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Overview: Oxlumo is used for primary hyperoxaluria type 1 (PH1). It works by helping lower oxalate levels in plasma and urine (pee). Common side effects include redness, swelling, pain, itching, discoloration, and bruising near the injection site. This medicine is available as a liquid that is injected under the skin by a health care provider.

Uses

What is Oxlumo used for?

Oxlumo (lumasiran) is commonly used to treat primary hyperoxaluria type 1 (PH1). It helps reduce oxalate levels in plasma and urine (pee).

Oxlumo may also be used for other conditions as determined by your health care provider.

How does Oxlumo work (mechanism of action)?

People with primary hyperoxaluria type 1 have too much of a natural substance called oxalate. Too much oxalate can damage your kidneys. Oxlumo lowers the amount of an enzyme called glycolate oxidase in your liver. Lowering glycolate oxidase in your liver lowers the amount of oxalate your liver makes. Thus, Oxlumo works to lower oxalate levels.

How is Oxlumo supplied (dosage forms)?

Brands and other names

  • Oxlumo

Dosage forms and strengths

Oxlumo is available in an injectable form that is given by a health care provider.

How should I store Oxlumo?

Oxlumo is usually given by a health care provider in a hospital or clinic. In most cases, you will not store it at home.

However, some people who receive in-home nursing services may need to store Oxlumo at home. In this case, Oxlumo should be stored in the refrigerator or at room temperature, between 36 F and 77 F (2 C to 25 C). Keep in the original container until it is time for your injection.

Side Effects

What are the most common side effects of Oxlumo?

The most common side effects of Oxlumo are redness, swelling, pain, itching, discoloration, and bruising near the injection site. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of Oxlumo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Oxlumo?

While less common, the most serious side effects of Oxlumo are described below, along with what to do if they happen.

Severe Allergic Reactions. Oxlumo may cause allergic reactions, which can be serious. Stop using Oxlumo and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Oxlumo?

Allergies to Ingredients. People who are allergic to any of the following should not use Oxlumo.

  • Lumasiran
  • Oxlumo
  • Any of the ingredients in the specific product dispensed

Your health care provider can tell you all of the ingredients in Oxlumo.

What should I know about Oxlumo before using it?

Oxlumo is given by subcutaneous (under the skin) injection by a health care provider. In some cases, it may be given in your home by a nurse or other health care professional.

If you store Oxlumo at home and you keep it in the refrigerator, take special precautions to keep it away from children who also use the refrigerator. If you store Oxlumo at home at room temperature, keep out of the reach of children.

If you receive an Oxlumo injection on a dialysis day, it will be administered after hemodialysis.

Your health care provider will inject Oxlumo into the stomach, thigh, or side or back of the upper arms. They will use a different injection site each time. Tell your health care provider if your skin becomes red, scarred, or inflamed (swollen).

What should I tell my health care provider before using Oxlumo?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Oxlumo is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Oxlumo could affect pregnancy or harm an unborn baby. Tell your health care provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Oxlumo passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will advise you if you should use Oxlumo while breastfeeding.

How can I get more information about Oxlumo?

For more information about Oxlumo, you can visit the manufacturer’s website at www.oxlumo.com or call them at 877-256-9526.

Interactions

Does Oxlumo interact with foods or drinks?

There are no known interactions between Oxlumo and foods or drinks.

It is unknown if drinking alcohol will affect Oxlumo.

Does Oxlumo interact with other medicines (drug interactions)?

There are no known interactions between Oxlumo and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Oxlumo?

If you or someone else has used too much Oxlumo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Oxlumo?

If you miss a dose, it should be injected as soon as possible. Call your health care provider right away if you need to reschedule an appointment to receive your dose of Oxlumo. After receiving the missed dose, you can resume your regular monthly or quarterly dosing schedule from the time the missed dose is given.