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Overview: Mavyret is used to treat chronic hepatitis C virus (HCV) infection. It works by preventing the hepatitis C virus from making copies of itself. Common side effects include headache and tiredness. Tell your health care provider about any medical conditions you have or have had in the past, including any other liver problems. Mavyret comes as either a tablet or pellets that you take by mouth.

Uses

What is Mavyret used for?

Mavyret (glecaprevir/pibrentasvir) is commonly used to treat certain types of chronic hepatitis C virus (HCV) infection.

Mavyret may also be used for other conditions as determined by your health care provider.

How does Mavyret work (mechanism of action)?

Mavyret contains two medicines: glecaprevir and pibrentasvir. They work together to prevent the hepatitis C virus from making copies of itself. Mavyret reduces the amount of virus in your body, which can help your body get rid of the virus.

How is Mavyret supplied (dosage forms)?

Brands and other names

  • Mavyret

Dosage forms and strengths

  • 100 mg/40 mg oral tablets
  • 50 mg/20 mg oral pellets

How should I store Mavyret?

Oral Tablet. Mavyret oral tablet should be stored in its original container at a temperature below 86 F (30 C). 

Oral Pellet. Mavyret oral pellets should be stored at a temperature below 86 F (30 C). Do not open each packet of pellets until you are ready to take it.

Side Effects

What are the most common side effects of Mavyret?

The most common side effects of Mavyret are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Headache
  • Tiredness

There may be other side effects of Mavyret that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Mavyret?

While less common, the most serious side effects of Mavyret are described below, along with what to do if they happen.

Hepatitis B Virus Reactivation. If you have the hepatitis B virus in your body or have had hepatitis B in the past, Mavyret could make the virus active again. This could lead to serious liver problems or death. Keep all appointments for blood tests before starting Mavyret and during treatment. Call your health care provider right away if you have any of the following symptoms of hepatitis.

  • Unusual tiredness
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
  • Nausea, vomiting, or loss of appetite
  • Dark-colored pee
  • Fever or chills
  • Pain in your side
  • Clay-colored stool (poop)

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking Mavyret. The risk may be higher in people who have severe liver problems before starting Mavyret. Call your health care provider right away if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored pee
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Severe Allergic Reactions. Mavyret may cause allergic reactions, which can be serious. Stop taking Mavyret and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Mavyret?

Allergies to Ingredients. People who are allergic to any of the following should not take Mavyret.

  • Glecaprevir
  • Mavyret
  • Pibrentasvir
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Mavyret.

Liver Problems. Mavyret should not be used if your liver is not working as well as it should be or if you have had certain liver problems in the past. If there is a concern about the health of your liver, your health care provider may do tests to determine if it is working well enough to take this medicine.

Drug Interactions. Mavyret should not be taken while you are using certain other medicines. Before taking Mavyret, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

What should I know about Mavyret before using it?

Do not take Mavyret unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Mavyret with other people, even if they have the same condition as you. It may harm them.

Take each dose of Mavyret with food. 

Mavyret comes as either tablets or pellets that are swallowed. Read and follow the instructions for the product you have and make sure you understand how to use it properly. If you have any questions, talk to your health care provider.

If you are taking the oral pellets, sprinkle them onto a small amount of soft food with a low amount of water that will stick to a spoon. Soft foods that may be used include peanut butter, Greek yogurt, chocolate hazelnut spread, or a thick jam. Do not use liquids or foods that could easily drip or slide off the spoon because this could make the medicine not work as well. After the pellets are sprinkled onto food, the mixture should be swallowed within 15 minutes. Do not chew or crush the oral pellets. 

Keep Mavyret out of the reach of children.

Make sure that you get refills before you run out of Mavyret. Do not stop taking it without talking to your health care provider first. 

What should I tell my health care provider before using Mavyret?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Mavyret is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Past or current hepatitis B infection
  • Liver problems other than hepatitis C infection
  • Liver or kidney transplant
  • HIV

Pregnancy. It is not known if or how Mavyret could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Mavyret passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Mavyret while breastfeeding.

How can I get more information about Mavyret?

For more information about Mavyret, you can visit the drugmaker’s website at www.mavyret.com or call them at 877-628-9738.

Interactions

Does Mavyret interact with foods or drinks?

There are no known interactions between Mavyret and foods or drinks. 

If you are taking Mavyret oral pellets, they should be sprinkled on soft foods with a low water content. See the Warnings & Precautions section for more information.

It is unknown if drinking alcohol will affect Mavyret. 

Does Mavyret interact with other medicines (drug interactions)?

Mavyret interacts with many other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss with your health care provider if you are using any of the following before taking Mavyret. 

  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • A medicine for HIV or AIDS or any other medicine for hepatitis C
  • A medicine for diabetes
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
  • Carbamazepine (Carbatrol, Tegretol, and others), which is a medicine commonly used to treat seizures or nerve pain
  • Phenytoin (Dilantin, Phenytek, and others), which is a medicine to control seizures
  • St. John’s wort, which is a supplement that may be used for depression
  • A statin, such as atorvastatin (Lipitor and others) or rosuvastatin (Crestor), which is a medicine to lower cholesterol
  • Estrogen, which is found in certain birth control pills, patches, creams, rings, or vaginal suppositories
  • Cyclosporine (Gengraf, Neoral, Sandimmune, and others), which is a medicine that suppresses your immune system
  • A blood thinner, which is a medicine used to treat or prevent blood clots

Many other medicines may alter the blood levels of Mavyret, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Mavyret. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Mavyret?

If you or someone else has used too much Mavyret, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Mavyret?

If you miss a dose and it is less than 18 hours from the time you usually take it, take it as soon as you remember. Then take your next dose at your regular time. If it is more than 18 hours from the time you usually take it, skip the missed dose and only take the next dose as usual with food. Do not take double or extra doses. 

Missing doses of Mavyret can cause it to not work as well over time. So it is important not to miss or skip doses.