhibitor, which is a medicine for high blood pressure, heart failure, and certain kidney problems
  • An angiotensin II receptor blocker (ARB), which is a medicine for high blood pressure, heart failure, and other heart conditions
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
  • Any medicine for diabetes
  • Any medicine for high blood pressure 

This may not be a complete list of medicines that can interact with Edarbyclor. Always check with your healthcare provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Edarbyclor?

If you or someone else has used too much Edarbyclor, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Edarbyclor?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.