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Overview: Obizur is used to treat certain types of bleeding in some people with hemophilia A. It works by replacing a protein called factor VIII, which temporarily helps your blood to clot properly. Some people have an immune system reaction to Obizur that causes it to stop working as well. Talk to your health care provider if you think Obizur is not working or if you have any side effects that bother you.

Uses

What is Obizur used for?

Hemophilia A is a condition that causes your blood to not clot properly. Obizur (antihemophilic factor, recombinant) is commonly used to treat certain types of bleeding in some people with hemophilia A.

Obizur may also be used for other conditions as determined by your health care provider.

How does Obizur work (mechanism of action)?

Hemophilia A is caused when your body does not make enough of a certain protein called factor VIII, which normally helps cause your blood to clot. Obizur works by replacing factor VIII, which temporarily helps your blood to clot properly.

How is Obizur supplied (dosage forms)?

Obizur is available in an injectable form in single-dose vials.

How should I store Obizur?

Obizur is usually given by a health care provider in a hospital or clinic. If you will store Obizur at home, follow the instructions given by your health care provider.

Side Effects

What are the most common side effects of Obizur?

The most common side effect of Obizur is that some people have an immune system reaction to the medicine that causes it to stop working as well. Talk to your health care provider if you think Obizur is not working or if you have any side effects that bother you.

There may be other side effects of Obizur that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Obizur?

While less common, the most serious side effects of Obizur are described below, along with what to do if they happen.

Severe Allergic Reactions. Obizur may cause allergic reactions, which can be serious. Stop using Obizur and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Obizur?

Allergies to Ingredients. People who are allergic to any of the following should not use Obizur.

  • Antihemophilic factor, recombinant
  • Obizur
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Obizur.

Allergy to Hamster Proteins. Do not use Obizur if you are allergic to hamster proteins. Tell your health care provider if you are allergic to hamsters or hamster proteins.

Congenital Hemophilia A With Inhibitors. Some people with hemophilia A have a certain type of the condition called congenital hemophilia A with inhibitors. This means hemophilia is caused by your genes, and your immune system reacts against factor VIII. Do not use Obizur if you have this condition. Ask your health care provider if you have congenital hemophilia with inhibitors.

What should I know about Obizur before using it?

Obizur is usually given by a health care provider in a hospital or clinic. If you have any questions about how to use this medicine, talk to your health care provider.

Your health care provider should monitor your blood work while you are being treated with Obizur. Keep all appointments to have your blood checked.

Some people have an immune system reaction to Obizur that causes it to stop working as well. This is called neutralizing antibodies or inhibitors. Your health care provider should monitor your immune system with blood tests while you are being treated. Talk to your health care provider if you think Obizur is not working.

What should I tell my health care provider before using Obizur?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Obizur is right for you.

In particular, make sure that you discuss any of the following.

Planned Surgery. Tell your health care provider if you have any planned surgeries or procedures.

Pregnancy. It is not known if or how Obizur could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Obizur passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Obizur?

For more information about Obizur, you can call the drugmaker at 877-825-3327.

Interactions

Does Obizur interact with foods or drinks?

There are no known interactions between Obizur and foods or drinks.

It is unknown if drinking alcohol will affect Obizur.

Does Obizur interact with other medicines (drug interactions)?

There are no known interactions between Obizur and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Obizur?

If you or someone else has used too much Obizur, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Obizur?

Obizur is usually given by a health care provider in a hospital. Your health care provider will make sure you are receiving Obizur as scheduled. If you have questions about missed doses, talk with your health care provider.