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Overview: Jeuveau is commonly used to temporarily improve frown lines between your eyebrows. The most common side effects are headache, drooping eyelids, and common cold symptoms. Serious side effects are less common but can include dry eyes, problems breathing, speaking or swallowing, and botulism. Jeuveau is an injection given to you by a healthcare provider.

Uses

What is Jeuveau used for?

Jeuveau (prabotulinumtoxinA-xvfs) is commonly used to temporarily improve the look of moderate to severe frown lines between the eyebrows.

Jeuveau may also be used for other conditions as determined by your healthcare provider.

How does Jeuveau work (mechanism of action)?

Jeuveau works beneath your skin by blocking certain nerve signals and reducing activity in the muscles between your eyebrows. This muscle activity can lead to the appearance of wrinkles and lines, such as frown lines. By reducing the muscle activity between your eyebrows, Jeuveau temporarily makes lines on your face look better. 

How is Jeuveau supplied (dosage forms)?

Brands and other names

  • Jeuveau

Jeuveau is available as an injection that is given by a healthcare provider.

How should I store Jeuveau?

Jeuveau is usually given by a healthcare provider in a hospital or clinic. If you will store Jeuveau at home, follow the instructions given by your healthcare provider.

Side Effects

What are the most common side effects of Jeuveau?

The most common side effects of Jeuveau are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Headache
  • Drooping eyelids
  • Infection in the nose or throat, sore throat, or common cold symptoms
  • Increased white blood cell levels

There may be other side effects of Jeuveau that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Jeuveau?

While less common, the most serious side effects of Jeuveau are described below, along with what to do if they happen.

Spread of Toxin Effects. The medicine in Jeuveau may affect areas of your body away from the injection site. This may cause symptoms of a serious condition called botulism. Symptoms of botulism can start within hours, days, or weeks after your dose. Contact your healthcare provider right away if you have any of the following symptoms of botulism.

  • Loss of strength or muscle weakness all over the body
  • Double vision, blurred vision, and drooping eyelids
  • Losing your voice, changes in your voice, hoarseness, or trouble saying words clearly (dysarthria)
  • Loss of bladder control
  • Trouble breathing or swallowing

Severe Allergic Reactions. Jeuveau may cause allergic reactions, which can be serious. Stop using Jeuveau and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Breathing, Swallowing, or Speaking Problems. Jeuveau may cause problems with breathing, swallowing or speaking. This can be serious or life-threatening. This is caused if the muscles you use to breathe and swallow become weak after the injection. It can happen hours, days, or weeks after your dose. Swallowing difficulties can last for several months. People who have trouble swallowing may need a feeding tube to get food and water. If swallowing issues are severe, food or liquids could get into your lungs. Get emergency medical help right away if you have trouble breathing, swallowing, or speaking.

Heart Effects. Jeuveau may increase your risk of certain effects on the heart, such as causing an abnormal heart rhythm (arrhythmia) or a heart attack, which could lead to death. Get emergency help if you have chest pain or pressure, trouble breathing, or if you have a change in your heart rate or rhythm, such as a fast, slow, pounding, or skipping heartbeat.

Eye Dryness. Jeuveau may cause dry eyes if it is injected near your eyes. Tell your healthcare provider if you have any of the following symptoms of eye dryness.

  • Changes in your vision
  • Eye pain or irritation
  • Eyes sensitive to light

Warnings & Precautions

Who should not use Jeuveau?

Allergies to Ingredients. People who are allergic to any of the following should not use Jeuveau.

  • PrabotulinumtoxinA
  • Jeuveau
  • Any other medicine known as a botulinum toxin product
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Jeuveau.

 

Skin Infection at the Injection Site. Jeuveau should not be injected into skin that is infected. Tell your healthcare provider if you have any symptoms of skin infection, such as redness, pain, swelling, warm skin, or blisters.

 

What should I know about Jeuveau before using it?

Do not use Jeuveau unless it has been prescribed to you by a healthcare provider. Your healthcare provider will store and give you the medicine. 

Jeuveau may cause loss of strength, muscle weakness, vision problems, or drooping eyelids within hours, days, or weeks after an injection. If any of these happen to you, do not drive or do other activities that require alertness or coordination.

What should I tell my healthcare provider before using Jeuveau?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Jeuveau is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Muscle or nerve disorders, such as amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome
  • Breathing problems, such as asthma or emphysema
  • Swallowing problems
  • Plans to have surgery
  • Past surgery on your face
  • Bleeding problems
  • Heart problems, including heart disease
  • Muscle weakness in or near the planned injection site
  • Drooping eyelids
  • Changes in the way your face normally looks
  • Dry eyes after receiving any other botulinum product

Other Medicines and Supplements. Jeuveau may interact with other medicines and supplements. Before using Jeuveau, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Jeuveau could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Jeuveau passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Jeuveau while breastfeeding.

How can I get more information about Jeuveau?

For more information about Jeuveau, you can visit the manufacturer’s website at www.jeuveau.evolus.com or call them at 858-293-1152.

Interactions

Does Jeuveau interact with foods or drinks?

There are no known interactions between Jeuveau and foods or drinks.

It is unknown if drinking alcohol will affect Jeuveau. If you have vision problems, such as blurred vision, from Jeuveau alcohol may worsen this effect.

Does Jeuveau interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using Jeuveau.

  • A botulinum toxin product, such as rimabotulinumtoxinB (Myobloc), onabotulinumtoxinA (Botox, Botox Cosmetic), abobotulinumtoxinA (Dysport), daxibotulinumtoxinA (Daxxify), or incobotulinumtoxinA (Xeomin), which is a medicine commonly used to reduce wrinkles or spasms.
  • An aminoglycoside antibiotic, such as amikacin or gentamicin, which is given by injection to treat infections
  • An anticholinergic medicine, which includes antihistamines and medicines commonly used for overactive bladder, Parkinson’s disease, or stomach problems
  • A muscle relaxant, such as carisoprodol (Soma), cyclobenzaprine, or tizanidine (Zanaflex)
  • A sleep medicine, such as temazepam (Restoril), zolpidem (Ambien and others), or eszopiclone (Lunesta)
  • Aspirin, which is in many prescription and OTC products including those for pain, swelling, and fever
  • An antiplatelet medicine, such as clopidogrel (Plavix), ticagrelor (Brilinta), aspirin/dipyridamole, or cilostazol, which is a medicine used to prevent blood clots
  • A blood thinner, which is a medicine used to treat or prevent blood clots

This may not be a complete list of medicines that can interact with Jeuveau. Always check with your healthcare provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Jeuveau?

If you or someone else has used too much Jeuveau, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Jeuveau?

Jeuveau is usually given by a healthcare provider in a clinic. Your healthcare provider will make sure you are receiving Jeuveau as scheduled.

If you miss an appointment to get your Jeuveau dose, call to make another appointment as soon as possible.