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Lumakras is used to treat certain types of non-small-cell lung cancer and colorectal cancer. It helps stop certain cancer cells from growing and multiplying. Common side effects include diarrhea, muscle or bone pain, nausea, tiredness, coughing, skin rashes or dry skin, mouth sores, and changes in certain blood tests. Keep all appointments for bloodwork before and during treatment with Lumakras. Lung inflammation is a possible serious side effect with Lumakras. If you have new or worsening trouble breathing while taking Lumakras, get emergency help right away.

Uses

What is Lumakras used for?

Lumakras (sotorasib) is commonly used to treat certain types of non-small-cell lung cancer (NSCLC) and colorectal cancer.

Lumakras may also be used for other conditions as determined by your health care provider.

How does Lumakras work (mechanism of action)?

Some cancers have a certain type of protein that is not normal. Lumakras binds to part of this abnormal, or mutant, protein and keeps it from working. This helps to slow the growth of cancer cells caused by the mutant protein. The medicine does not have a significant effect on the normal form of the protein. Your health care provider can run a test to see if your cancer may respond to this medicine.

How is Lumakras supplied (dosage forms)?

Brands and other names

  • Lumakras

Dosage forms and strengths

  • 120 mg, 240 mg, 320 mg oral tablets

How should I store Lumakras?

Lumakras should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when you’re transporting it. Store it in a cool, dry place.

Side Effects

What are the most common side effects of Lumakras?

The most common side effects of Lumakras are listed below. These side effects may vary, depending on the condition that is being treated. Tell your health care provider if you have any of these side effects that bother you.

  • Diarrhea
  • Muscle or bone pain
  • Nausea
  • Tiredness
  • Liver damage (see below)
  • Coughing
  • Changes in certain blood tests
  • Skin rash or dry skin
  • Mouth sores

There may be other side effects of Lumakras that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Lumakras?

While less common, the most serious side effects of Lumakras are described below, along with what to do if they happen.

Severe Allergic Reactions. Lumakras may cause allergic reactions, which can be serious. Stop taking Lumakras and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking Lumakras. Keep all appointments to check your bloodwork. Call your health care provider right away if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine (pee)
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Lung Inflammation. Lumakras can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. Get emergency help if you have trouble breathing. Call your health care provider right away if you have any new or worsening cough or fever.

Warnings & Precautions

Who should not use Lumakras?

Allergies to Ingredients. People who are allergic to any of the following should not take Lumakras.

  • Lumakras
  • Sotorasib
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Lumakras.

What should I know about Lumakras before using it?

Do not take Lumakras unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Lumakras with other people, even if they have the same condition as you. It may harm them.

Keep Lumakras out of the reach of children.

Lumakras should be swallowed whole. Do not chew, crush, or split this medicine. If you cannot swallow Lumakras whole, you can dissolve it in a small glass of water and drink it. Ask your pharmacist or other health care provider for directions on how to do this properly.

If you ever need to take an antacid medicine, make sure to take Lumakras either four hours before or 10 hours after the antacid. Antacids may make Lumakras not work as well. See the Interactions section for more information, and ask your health care provider if you have any questions. 

What should I tell my health care provider before using Lumakras?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Lumakras is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Liver problems
  • Other lung or breathing problems, not including lung cancer

Other Medicines and Supplements. Lumakras may interact with other medicines and supplements. Before taking Lumakras, tell your health care provider about any prescription or OTC medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how Lumakras could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Lumakras passes into breast milk. Do not breastfeed while you are taking Lumakras and for one week after your last dose. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Lumakras?

For more information about Lumakras, you can visit the drugmaker's website at www.lumakras.com or call them at 800-772-6436.

Interactions

Does Lumakras interact with foods or drinks?

There are no known interactions between Lumakras and foods or drinks.

It is unknown if drinking alcohol will affect Lumakras, but heavy drinking can slow your immune response and make it harder for your body to fight cancer. Also, the risk of tiredness may be increased if you drink alcohol while taking Lumakras.

Does Lumakras interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or OTC medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Lumakras.

  • An antacid containing calcium, aluminum, magnesium, or iron
  • An H2 blocker, such as cimetidine (Tagamet), famotidine (Pepcid, Zantac), or nizatidine (Axid)
  • A proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (AcipHex)
  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
  • Rosuvastatin (Crestor), which is a medicine to lower cholesterol

Many other medicines may alter the blood levels of Lumakras, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Lumakras. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Lumakras?

If you or someone else has used too much Lumakras, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Lumakras?

If you miss a dose of Lumakras, take it as soon as you remember. If it has been more than six hours, skip the missed dose and only take the next dose at your regularly scheduled time the next day. Do not take double or extra doses.