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Dojolvi is used to treat certain metabolic disorders where the body cannot break down long-chain fatty acids. It works by providing a type of fat that the body can use for energy. Common side effects include stomach discomfort, such as belly pain and diarrhea. Dojolvi comes in a liquid that is taken by mouth or through a feeding tube. It should always be mixed with food or liquid as directed by your health care provider.

Uses

What is Dojolvi used for?

Dojolvi (triheptanoin) is commonly used to treat long-chain fatty acid oxidation disorders (LC-FAOD). These are a rare group of inherited metabolic disorders where your body cannot break down certain fatty acids for energy. 

Dojolvi may also be used for other conditions as determined by your health care provider.

How does Dojolvi work (mechanism of action)?

Most of the fat found in food is made up of long-chain fatty acids. People with LC-FAOD cannot get energy from these fats because their bodies cannot break these fats down. Dojolvi provides a source of calories for people with LC-FAOD. It contains a special type of fat, called a medium-chain triglyceride, that people with LC-FAOD can use for energy. 

How is Dojolvi supplied (dosage forms)?

Brands and other names

  • Dojolvi

Dosage forms and strengths

  • 100% w/w oral liquid

How should I store Dojolvi?

Dojolvi should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store it in a cool, dry place. Do not freeze it. Keep Dojolvi in the bottle it comes in.

Side Effects

What are the most common side effects of Dojolvi?

The most common side effects of Dojolvi are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Stomach pain
  • Diarrhea
  • Vomiting
  • Nausea

There may be other side effects of Dojolvi that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Dojolvi?

While less common, the most serious side effects of Dojolvi are described below, along with what to do if they happen.

Severe Allergic Reactions. Dojolvi may cause allergic reactions, which can be serious. Stop taking Dojolvi and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not take Dojolvi?

Allergies to Ingredients. People who are allergic to any of the following should not take Dojolvi.

  • Dojolvi
  • Triheptanoin
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Dojolvi.

What should I know about Dojolvi before taking it?

Do not take Dojolvi unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Dojolvi with other people, even if they have the same condition as you. It may harm them.

Keep Dojolvi out of the reach of children.

After the bottle of Dojolvi is opened, it should be used within nine months, unless the expiration date comes first.

Make sure that you or a caregiver understands how to properly prepare, take, and throw away Dojolvi. Read and follow the instructions that come with your medicine. If you have any questions, talk to your health care provider. 

Dojolvi can be taken by mouth or through a feeding tube. If you take Dojolvi by mouth, mix it well with a soft food or drink, such as fat-free yogurt. If you take Dojolvi through a feeding tube, mix it well with formula or medical food. Always take Dojolvi as a mixture. Taking it alone may cause stomach upset. 

If you take Dojolvi through a feeding tube, the medicine can damage the tube. Do not use feeding tubes made of polyvinyl chloride (PVC) plastic with Dojolvi. Check your feeding tube regularly while taking Dojolvi to make sure it is working correctly and is not damaged.

Dojolvi can damage certain types of materials. Do not pour it down the sink. Do not put Dojolvi into containers, oral syringes, tubes, or measuring cups made of PVC or polystyrene, which is a type of plastic or foam. Only use containers made of glass, stainless steel, or other safe materials as directed by your health care provider. 

Follow any instructions from your health care provider about your diet. Tell your health care provider if you have stomach side effects that bother you, such as stomach pain, diarrhea, or nausea. Your health care provider may want to adjust your dose if you have side effects.

What should I tell my health care provider before taking Dojolvi?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Dojolvi is right for you.

In particular, make sure that you discuss any of the following.

Other Medicines and Supplements. Dojolvi may interact with other medicines and supplements. Before taking Dojolvi, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Low Pancreas Enzymes. Enzymes made by your pancreas help your body break down fats. These enzymes also help break down Dojolvi. Without enough of these enzymes, Dojolvi may not work well for you. Tell your health care provider if you have any problems affecting your pancreas or if you have low levels of enzymes made by your pancreas, also known as pancreatic insufficiency. 

Pregnancy. It is not known if or how Dojolvi could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. If you become pregnant while taking Dojolvi, tell your health care provider. You can also contact the drugmaker, Ultragenyx Pharmaceutical, at 888-756-8657. The drugmaker is collecting safety information about the use of Dojolvi during pregnancy.

Breastfeeding. It is not known if Dojolvi passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should take Dojolvi while breastfeeding.

How can I get more information about Dojolvi?

For more information about Dojolvi, you can visit the drugmaker’s website at www.dojolvi.com or call them at 888-756-8657.

Interactions

Does Dojolvi interact with foods or drinks?

Take Dojolvi with meals or snacks as directed by your health care provider. Dojolvi should be mixed well with certain soft foods or liquids. Some examples are fat-free yogurt or formula. For a complete list of options, see the instructions that come with your medicine or ask your health care provider.

It is unknown if drinking alcohol will affect Dojolvi.

Does Dojolvi interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Dojolvi.

  • A pancreatic lipase inhibitor, such as orlistat (Alli, Xenical), which is a medicine used to help people lose weight
  • Any other medium-chain triglyceride (MCT) product, such as MCT oil

This may not be a complete list of medicines that can interact with Dojolvi. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally take too much Dojolvi?

If you or someone else has taken too much Dojolvi, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Dojolvi?

If you miss a dose, take it as soon as possible, but only if you can take that day’s remaining doses at least 3-4 hours apart. Skip the missed dose if it will not be possible to fit all of your prescribed doses in a day. Do not take double or extra doses.