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Brexafemme is used to treat or prevent vaginal yeast infections. Common side effects include diarrhea, nausea, vomiting, stomach pain, dizziness, headaches, and tiredness. Before taking Brexafemme, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. 

Uses

What is Brexafemme used for?

Brexafemme (ibrexafungerp) is commonly used to treat vaginal yeast infections and to prevent recurring vaginal yeast infections.

Brexafemme may also be used for other conditions as determined by your health care provider.

How does Brexafemme work (mechanism of action)?

Brexafemme is an antifungal medicine that kills certain types of fungi by disrupting their cell structure.

How is Brexafemme supplied (dosage forms)?

Brands and other names

  • Brexafemme

Dosage forms and strengths

  • 150 mg oral tablets

How should I store Brexafemme?

Brexafemme should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when you’re transporting it. Store it in a cool, dry place.

Side Effects

What are the most common side effects of Brexafemme?

The most common side effects of Brexafemme are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Diarrhea
  • Nausea and vomiting
  • Stomach pain
  • Dizziness
  • Headache
  • Kidney or bladder infections
  • Tiredness

There may be other side effects of Brexafemme that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Brexafemme?

While less common, the most serious side effects of Brexafemme are described below, along with what to do if they happen.

Severe Allergic Reactions. Brexafemme may cause allergic reactions, which can be serious. Stop taking Brexafemme and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Brexafemme?

Allergies to Ingredients. People who are allergic to any of the following should not take Brexafemme.

  • Ibrexafungerp
  • Brexafemme
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Brexafemme.

Pregnancy. Do not take Brexafemme if you are pregnant. If you become pregnant, contact your health care provider right away. See the Pregnancy subsection for more details.

What should I know about Brexafemme before using it?

Do not take Brexafemme unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Brexafemme with other people, even if they have the same condition as you. It may harm them.

Keep Brexafemme out of the reach of children.

If you are prescribed to take multiple doses of Brexafemme, your health care provider may perform a pregnancy test before each dose. Follow all instructions and keep all scheduled appointments to make sure that you are taking this medicine safely.

What should I tell my health care provider before using Brexafemme?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Brexafemme is right for you.

In particular, make sure that you discuss any of the following.

Other Medicines and Supplements. Brexafemme may interact with other medicines and supplements. Before taking it, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. You should not take Brexafemme if you are pregnant. Brexafemme may harm an unborn baby. You may need a negative pregnancy test before you can take Brexafemme. Follow any advice from your health care provider about using effective birth control. Tell your health care provider if you are pregnant or think you are pregnant. If you become pregnant while taking Brexafemme, you can report your pregnancy to the drugmaker by calling 888-982-7299. This is to collect safety information about the use of Brexafemme during pregnancy.

Breastfeeding. It is not known if Brexafemme passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should stop breastfeeding or stop taking Brexafemme.

How can I get more information about Brexafemme?

For more information about Brexafemme, you can visit the drugmaker’s website at www.scynexis.com or call them at 201-884-5485.

Interactions

Does Brexafemme interact with foods or drinks?

There are no known interactions between Brexafemme and foods or drinks.

It is unknown if drinking alcohol will affect Brexafemme, but heavy drinking can slow your immune response and make it harder for your body to fight infections.

Does Brexafemme interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Brexafemme.

  • Fluconazole (Diflucan), itraconazole (Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), or voriconazole (Vfend), which are medicines used for fungal infections
  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • Carbamazepine (Carbatrol, Tegretol, and others), which is a medicine commonly used to treat seizures or nerve pain
  • Phenytoin (Dilantin, Phenytek, and others), which is a medicine to control seizures
  • St. John’s wort, which is a supplement that may be used for depression
  • A barbiturate, such as butalbital, phenobarbital, or primidone, which is a medicine that may be used to treat insomnia, migraines, or seizures
  • Efavirenz or etravirine, which are medicines used for HIV
  • Bosentan (Tracleer), which is a medicine that treats high blood pressure in the vessels that carry blood to the lungs

Many other medicines may alter the blood levels of Brexafemme. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Brexafemme. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Brexafemme?

If you or someone else has used too much Brexafemme, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Brexafemme?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.