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Overview: Tybost is used to boost levels of some other medicines for the treatment of HIV. Common side effects include a rash, or your skin or the whites of your eyes turning yellowish in color (jaundice). Tybost interacts with many other medicines. Tell your health care providers about all medicines and supplements you take.

Uses

What is Tybost used for?

Tybost (cobicistat) is commonly used to boost levels of certain other medicines for the treatment of HIV.

Tybost may also be used for other conditions as determined by your health care provider.

How does Tybost work (mechanism of action)?

Tybost boosts levels of certain other HIV medicines, helping them work better. It does not treat HIV on its own. When used with other HIV medicines, Tybost can help stop the spread of HIV in your body. A lower amount of HIV in your body helps protect and preserve the immune system.

How is Tybost supplied (dosage forms)?

Brands and other names

  • Tybost

Dosage forms and strengths

  • 150 mg oral tablets

How should I store Tybost?

Tybost should be stored tightly closed in the original container at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when you’re transporting it. Store it in a cool, dry place.

Side Effects

What are the most common side effects of Tybost?

The most common side effects of Tybost are listed below. These side effects may vary based on which other HIV medicines you are taking with Tybost. Tell your health care provider if you have any of these side effects that bother you.

  • Skin or the whites of your eyes turning yellowish in color (jaundice)
  • Rash

There may be other side effects of Tybost that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Tybost?

While less common, the most serious side effects of Tybost are described below, along with what to do if they happen.

Severe Allergic Reactions. Tybost may cause allergic reactions, which can be serious. Stop taking Tybost and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown, depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Tybost?

Allergies to Ingredients. People who are allergic to any of the following should not take Tybost.

  • Cobicistat
  • Tybost
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Tybost.

Drug Interactions. Tybost should not be taken while you are using certain other medicines. Before taking Tybost, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Tybost before using it?

Do not take Tybost unless it has been prescribed to you by a health care provider. Take it as prescribed

Do not share Tybost with other people, even if they have the same condition as you. It may harm them.

Keep Tybost out of the reach of children.

Take each dose of Tybost with food. Follow your health care provider’s advice about how to take it with your other HIV medicines.

Taking certain acid reducers, such as antacids, H2 blockers, or proton pump inhibitors (PPIs), with Tybost can make it not work as well. Talk with your health care provider about the best way to take acid reducers while taking Tybost.

It is important to keep all appointments with your health care provider, including for lab tests, before starting this medicine and while you are taking it. This helps your health care provider make sure it is safe for you to take this medicine.

When used with other medicines, Tybost can help keep your HIV infection under control, but medicines cannot yet cure HIV. Tybost does not treat HIV if taken by itself. Tybost also does not help protect against or prevent the spread of sexually transmitted infections (STIs), such as chlamydia, gonorrhea, or syphilis.

What should I tell my health care provider before using Tybost?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Tybost is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Liver problems
  • Kidney problems

Pregnancy. It is not known if or how Tybost could affect pregnancy or harm an unborn baby. Tybost is not recommended during pregnancy because it may not work as well (with other medicines) to treat HIV. Tell your health care provider right away if you are pregnant or plan to become pregnant. If you become pregnant while taking Tybost, you can register for the Antiretroviral Pregnancy Registry by calling 800-258-4263 or at www.apregistry.com. This registry collects safety information about the use of HIV medicines during pregnancy.

Breastfeeding. It is not known if Tybost passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. There may be risks with breastfeeding while taking Tybost and having HIV.

How can I get more information about Tybost?

For more information about Tybost, you can visit the drugmaker’s website at www.tybost.com or call them at 800-445-3235.

Interactions

Does Tybost interact with foods or drinks?

There are no known interactions between Tybost and foods or drinks. Tybost should be taken with food.

It is unknown if drinking alcohol will affect Tybost.

Does Tybost interact with other medicines (drug interactions)?

Many medicines interact with Tybost. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Tybost.

  • Alfuzosin, which is a medicine used for trouble peeing due to an enlarged prostate 
  • Ranolazine (Aspruzyo Sprinkle), which is a medicine used for chest pain
  • Dronedarone (Multaq), which is a medicine used to help keep a normal heart rhythm in people who have had atrial fibrillation
  • Any medicine for seizures, such as carbamazepine, phenobarbital, or phenytoin
  • Colchicine, which is a medicine commonly used for gout
  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • A medicine used to treat cancer
  • An antipsychotic, which is a medicine for certain mental health conditions
  • An ergot, such as dihydroergotamine (Migranal, Trudhesa) or ergotamine (Ergomar), which is a medicine used to treat migraine
  • St. John’s wort, which is a supplement that may be used for depression
  • A birth control pill, patch, vaginal ring, implant, injection, or intrauterine device (IUD) that contains hormones
  • A statin, such as atorvastatin (Lipitor and others), lovastatin, rosuvastatin (Crestor), or simvastatin (Zocor), which is a medicine to lower cholesterol
  • Lomitapide (Juxtapid), which is a medicine to lower cholesterol
  • A phosphodiesterase-5 (PDE-5) inhibitor, such as avanafil (Stendra), sildenafil (Revatio, Viagra, and others), tadalafil (Cialis and others), or vardenafil (Levitra, Staxyn), which is a medicine used for erectile dysfunction or pulmonary arterial hypertension (PAH)
  • A benzodiazepine, such as midazolam or triazolam, which is a medicine used for anxiety or seizures
  • Any other medicine for HIV
  • A medicine for hepatitis C
  • An antacid
  • An H2 blocker, such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), or ranitidine (Zantac)
  • A proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex)

Many other medicines may alter the blood levels of Tybost, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Tybost. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Tybost?

If you or someone else has used too much Tybost, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Tybost?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

Missing doses of Tybost can cause it to not work as well over time. So it is important not to miss or skip doses.