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Overview: Mytesi is used to relieve diarrhea that is not caused by an infection in people who are on medicines for HIV or AIDS. This medicine helps reduce water loss and diarrhea. Common side effects include an infection in the nose or throat, bronchitis, and cough.

Uses

What is Mytesi used for?

Mytesi (crofelemer) is commonly used to relieve diarrhea that is not caused by an infection in people who are on medicines for HIV or AIDS.

Mytesi may also be used for other conditions as determined by your health care provider.

How does Mytesi work (mechanism of action)?

Mytesi works by blocking certain channels in the intestines that control the release of chloride and water. By doing this, it helps reduce water loss and diarrhea, bringing the balance of fluids in the digestive system back to normal.

How is Mytesi supplied (dosage forms)?

Mytesi is available as 125 mg delayed-release oral tablets.

How should I store Mytesi?

Mytesi should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Mytesi?

The most common side effects of Mytesi are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Infection in the nose or throat, sore throat, or common cold symptoms
  • Bronchitis
  • Cough
  • Gas
  • Increased bilirubin

There may be other side effects of Mytesi that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Mytesi?

While less common, the most serious side effects of Mytesi are described below, along with what to do if they happen.

Severe Allergic Reactions. Mytesi may cause allergic reactions, which can be serious. Stop taking Mytesi and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Mytesi?

Allergies to Ingredients. People who are allergic to any of the following should not take Mytesi.

  • Crofelemer
  • Mytesi
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Mytesi.

What should I know about Mytesi before using it?

Do not take Mytesi unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Mytesi with other people, even if they have the same condition as you. It may harm them.

Keep Mytesi out of the reach of children.

Your health care provider may test your stool (poop) before starting Mytesi to rule out any infections that may be causing your diarrhea. Talk to your health care provider if you have any concerns.

Swallow Mytesi tablets whole. Do not crush or chew the tablets.

What should I tell my health care provider before using Mytesi?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Mytesi is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. Mytesi is not well absorbed by the body and is not expected to reach the baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Mytesi passes into breast milk. Do not take Mytesi while you are breastfeeding. There may be risks with breastfeeding while taking Mytesi and having HIV. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Mytesi?

For more information about Mytesi, you can visit the drugmaker’s website at mytesi.com or call them at 844-722-8256.

Interactions

Does Mytesi interact with foods or drinks?

There are no known interactions between Mytesi and foods or drinks.

It is unknown if drinking alcohol will affect Mytesi.

Does Mytesi interact with other medicines (drug interactions)?

There are no known interactions between Mytesi and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Mytesi?

If you or someone else has used too much Mytesi, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Mytesi?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.