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Overview: Klisyri is used to treat actinic keratosis of the face or scalp. Common side effects include itching and pain where you apply the medicine. Do not get Klisyri in, around, or near the eyes, mouth, or lips. To decrease the risk of getting Klisyri anywhere it should not be, wash your hands right after you apply it.

Uses

What is Klisyri used for?

Klisyri (tirbanibulin) is commonly used to treat actinic keratosis of the face or scalp. 

Klisyri may also be used for other conditions as determined by your health care provider.

How does Klisyri work (mechanism of action)?

Klisyri is classified as a microtubule inhibitor. Microtubules are involved in the process of cell growth and replication. Klisyri is applied directly to skin affected by actinic keratosis. By blocking the action of microtubules, Klisyri seems to reduce the growth of these actinic keratosis cells. 

How is Klisyri supplied (dosage forms)?

Brands and other names

  • Klisyri

Dosage forms and strengths

  • 1% topical ointment

How should I store Klisyri?

Klisyri should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Do not put Klisyri in the refrigerator or freezer.

Side Effects

What are the most common side effects of Klisyri?

The most common side effects of Klisyri are itching and pain where you apply the medicine. Tell your health care provider if you have itching or pain that bothers you. 

There may be other side effects of Klisyri that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canadaor by calling 866-234-2345.

What are the serious side effects of Klisyri?

While less common, the most serious side effects of Klisyri are described below, along with what to do if they happen.

Severe Allergic Reactions. Klisyri may cause allergic reactions, which can be serious. Stop using Klisyri and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, rash, or bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Eye Irritation. Klisyri can cause eye irritation if it gets into your eyes. Do not apply this medicine in, around, or near your eyes. Do not touch your eyes if you have Klisyri on your hands. Wash your hands with soap and water right after you apply Klisyri. If you accidentally get Klisyri in your eyes, flush them with water right away and get medical care as soon as possible.

Severe Skin Reactions. It is common to have some pain or itching where you apply Klisyri, but more severe skin reactions may occur. Call your health care provider if you develop any of the following symptoms or if you are not sure if your skin reaction is severe. 

  • Red, flaking, scaling, crusting, or swelling skin
  • Blisters, peeling, pus, ulcers, or breakdown of your skin

Warnings & Precautions

Who should not use Klisyri?

Allergies to Ingredients. People who are allergic to any of the following should not use Klisyri.

  • Klisyri
  • Tirbanibulin
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Klisyri.

What should I know about Klisyri before using it?

Do not use Klisyri unless it has been prescribed to you by a health care provider. Use it as prescribed. 

Do not share Klisyri with other people, even if they have the same condition as you. It may harm them.

Keep Klisyri out of the reach of children.

Klisyri is for use on the skin only. Only apply it where your health care provider tells you to. Do not get Klisyri in, around, or near the eyes, mouth, or lips. Do not touch your eyes while applying Klisyri. Wash your hands with soap and water right after you apply Klisyri. Avoid getting Klisyri in your eyes or any other areas after you apply it. If you accidentally get Klisyri in your eyes, flush your eyes with water right away and get medical care as soon as possible. 

Do not use more medicine than you need to cover the treatment area. You are more likely to have a severe skin reaction or other side effects if you use too much Klisyri or use it too often or for too long. 

Do not cover the treatment area after applying Klisyri, as this may irritate your skin. 

After applying Klisyri, avoid washing or touching the area for eight hours. After this time, you can wash the area with mild soap and water. 

Each packet of Klisyri is for one use only. After applying Klisyri, throw away the open packet, even if there is medicine left inside the packet.

What should I tell my health care provider before using Klisyri?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Klisyri is right for you.

In particular, make sure that you discuss any of the following.

Other Treatments. Tell your health care provider if you are being treated or have previously been treated for actinic keratosis with any other medicine, surgery, or procedure. Do not use Klisyri until your skin is healed from these other treatments.

Skin Problems. Tell your health care provider if you have any other skin problems in the treatment area.

Pregnancy. It is not known if or how Klisyri could affect pregnancy or harm a fetus. Tell your health care provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Klisyri passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Klisyri while breastfeeding.

How can I get more information about Klisyri?

For more information about Klisyri, you can visit the drugmaker’s website at www.klisyri.com or call them at 800-KLISYRI (800-554-7974).

Interactions

Does Klisyri interact with foods or drinks?

There are no known interactions between Klisyri and foods or drinks.

It is unknown if drinking alcohol will affect Klisyri.

Does Klisyri interact with other medicines (drug interactions)?

There are no known interactions between Klisyri and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Klisyri?

If you or someone else has used too much Klisyri, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Klisyri?

If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses.