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Overview: Beovu is used to treat certain eye conditions that affect a part of your eye called the macula. It works by preventing these abnormal blood vessels from forming. Common side effects include blurred vision, eye bleeding, and eye pain. Contact your health care provider right away if you have vision problems or eye pain.

Uses

What is Beovu used for?

Beovu (brolucizumab-dbll) is commonly used to treat the following conditions that affect a certain part of your eye called the macula.

Beovu may also be used for other conditions as determined by your health care provider.

How does Beovu work (mechanism of action)?

Vascular endothelial growth factor (VEGF) is a natural protein that helps your body form new blood vessels. If your body makes too much of a certain form of VEGF, it can lead to leaky or damaged blood vessels in a part of your eye called the macula, which can cause vision problems. Beovu works by blocking a certain form of VEGF, helping prevent these abnormal blood vessels from forming. This helps protect your vision.

How is Beovu supplied (dosage forms)?

Brands and other names

  • Beovu

Dosage forms and strengths

Beovu is available in an injectable form that is given by a health care provider.

How should I store Beovu?

Beovu is usually given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Beovu?

The most common side effects of Beovu are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Blurred vision
  • Shapes or spots in your vision
  • Cataracts
  • Eye bleeding
  • Eye pain

There may be other side effects of Beovu that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Beovu?

While less common, the most serious side effects of Beovu are described below, along with what to do if they happen.

Severe Allergic Reactions. Beovu may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Eye Infection. Beovu may cause a serious eye infection called endophthalmitis. It can cause you to lose your vision. Call your health care provider right away if you have any of the following symptoms.

  • Eye pain
  • Eye redness
  • Eye sensitivity to bright light
  • White or yellow discharge from your eyes
  • Swollen or puffy eyes or eyelids
  • Blurred vision or trouble seeing

Retinal Detachment. Beovu may cause retinal detachment. The retina is a layer of tissue in the back of your eye. Retinal detachment occurs when the retina peels back, or detaches, from the tissue around it. Tell your health care provider right away if you have any of the following symptoms.

  • Flashes of light
  • Floaters, spots, or threads in your vision
  • Darkness or a “curtain” over your vision, including the middle or the sides

Eye Inflammation. Beovu may cause a condition called retinal vasculitis, which is inflammation (swelling) that affects the blood vessels in the retina of your eye. Tell your health care provider right away if you have any of the following symptoms of retinal vasculitis.

  • Vision problems
  • Blurred vision
  • Floaters in your vision
  • Blind spots or partial loss of vision

Blocked Eye Blood Vessels. Beovu may cause a condition called retinal vascular occlusion, a blockage in the blood vessels that supply the retina with blood. Tell your health care provider right away if you have any of the following symptoms.

  • Vision problems
  • Blurred vision
  • Partial loss of vision

Increased Eye Pressure. Beovu may increase the pressure in your eye (intraocular pressure) within 30 minutes of your injection. Your health care provider will monitor your eye pressure.

Blood Clots. Beovu may cause a blood clot in your arteries or veins and could cause a stroke, heart attack, or venous thromboembolism, including a blood clot in the lungs (pulmonary embolism) or deep vein thrombosis (DVT). Get emergency help if you have any of the following signs of blood clots. 

  • Chest pain or pressure
  • Fast or abnormal heartbeat
  • Trouble breathing
  • Pain in your back, jaw, throat, or arm
  • Sweating, upset stomach, vomiting, or dizziness
  • Sudden weakness on one side of your body
  • Sudden and severe headache
  • Slurred speech or trouble understanding speech
  • Pain, swelling, or tenderness in your arm or leg
  • Vision loss
  • Bulging eyes
  • Double vision

Warnings & Precautions

Who should not use Beovu?

Allergies to Ingredients. People who are allergic to any of the following should not use Beovu.

  • Beovu
  • Brolucizumab
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Beovu.

Eye Infection. Beovu should not be used if you have an infection in your eye or around your eye. Talk to your health care provider if you have an eye infection.

Eye Inflammation. Beovu should not be used if you have certain types of eye inflammation. Talk to your health care provider if you have eye inflammation.

What should I know about Beovu before using it?

Do not use Beovu unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Beovu with other people, even if they have the same condition as you. It may harm them.

Beovu is usually given by a health care provider in a hospital or clinic.

Treatment with Beovu may temporarily affect your vision after you receive your injection. Do not plan to drive or do other activities that require clear vision right after your treatment.

What should I tell my health care provider before using Beovu?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Beovu is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Beovu could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should take Beovu while you are pregnant or trying to get pregnant. If you can become pregnant, use effective birth control during treatment with Beovu and for at least one month after.

Breastfeeding. Breastfeeding is not recommended during treatment with Beovu, and for at least one month after your last dose. It is not known if Beovu passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Beovu while breastfeeding.

How can I get more information about Beovu?

For more information about Beovu, you can call the drugmaker at 888-669-6682.

Interactions

Does Beovu interact with foods or drinks?

There are no known interactions between Beovu and foods or drinks.

It is unknown if drinking alcohol will affect Beovu.

Does Beovu interact with other medicines (drug interactions)?

There are no known interactions between Beovu and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Beovu?

If you or someone else has used too much Beovu, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Beovu?

Beovu is usually given by a health care provider in a hospital. Your health care provider will make sure you are receiving the medicine as scheduled.

If you miss an appointment to get your Beovu dose, call to make another appointment as soon as possible.