Overview: Yupelri (revefenacin) is used to treat a long-term breathing problem called chronic obstructive pulmonary disease (COPD). It helps relax the muscles around your airways, making it easier to breathe. Common side effects include cough, headache, and infection in the nose or throat, sore throat, or common cold symptoms. Tell your healthcare provider right away if your COPD seems to be getting worse instead of better, or if you have trouble emptying your bladder.
Uses
What is Yupelri used for?
Yupelri (revefenacin) is commonly used to treat chronic obstructive pulmonary disease (COPD). COPD is a long-term lung problem that causes you to have trouble breathing and gradually worsens over time.
Yupelri may also be used for other conditions as determined by your healthcare provider.
How does Yupelri work (mechanism of action)?
Yupelri contains a medicine called revefenacin that helps relax the muscles around the airways, making it easier for you to breathe. Once the muscles can relax, air can flow more easily throughout the lungs. Revefenacin is long-acting, which means the medicine continues to work over a long period of time.
How is Yupelri supplied (dosage forms)?
Brands and other names
- Yupelri
Dosage forms and strengths
- 175 mcg/3 mL inhalation solution
How should I store Yupelri?
Yupelri should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Keep Yupelri in its original foil packaging to protect from sunlight.
Once the vial has been opened, use it right away and throw out any unused solution. Throw out any unopened vials after the expiration date has passed.
Side Effects
What are the most common side effects of Yupelri?
The most common side effects of Yupelri are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Cough
- Infection in the nose or throat, sore throat, or common cold symptoms
- Headache
- Back pain
There may be other side effects of Yupelri that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Yupelri?
While less common, the most serious side effects of Yupelri are described below, along with what to do if they happen.
Severe Allergic Reactions. Yupelri may cause allergic reactions, which can be serious. Stop using Yupelri and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Breathing Problems. Yupelri may cause the muscles around your airways to tighten (bronchospasm) right after you use it, instead of relaxing, which can be serious. Stop using Yupelri and contact your healthcare provider right away if you have trouble breathing.
Glaucoma. Using Yupelri may increase pressure inside the eye and cause or worsen narrow-angle glaucoma, which can lead to blindness. Tell your healthcare provider right away if you have any of the following symptoms of glaucoma.
- Blurry vision or loss of vision
- Eye pain or redness
- Severe headache or vomiting
- Seeing bright, colorful circles around lights (vision halos)
Inability to Empty Bladder (Urinary Retention). Yupelri might make it harder to empty your bladder, especially if you already have a blockage or trouble peeing. Stop using Yupelri and call your healthcare provider right away if you have a hard time peeing or have a weak stream, if peeing is painful, or if you are peeing frequently.
Warnings & Precautions
Who should not use Yupelri?
Allergies to Ingredients. People who are allergic to any of the following should not use Yupelri.
- Yupelri
- Revefenacin
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all the ingredients in Yupelri.
What should I know about Yupelri before using it?
Do not use Yupelri unless it has been prescribed to you by a healthcare provider. Use it as prescribed.
Your pharmacist or other healthcare provider will show you how to correctly use and clean Yupelri. Follow the “Instructions for Use” that comes with Yupelri when using it for the first time or when you have not used it for a while. If you have any questions about how to use it, talk to your pharmacist or other healthcare provider.
Yupelri is not a rescue medicine. It should not be used to treat sudden breathing problems. It is used daily as a maintenance medicine. Yupelri should not be used for COPD that is getting worse quickly over time. If you are using your rescue inhaler (such as an albuterol inhaler) more often than usual, contact your healthcare provider to discuss your COPD medicines.
Do not share Yupelri with other people, even if they have the same condition as you. It may harm them.
Keep Yupelri out of the reach of children.
What should I tell my healthcare provider before using Yupelri?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Yupelri is right for you.
In particular, make sure that you discuss any of the following.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Eye problems, such as glaucoma
- Prostate or bladder problems or trouble peeing
- Liver problems
Other Medicines and Supplements. Yupelri may interact with other medicines and supplements. Before using Yupelri, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Pregnancy. It is not known if or how Yupelri could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.
Breastfeeding. It is not known if Yupelri passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Yupelri while breastfeeding.
How can I get more information about Yupelri?
For more information about Yupelri, you can visit the manufacturer’s website at www.yupelri.com or call them at 800-796-9526.
Interactions
Does Yupelri interact with foods or drinks?
There are no known interactions between Yupelri and foods or drinks.
It is unknown if drinking alcohol will affect Yupelri.
Does Yupelri interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or OTC medicines, vitamins/minerals, herbal products, and other supplements you are taking.
In particular, make sure that you discuss if you are using any of the following before using Yupelri.
- An anticholinergic medicine, which includes antihistamines and medicines commonly used for overactive bladder, Parkinson’s disease, or stomach problems
- Any other long-acting muscarinic antagonist (LAMA) medicine like Yupelri, such as aclidinium (Tudorza Pressair), tiotropium (Spiriva), or umeclidinium (Incruse)
- Cyclosporine (Gengraf, Neoral, Sandimmune, and others), which is a medicine to suppress your immune system
- Rifampin, which is a medicine commonly used to treat an infection called tuberculosis
Some other medicines may alter the blood levels of Yupelri. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Yupelri. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Yupelri?
If you or someone else has used too much Yupelri, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Yupelri?
If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses.
Are you currently using Yupelri (revefenacin)?
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