Dupixent (dupilumab) - Uses, Side Effects, and More

What are the most common side effects of Dupixent?

The most common side effects of Dupixent are listed below. These side effects may vary depending on the condition that is being treated. Tell your healthcare provider if you have any of these side effects that bother you.

• Pain, itching, swelling, or redness near the injection site, which usually goes away
• Infection in the nose or throat, sore throat, or common cold symptoms
• Eye problems, such as redness, swelling, and itching of the eyes, sometimes with blurry vision, or dry eyes (see below)
• Cold sores in the mouth or on the lips
• High levels of certain type of white blood cell, called eosinophils
• Infections, including kidney or bladder infections
• Back, joint, or muscle pain
• Runny or stuffy nose
• Dizziness
• Diarrhea
• Throat or stomach pain
• Trouble sleeping
• Toothache
• Headache

There may be other side effects of Dupixent that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Dupixent?

While less common, the most serious side effects of Dupixent are described below, along with what to do if they happen.

Severe Allergic Reactions. Dupixent can cause allergic reactions, including skin reactions, which can be serious. Stop using Dupixent and get help right away if you have any of the following symptoms of a serious allergic reaction.

• Breathing problems or wheezing
• Racing heart
• Fever or general ill feeling
• Swollen lymph nodes
• Swelling of the face, lips, mouth, tongue, or throat
• Trouble swallowing or throat tightness
• Itching, skin rash that looks like a bullseye, bumps on the skin called hives, or pus-filled spots on the skin
• Nausea or vomiting
• Dizziness, feeling lightheaded, or fainting
• Stomach cramps
• Joint pain

Eye Problems. Tell your healthcare provider if you have any new eye problems or if your eye problems get worse while using Dupixent. Examples of eye problems include eye pain, vision changes, or blurry vision.

High eosinophil levels. Eosinophils are a type of white blood cell that helps to fight disease. In some people, Dupixent can cause eosinophil levels to rise. Small increases in eosinophil levels do not usually cause any symptoms. However, large increases in eosinophil levels can cause serious adverse effects, including swelling (inflammation) of the lungs or blood vessels. Call your healthcare provider right away if you have any of the following symptoms of these conditions.

• Chest pain
• Cough (worse than normal)
• Fever
• Numbness or feeling pins and needles in the arms or legs
• Skin rash
• Shortness of breath (worse than normal)

Joint Pain. People using Dupixent may have joint pain or aches. In some cases, these joint problems can make it hard to walk or move. Some people had to go to the hospital for these problems. Tell your healthcare provider if you have any new joint pain or problems, or if these get worse while using Dupixent.