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Uses

What is Savaysa used for?

Savaysa (edoxaban) is commonly used for the following conditions. 

  • To prevent strokes and blood clots in people who have atrial fibrillation. People who have atrial fibrillation have an abnormal heartbeat that can cause a stroke.
  • To treat blood clots that can form in your veins (deep vein thrombosis or DVT) or lungs (pulmonary embolism)

Savaysa may also be used for other conditions as determined by your healthcare provider.

How does Savaysa work (mechanism of action)?

Savaysa is a blood thinner. It blocks substances in your blood from forming a blood clot.

How is Savaysa supplied (dosage forms)?

Brands and other names

  • Savaysa

Dosage forms and strengths

  • 15 mg, 30 mg, 60 mg oral tablets

How should I store Savaysa?

Savaysa should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store it in a place where children cannot reach it.

Side Effects

What are the most common side effects of Savaysa?

The most common side effects of Savaysa are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

There may be other side effects of Savaysa that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Savaysa?

While less common, the most serious side effects of Savaysa are described below, along with what to do if they happen.

Severe Allergic Reactions. Savaysa may cause allergic reactions, which can be serious. Stop taking Savaysa and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Severe Bleeding. Savaysa can increase your risk of severe bleeding that can lead to death. Some patients with serious bleeding may need a blood transfusion or surgery. Call your healthcare provider or go to the emergency room right away if you have any of the following signs of severe bleeding while taking Savaysa. 

  • Any bleeding that lasts a long time, will not stop, or is very severe
  • Bleeding from the gums
  • Frequent or severe nosebleeds
  • Abnormal vaginal bleeding or very heavy menstrual periods
  • Pink, red, or brown urine (pee)
  • Blood in your stools (this may look red or black and tarry)
  • Vomit with blood that looks like coffee grounds
  • Headaches or feeling dizzy
  • Coughing up blood or blood clots

Warnings & Precautions

Who should not use Savaysa?

Allergies to Ingredients. People who are allergic to any of the following should not take Savaysa.

  • Savaysa
  • Edoxaban
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Savaysa.

Unusual Bleeding. Do not take Savaysa without talking to your healthcare provider if you have any abnormal or unusual bleeding.

Liver Problems. Savaysa should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.

What should I know about Savaysa before using it?

Do not take Savaysa unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Do not share Savaysa with other people, even if they have the same condition as you. It may harm them.

Keep Savaysa out of the reach of children.

Do not stop taking Savaysa without talking to your healthcare provider. Your healthcare provider will decide how long you should take Savaysa for.  Always refill your prescription before you run out of medicine so that you don’t run out or miss any doses. Stopping Savaysa can increase the risk for a blood clot or stroke. 

If you cannot swallow Savaysa tablets whole, reach out to your pharmacist or healthcare provider. They can help you find other ways to take your medicine. 

What should I tell my healthcare provider before using Savaysa?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Savaysa is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Kidney problems
  • Liver Problems
  • Bleeding problems
  • Antiphospholipid syndrome, which is a disorder that causes abnormal clotting
  • Mechanical heart valve
  • Cancer of the stomach or intestine

Planned Procedures. Tell all of your healthcare providers that you or your child are taking Savaysa. Talk to the healthcare provider who prescribed Savaysa to find out whether you should stop taking it before you have any surgery, medical, or dental procedure. 

Other Medicines and Supplements. Savaysa may interact with other medicines and supplements. Before taking Savaysa, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Savaysa could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take Savaysa while you are pregnant or trying to get pregnant.

Breastfeeding. It is not known if Savaysa passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop Savaysa.

How can I get more information about Savaysa?

For more information about Savaysa, you can visit the manufacturer’s website at savaysa.com or call them at 877-437-7763.

Interactions

Does Savaysa interact with foods or drinks?

There are no known interactions between Savaysa and foods or drinks.

It is unknown if drinking alcohol will affect Savaysa, but both Savaysa and alcohol can increase your risk of bleeding. It is best to limit the amount of alcohol you drink.

Does Savaysa interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Savaysa. 

  • A selective serotonin reuptake inhibitor (SSRI), which is a medicine commonly used for anxiety and depression
  • A serotonin norepinephrine reuptake inhibitor (SNRI), which is a medicine commonly used for anxiety and depression
  • A nonsteroidal anti-inflammatory drug (NSAID), such as ibuprofen, naproxen, and others, which are contained in many prescription and OTC products for pain, swelling, and fever
  • Any other blood thinner, which is a medicine used to treat or prevent blood clots such as warfarin (Coumadin or Jantoven) or medicines that contain heparin
  • Aspirin, which is in many prescription and OTC products, including those for pain, swelling, and fever
  • Rifampin, which is a medicine commonly used to treat an infection called tuberculosis

Some other medicines may alter the blood levels of Savaysa. Tell your healthcare provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Savaysa. Always check with your healthcare provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Savaysa?

If you or someone else has used too much Savaysa, get medical help right away, go to the nearest emergency room, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Savaysa?

If you miss a dose of Savaysa, take it as soon as possible on the same day. Take your next dose as usual on the following day. Do not take more than one dose at a time or double-up on doses to make up for a missed dose.