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Overview: Zegalogue is a shot given under the skin to increase blood sugar levels in people with dangerously low levels. Common side effects may include nausea, vomiting, headaches, diarrhea, or pain where the needle went in. Make sure that your caregiver knows where you store Zegalogue and understands how to use it. Zegalogue must be used as soon as possible once you start to show signs of dangerously low blood sugar levels.

Uses

What is Zegalogue used for?

Zegalogue (dasiglucagon) is commonly used to increase blood sugar (glucose) levels in people with dangerously low glucose levels (severe hypoglycemia). Zegalogue is used only during emergencies. Anyone using Zegalogue should seek medical care right away.

Zegalogue may also be used for other conditions as determined by your health care provider.

How does Zegalogue work (mechanism of action)?

Zegalogue works by activating glucagon receptors in the liver. This causes the liver to break down stored sugar (glycogen) and release it into the bloodstream to increase blood sugar levels.

How is Zegalogue supplied (dosage forms)?

Brands and other names

  • Zegalogue

Dosage forms and strengths

  • 0.6 mg/0.6 mL single-dose prefilled syringe or autoinjector

How should I store Zegalogue?

Store Zegalogue in a refrigerator, between 36 F and 46 F (2 C and 8 C). It can also be stored at room temperature, between 59 F and 86 F (15 C and 30 C) for up to 12 months. If you store Zegalogue at room temperature, write the date on the protective case when you took it out of the refrigerator. This will help you know when to throw it away. Once Zegalogue has been stored at room temperature, you should not put it back in the refrigerator. Keep Zegalogue in the red case it comes in to protect it from light. Do not freeze it.

Side Effects

What are the most common side effects of Zegalogue?

The most common side effects of Zegalogue are listed below. These side effects may vary, depending on the age of the person that is being treated. Tell your health care provider if you have any of these side effects that bother you.

  • Nausea, vomiting, or diarrhea
  • Headache
  • Pain at or near where the needle went in

There may be other side effects of Zegalogue that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Zegalogue?

While less common, the most serious side effects of Zegalogue are described below, along with what to do if they happen.

Severe Allergic Reactions. Zegalogue may cause allergic reactions, which can be serious. Stop using Zegalogue and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Zegalogue?

Allergies to Ingredients. People who are allergic to any of the following should not use Zegalogue.

  • Dasiglucagon
  • Zegalogue 
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Zegalogue.

Pheochromocytoma. Zegalogue should not be used if you have a certain tumor in the adrenal gland known as a pheochromocytoma. Zegalogue may cause your blood pressure to get dangerously high if you have a pheochromocytoma. 

Pancreas Tumor. Zegalogue should not be used if you have a certain tumor in your pancreas known as an insulinoma. Zegalogue can cause too much insulin to release from the tumor, causing your blood sugar to drop too low again.

What should I know about Zegalogue before using it?

Do not use Zegalogue unless it has been prescribed to you by a health care provider. Use it as prescribed.

Zegalogue is injected under the skin. Make sure that your caregiver knows where you store Zegalogue and how to use it. You can share the “Instructions for Use” that come with your medicine to help with this. Zegalogue must be used as soon as possible once you start to show signs of dangerously low blood sugar. This is because low blood sugar can be deadly if not treated. If you have any questions, talk to your health care provider.

Zegalogue cannot be injected through clothing. Your caregiver may need to roll back or remove clothing to expose bare skin before injecting it.

Always get medical help right away after receiving Zegalogue. Your caregiver should call for emergency help as soon as they have given you a dose of Zegalogue. Then once you are conscious and able to safely eat or drink, they should give you a fast-acting source of sugar (fruit juice, etc.) and a long-acting source of sugar (crackers with cheese or peanut butter, etc.) to prevent your blood sugar from dropping again. 

If your blood sugar does not come up 15 minutes after receiving a dose of Zegalogue, your caregiver may need to give you another shot with a second Zegalogue prefilled syringe or autoinjector while waiting on emergency help to arrive. 

Tell your health care provider each time you use Zegalogue. They may need to change the dose of your diabetes medicines. 

Do not share Zegalogue with other people, even if they have the same condition as you. It may harm them.

Keep Zegalogue out of the reach of children. Since this medicine can be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.

Zegalogue is good for just one use. After a dose is given, it should be thrown away in a sharps container or in a household container made of heavy-duty plastic that is able to close tightly and is puncture- and leak-resistant. Get a new Zegalogue after using the medicine. This way, you will have one available in case you need it. 

You should also keep an eye on the expiration date of the product you have. Try to get a new one before it expires, so you always have one available in case you need it. 

What should I tell my health care provider before using Zegalogue?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Zegalogue is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Have not had food or water for a long time (prolonged fasting or starvation)
  • Problems with your adrenal gland, including reduced adrenal function (adrenal insufficiency)
  • Low blood sugar that will not go away (chronic hypoglycemia)
  • Latex allergy

Other Medicines and Supplements. Zegalogue may interact with other medicines and supplements. Before using Zegalogue, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Zegalogue could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Zegalogue passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Zegalogue while breastfeeding.

How can I get more information about Zegalogue?

For more information about Zegalogue, you can visit the drugmaker’s website at www.zegalogue.com or call them at 800-727-6500.

Interactions

Does Zegalogue interact with foods or drinks?

There are no known interactions between Zegalogue and foods or drinks.

It is unknown if drinking alcohol will affect Zegalogue.

Does Zegalogue interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using Zegalogue.

  • A beta-blocker, such as atenolol (Tenormin), metoprolol (Lopressor, Toprol XL, and others), or propranolol (Inderal LA, Innopran XL), which is a medicine that may be used for certain heart conditions or to lower blood pressure
  • Indomethacin, which is a nonsteroidal anti-inflammatory drug (NSAID) that may be used for pain and swelling
  • Warfarin, which is a blood thinner

This may not be a complete list of medicines that can interact with Zegalogue. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Zegalogue?

If you or someone else has used too much Zegalogue, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Zegalogue?

Zegalogue is used during emergencies only. Always get medical help right away after using a dose of Zegalogue.