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Overview: Rebyota is used after antibiotic treatment for recurrent infection with Clostridioides difficile to prevent another C. difficile infection. Rebyota works by providing good bacteria in your gut. Common side effects include stomach pain, diarrhea, swelling of the stomach area, gas, and nausea. Rebyota is inserted into your rectum by a health care provider. If you are given an antibiotic to take by mouth within eight weeks of getting this medicine, tell the health care provider that you got Rebyota.

Uses

What is Rebyota used for?

Rebyota (fecal microbiota, live-jslm) is commonly used after antibiotic treatment for recurrent Clostridioides difficile infection to prevent future episodes.

Rebyota may also be used for other conditions as determined by your health care provider.

See also: Vowst

How does Rebyota work (mechanism of action)?

Rebyota provides bacteria to your gut after you have been treated for C. difficile, which may help prevent the C. difficile infection from coming back.

How is Rebyota supplied (dosage forms)?

Brands and other names

  • Rebyota

Dosage forms and strengths

  • 150 mL bottle, suspension for rectal use

How should I store Rebyota?

Rebyota is usually given by a health care provider in a hospital or clinic. If you will store Rebyota at home, follow the instructions given by your health care provider.

Side Effects

What are the most common side effects of Rebyota?

The most common side effects of Rebyota are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Stomach pain
  • Diarrhea
  • Swelling of your stomach area
  • Gas
  • Nausea

There may be other side effects of Rebyota that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Rebyota?

While less common, the most serious side effects of Rebyota are described below, along with what to do if they happen.

Severe Allergic Reactions. Rebyota may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Risk of Infection. The process to make Rebyota involves the use of human substances. It is possible that these substances may carry germs that can cause infections. While steps are taken to reduce this risk, there is still a small chance you could get an infection. Some infections may not cause symptoms. Keep all medical appointments after using Rebyota, so your health care provider can monitor your health. Talk with your health care provider about any concerns you may have.

Warnings & Precautions

Who should not use Rebyota?

Allergies to Ingredients. People who are allergic to any of the following should not use Rebyota.

  • Fecal microbiota, live-jslm
  • Rebyota
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Rebyota.

What should I know about Rebyota before using it?

Rebyota is usually given by a health care provider in a hospital or clinic. The medicine is inserted into your rectum.

Make sure to finish your antibiotic treatment for C. difficile before you get Rebyota. Your health care provider will let you know when you can get Rebyota after you finish your antibiotic treatment. Talk to your health care provider if you have any questions about when you will receive Rebyota.

No laxatives are required before you receive Rebyota. Your health care provider may ask you to empty your bladder and bowels before you are given the medicine.

Tell your health care provider if you have three or more loose bowel movements a day (24 hours) for two consecutive days after you receive Rebyota.

Tell any health care provider you see that you got Rebyota and when you got it. In general, you should not get any antibiotic that you take by mouth for up to eight weeks after you get Rebyota.

What should I tell my health care provider before using Rebyota?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Rebyota is right for you.

In particular, make sure that you discuss any of the following.

Food Allergies. Rebyota is made using other people’s stool (poop) and may contain food allergens since donors are not asked to follow any dietary restrictions. The potential for Rebyota to cause reactions in people with food allergies is unknown. Tell your health care provider if you have any food allergies.

Drug Interactions. Rebyota should not be used while you are using certain other medicines. Before using Rebyota, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.  See the Interactions section for more details.

Pregnancy. Rebyota is not absorbed by the body and is not expected to reach the baby. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should use Rebyota while you are pregnant or trying to get pregnant.

Breastfeeding. Rebyota is not absorbed by the body and is not expected to reach the baby through breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Rebyota while breastfeeding.

How can I get more information about Rebyota?

For more information about Rebyota, you can visit the drugmaker’s website at www.rebyota.com or call them at 888-337-7464.

Interactions

Does Rebyota interact with foods or drinks?

There are no known interactions between Rebyota and foods or drinks.

There are no known interactions between Rebyota and alcohol, but heavy drinking can slow your immune response and make it harder for your body to fight infection.

Does Rebyota interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are taking an antibiotic. Antibiotics can make Rebyota not work as well. So, you have to wait a period of time after stopping your antibiotic for C. difficile to get Rebyota.

This may not be a complete list of medicines that can interact with Rebyota. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Rebyota?

If you or someone else has used too much Rebyota, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Rebyota?

Rebyota is usually given as a single dose by a health care provider in a hospital or clinic. If you miss your appointment to get your Rebyota dose, call to make another appointment as soon as possible.

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