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Overview: Tecartus is used to treat certain types of blood cancer. It is made using cells from your body and works by enhancing your immune system to find and attack cancer cells. Common side effects include fever, tiredness, low blood pressure, and nausea. Tell your health care provider or get help right away if you have a high fever, chills, shaking, fast heartbeat, trouble breathing, confusion, or trouble moving or speaking.

Uses

What is Tecartus used for?

Tecartus (brexucabtagene autoleucel) is commonly used for the following types of blood cancers in certain people. It is typically used after other treatments have not worked or stopped helping.

Tecartus may also be used for other conditions as determined by your health care provider.

How does Tecartus work (mechanism of action)?

Tecartus is a chimeric antigen receptor (CAR) T-cell therapy. It is a type of personalized medicine where white blood cells, called T cells, are taken from your body and altered in a lab. This makes the cells grow special proteins on them called CARs, which can enhance their ability to find and attack cancer cells. The new CAR T-cells are then put back into your body to treat your cancer.

How is Tecartus supplied (dosage forms)?

Brands and other names

  • Tecartus

Dosage forms and strengths

Tecartus is available in an injectable form that is given by a health care provider.

How should I store Tecartus?

Tecartus is given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Tecartus?

The most common side effects of Tecartus are listed below. These side effects may vary depending on the condition that is being treated. Tell your health care provider if you have any of these side effects that bother you.

  • Fever and chills
  • Cytokine release syndrome (see Overactive Immune Response below)
  • Low blood pressure, dizziness, tiredness
  • Encephalopathy (see Brain Problems below)
  • Fast or irregular heartbeat
  • Infections (see below)
  • Cough
  • Shaking (tremor)
  • Muscle and bone pain
  • Headache
  • Nausea, vomiting, constipation, diarrhea
  • Fluid retention
  • Trouble with movements or speaking
  • Loss of appetite
  • Shortness of breath
  • Rash
  • Trouble sleeping

There may be other side effects of Tecartus that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Tecartus?

While less common, the most serious side effects of Tecartus are described below, along with what to do if they happen.

Severe Allergic Reactions. Tecartus may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Overactive Immune Response. Tecartus can cause dangerous and life-threatening conditions called cytokine release syndrome (CRS) and hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome (MAS). Both occur when your immune system responds too much to medicines, cancer, or infection. Get emergency help if you have any of the following symptoms even several weeks after you use Tecartus.

  • Fever or chills
  • Fast or racing heart
  • Dizziness or feeling lightheaded
  • Bleeding
  • Trouble breathing
  • Reduced need to pee
  • Swelling in your feet, ankles, or legs
  • Weakness or unusual tiredness

Nervous System Problems. Tecartus can cause brain or nerve problems, including a condition called immune effector cell-associated neurotoxicity syndrome (ICANS). Get emergency help if you have any of the following symptoms.

  • Confusion
  • Seizures
  • Balance problems
  • Trouble moving or talking 
  • Tremor

Infections. Tecartus can increase your risk of infections, including serious infections. Call your health care provider right away if you have an infection or any of the following symptoms.

  • Fever of 100.4 F (38 C) or higher
  • Burning or stinging when you pee
  • Cough or coughing up blood 
  • Chills, sweating, or muscle aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Weight loss

Reactivated Infections. Some types of microbes that cause infections (such as bacteria or viruses) can remain in the body after you recover from that infection. When a microbe stays in the body but does not cause an infection, it is called a “latent” microbe. Tecartus may increase your risk of a latent microbe becoming active again, causing an infection. Before you start treatment with Tecartus, tell your health care provider if you have hepatitis B, hepatitis C, or any other serious infections.

Blood Disorders. Tecartus can cause blood disorders, such as low red blood cells (anemia), low platelet levels (thrombocytopenia), and low neutrophils (neutropenia), including febrile neutropenia, which can lead to dangerous infections. Keep all appointments to have your blood checked. Get help right away if you have any of the following symptoms of blood disorders.

  • Fever
  • Shortness of breath
  • Pale or yellowish skin
  • Easy bruising or bleeding
  • Frequent infections
  • Unusual weakness or tiredness
  • Dizziness, lightheadedness, or feeling like you are about to pass out
  • Headache
  • Fast or abnormal heartbeat

Low Antibodies. Tecartus may cause you to have low levels of certain types of antibodies, called immunoglobulins. Low immunoglobulin levels could increase your risk for infection. Keep all appointments for blood tests after getting this medicine.

Cancer. Tecartus can cause a new cancer to develop. Tell your health care provider about any new symptoms that you may get.

Warnings & Precautions

Who should not use Tecartus?

Allergies to Ingredients. People who are allergic to any of the following should not use Tecartus.

  • Brexucabtagene autoleucel
  • Tecartus
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Tecartus.

What should I know about Tecartus before using it?

Tecartus is given by a health care provider in a hospital or clinic.

Tecartus is made using your own white blood cells, so it will take several weeks for the medicine to be ready. Talk with your health care provider about what to expect during the process.

Tecartus is given as a single dose. Your health care provider will give you certain medicines on a specific schedule before you receive Tecartus. Make sure to attend all appointments and take all medicines they give you as instructed.

Tecartus can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination for at least eight weeks after receiving Tecartus.

You should not donate blood, tissues, or organs after using Tecartus.

After using Tecartus, it is possible that blood tests will give you a false-positive test result for HIV. Tell every health care provider you see that you have received Tecartus.

What should I tell my health care provider before using Tecartus?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Tecartus is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Brain or nerve problems, such as seizures, stroke, or memory loss
  • Breathing or lung problems
  • Heart problems
  • Kidney or liver problems
  • Infection

Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines within six weeks before starting the treatment process for Tecartus, during treatment, and until your immune system recovers after Tecartus. Tell your health care provider about any vaccines you have recently received or have scheduled.

Pregnancy. Do not use Tecartus if you are pregnant or think you may be pregnant. It is not known if Tecartus may cause harm to a fetus, but it may cause serious problems if it reaches the fetus. Your health care provider will likely give you a pregnancy test before you use Tecartus. Tell your health care provider if you are pregnant or plan to become pregnant or if you get pregnant after receiving Tecartus.

Breastfeeding. It is not known if Tecartus passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Tecartus?

For more information about Tecartus, you can visit the drugmaker’s website at www.tecartus.com or call them at 844-454-5483.

Interactions

Does Tecartus interact with foods or drinks?

There are no known interactions between Tecartus and foods or drinks.

It is unknown if drinking alcohol will affect Tecartus, but heavy drinking can slow your immune response and make it harder for your body to fight infection and cancer.

Does Tecartus interact with other medicines (drug interactions)?

There are no known interactions between Tecartus and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Tecartus?

If you or someone else has used too much Tecartus, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Tecartus?

Tecartus is given by a health care provider in a hospital. Call them right away if you are going to miss your appointment for Tecartus or any of the other medicines you need before using Tecartus.

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