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Overview: Lunsumio is a medicine used to treat follicular lymphoma. It uses the body's own immune system to attack the cancer cells. The most common side effects of Lunsumio are feeling tired, rash, fever, and headache. Call your healthcare provider right away if you get a fever, nausea, tremors, confusion, or trouble breathing, speaking, or walking.

Uses

What is Lunsumio used for?

Lunsumio (mosunetuzumab-axgb) is commonly used to treat a type of lymphoma called follicular lymphoma. 

Learn more about How Lunsumio Works to Treat Follicular Lymphoma.

Lunsumio may also be used for other conditions as determined by your healthcare provider.

How does Lunsumio work (mechanism of action)?

Lunsumio is a type of medicine called a bispecific antibody, which attaches to two types of cells. Lunsumio attaches to CD20 proteins on lymphoma cells, and to CD3 proteins on immune cells called T cells. This activates the T cells, makes them multiply, and helps them release chemicals that destroy the lymphoma cells.

How is Lunsumio supplied (dosage forms)?

Brands and other names

  • Lunsumio

Dosage forms and strengths

Lunsumio is available in an injectable form that is given by a healthcare provider.

How should I store Lunsumio?

Lunsumio is usually given by a healthcare provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Lunsumio?

The most common side effects of Lunsumio are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

There may be other side effects of Lunsumio that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Lunsumio?

While less common, the most serious side effects of Lunsumio are described below, along with what to do if they happen.

Severe Allergic Reactions. Lunsumio may cause allergic reactions, which can be serious. Stop using Lunsumio and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Cytokine Release Syndrome. Lunsumio can cause a dangerous and sometimes life-threatening problem called cytokine release syndrome (CRS). CRS occurs when your immune system responds too much to medicines or infection. CRS may happen right away or several days after you get Lunsumio. Get emergency help if you have any of the following symptoms of CRS. 

  • Fever or chills
  • Fast or racing heart
  • Dizziness or feeling lightheaded
  • Trouble breathing
  • Severe nausea, vomiting, or diarrhea
  • Severe headache

Neurologic Problems. Lunsumio can cause a condition called immune effector cell-associated neurotoxicity syndrome (ICANS). Get emergency help if you get any of the following symptoms.

  • Confusion, forgetfulness, or trouble paying attention
  • Seizures
  • Balance problems or trouble walking
  • Trouble talking, reading, or writing 
  • Tremors
  • Sleepiness or trouble sleeping
  • Numbness and tingling of your arms, legs, hands, or feet

Infections. Lunsumio can increase your risk of infections, including serious and life-threatening infections. Call your healthcare provider right away if you have an infection or any of the following symptoms.

  • Burning or stinging when you pee 
  • Cough or coughing up blood
  • Fever, sweats, chills, or muscle aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Sore throat
  • General feeling of being unwell, tired, or not having your usual energy

Blood Disorders. Lunsumio can cause blood disorders, such as low levels of red blood cells (anemia), low levels of neutrophils (neutropenia), low platelet levels (thrombocytopenia).  Keep all appointments to have your blood checked. Tell your healthcare provider right away if you have any of the following symptoms of blood disorders.

  • Pale or yellowish skin
  • Easy bruising or bleeding
  • Frequent infection
  • Unusual weakness or tiredness
  • Dizziness, lightheadedness, or feeling like you are about to pass out
  • Headache
  • Fast or abnormal heartbeat
  • Cold hands and feet
  • Fever, chills, or sweats
  • Sore throat, cough, or shortness of breath
  • Mouth or throat sores

Tumor Flare. Lunsumio can cause your tumor to grow or cause your cancer symptoms to get worse, which is called tumor flare. Call your healthcare provider right away if you have any of the following symptoms of tumor flare.

  • Lymph nodes that are sore or swollen
  • Pain or swelling at your tumor site
  • Chest pain
  • Cough
  • Trouble breathing

Warnings & Precautions

Who should not use Lunsumio?

Allergies to Ingredients. People who are allergic to any of the following should not receive Lunsumio.

  • Lunsumio
  • Mosunetuzumab-axgb
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Lunsumio.

What should I know about Lunsumio before using it?

Lunsumio will be given to you by a healthcare provider as an intravenous injection. Your healthcare provider will tell you how many treatments you will need. 

Keep all appointments to check your blood work so that your healthcare provider can check for side effects.

Lunsumio will be given to you by a healthcare provider in a hospital, clinic, or infusion center. They will store and prepare the medicine for your dose.

Do not drive or do other activities that require alertness or coordination until you know how Lunsumio affects you.

What should I tell my healthcare provider before using Lunsumio?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Lunsumio is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have or have had any of the following.

Other Medicines and Supplements. Lunsumio may interact with other medicines and supplements. Before using Lunsumio, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Lunsumio may cause harm to an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. If you become pregnant, stop using Lunsumio right away and contact your healthcare provider. If you can become pregnant, use effective birth control while using Lunsumio and for at least three months after your last dose.

Breastfeeding. It is not known if Lunsumio passes into breast milk. Do not breastfeed while using Lunsumio and for three months after your last dose. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Lunsumio?

For more information about Lunsumio, you can visit the manufacturer’s website at www.lunsumio.com or call them at 877-436-3683.

Interactions

Does Lunsumio interact with foods or drinks?

There are no known interactions between Lunsumio and foods or drinks.

It is unknown if drinking alcohol will affect Lunsumio. The risk of dizziness or drowsiness may be increased if you drink alcohol while using Lunsumio.

Does Lunsumio interact with other medicines (drug interactions)?

Lunsumio may alter the blood levels of some medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Lunsumio?

If you or someone else has used too much Lunsumio, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Lunsumio?

Lunsumio is usually given by a healthcare provider in a hospital. Your healthcare provider will make sure you are receiving Lunsumio as scheduled.

If you miss an appointment to get your Lunsumio dose, call to make another appointment as soon as possible. 

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