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Overview: Krazati is used to treat certain types of non-small cell lung cancer or colorectal cancer. It helps to stop cancer cells from growing and multiplying. The most common side effects are nausea, vomiting, diarrhea, and tiredness. Call your healthcare provider right away if you get a new or worse cough, stomach pain, nausea, diarrhea, or have any trouble breathing.

Uses

What is Krazati used for?

Krazati (adagrasib) is commonly used to treat certain types of non-small cell lung cancer (NSCLC) or colorectal cancer. 

Krazati may also be used for other conditions as determined by your healthcare provider.

How does Krazati work (mechanism of action)?

Some types of cancer have a protein that is not normal. Krazati binds to part of this abnormal or mutant protein and keeps it from working. The medicine does not affect the normal form of the protein. Krazati may slow the growth of cancer cells with the mutant protein. Your healthcare provider can run a test to see if your cancer may respond to this medicine.

How is Krazati supplied (dosage forms)?

Brands and other names

  • Krazati

Dosage forms and strengths

  • 200 mg oral tablets

How should I store Krazati?

Krazati should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Krazati?

The most common side effects of Krazati are listed below. These side effects may vary depending on the condition that is being treated. Tell your healthcare provider if you have any of these side effects that bother you.

  • Nausea, diarrhea, or vomiting
  • Tiredness
  • Muscle and bone pain
  • Increased liver function tests 
  • Kidney problems
  • Swelling
  • Decreased appetite
  • Trouble breathing

There may be other side effects of Krazati that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Krazati?

While less common, the most serious side effects of Krazati are described below, along with what to do if they happen.

Severe Allergic Reactions. Krazati may cause allergic reactions, which can be serious. Stop taking Krazati and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Stomach and Intestinal Problems. Krazati can commonly cause nausea, diarrhea, and vomiting. If you are given medicine to prevent or treat stomach and intestinal problems, take it exactly as your healthcare provider tells you. Sometimes, severe problems like stomach bleeding or inflamed, narrowed, or blocked intestines may happen. Call your healthcare provider right away if you have any of the following symptoms.

  • Diarrhea that does not stop
  • Vomit with blood that looks like coffee grounds
  • Coughing up blood or blood clots
  • Black or tarry poop
  • Feel faint

Heart Rhythm Changes. Krazati may cause a rare, dangerous heart rhythm problem called QT prolongation and torsades de pointes. Some people have a higher risk of this, including people who are older, have other people in their family who have had these conditions, have low potassium or magnesium levels, or who take medicines that can prolong the QT interval. Tell your healthcare provider right away if you faint, feel dizzy, or have changes in your heart rate or rhythm, such as a fast or skipping heartbeat.

Liver Damage (Hepatotoxicity). Liver damage, also called hepatotoxicity, can happen when taking Krazati. Keep all appointments to have your blood checked. Call your healthcare provider right away if you have any of the following signs or symptoms of liver problems.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine (pee)
  • Your skin or the white part of your eyes turns yellow (also called jaundice)

Lung Inflammation. Krazati can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. Get emergency help if you have trouble breathing. You may also have a cough, fever, shortness of breath, or chest pain.

Warnings & Precautions

Who should not use Krazati?

Allergies to Ingredients. People who are allergic to any of the following should not take Krazati.

  • Krazati
  • Adagrasib
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Krazati.

What should I know about Krazati before using it?

Do not take Krazati unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Do not share Krazati with other people, even if they have the same condition as you. It may harm them.

Keep Krazati out of the reach of children.

Take Krazati at about the same time(s) each day. Do not chew, crush, or cut Krazati before taking it. 

Krazati may make it difficult for you to get pregnant or get your partner pregnant. If you have concerns, talk to your healthcare provider.

What should I tell my healthcare provider before using Krazati?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Krazati is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

Pregnancy. It is not known if or how Krazati could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. Do not breastfeed while you take Krazati and for one week after your last dose. It is not known if Krazati passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Krazati?

For more information about Krazati, you can visit the manufacturer’s website at www.krazati.com or call them at 866-457-2928.

Interactions

Does Krazati interact with foods or drinks?

There are no known interactions between Krazati and foods or drinks.

It is unknown if drinking alcohol will affect Krazati, but heavy drinking can slow your immune response and make it harder for your body to fight cancer. Also, the risk of tiredness may be increased if you drink alcohol while taking Krazati.

Does Krazati interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Krazati.

  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • Itraconazole (Sporanox, Tolsura), which is a medicine used for fungal infections
  • Warfarin, which is a blood thinner
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
  • Midazolam (Siezalam), which is a medicine used for seizures
  • Medicines that can cause QT prolongation, which is a potentially dangerous heart rhythm problem

Many other medicines may alter the blood levels of Krazati, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Krazati. Always check with your healthcare provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Krazati?

If you or someone else has used too much Krazati, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Krazati?

If you miss a dose of Krazati, take it as soon as you remember. If it has been more than four hours since the missed dose, skip the missed dose and only take the next dose. If you vomit after taking this medicine, just take the next dose when it is due. Do not take double or extra doses.