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Overview: Rezzayo is an intravenous (IV) medicine used to treat certain fungal infections. Common side effects include fever, diarrhea, constipation, nausea, vomiting, and stomach pain. Serious side effects are less likely but may include infusion reactions and liver damage. Rezzayo can cause you to be sensitive to the sun. If you need to be in sunlight, wear sunscreen, a hat, and clothing that covers your skin.

Uses

What is Rezzayo used for?

Rezzayo (rezafungin) is an antifungal medicine commonly used to treat certain Candida fungal infections (candidiasis), including infections in your blood.

Rezzayo may also be used for other conditions as determined by your health care provider.

Rezzayo may not be appropriate for some of the infections listed above, depending on which germs are causing the infection. Fungi in some locations may have developed resistance to rezafungin, which will make it not work as well.

How does Rezzayo work (mechanism of action)?

Rezzayo is an antifungal medicine that kills certain types of fungi by disrupting their cell structure.

How is Rezzayo supplied (dosage forms)?

Brands and other names

  • Rezzayo
  • rezafungin

Dosage forms and strengths

Rezzayo is available in an injectable form that is given by a health care provider.

How should I store Rezzayo?

Rezzayo is usually given by a health care provider in a hospital or clinic. If you will store Rezzayo at home, follow the instructions given by your health care provider.

Side Effects

What are the most common side effects of Rezzayo?

The most common side effects of Rezzayo are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Fever
  • Low potassium, magnesium, and phosphate levels
  • Diarrhea or constipation
  • Anemia
  • Nausea and vomiting
  • Stomach pain

There may be other side effects of Rezzayo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Rezzayo?

While less common, the most serious side effects of Rezzayo are described below, along with what to do if they happen.

Severe Allergic Reactions. Rezzayo may cause allergic reactions, which can be serious. Stop using Rezzayo and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infusion Reactions. Rezzayo can cause reactions that can be serious when it is given to you. Your infusion may need to be slowed or stopped if you have these reactions. Tell your health care provider right away if you have any of the following symptoms when you get your infusion.

  • Flushing
  • Warm sensation
  • Hives
  • Nausea
  • Chest tightness

Sensitivity to Sunlight. Your skin may be very sensitive to light from the sun and devices that give off similar light, such as sunlamps and tanning beds, while you are using Rezzayo. This is called photosensitivity. Use sunscreen and wear a hat and clothes that cover your skin if you need to be in the sunlight. Exposure to this kind of light, even for a short time, can cause your skin to be severely sunburned, blistered, or swollen. Tell your health care provider right away if any of these happen.

Liver Damage. Liver damage, also called hepatotoxicity, can happen when using Rezzayo. Keep all appointments, including lab appointments, while you are using Rezzayo. Call your health care provider right away if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine (pee)
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Warnings & Precautions

Who should not use Rezzayo?

Allergies to Ingredients. People who are allergic to any of the following should not use Rezzayo.

  • Rezafungin
  • Rezzayo
  • Any other medicine known as an echinocandin
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Rezzayo.

What should I know about Rezzayo before using it?

Rezzayo is usually given by a health care provider in a hospital or clinic. 

Rezzayo can make your skin more sensitive to light from the sun, sunlamps, and tanning beds. This is called photosensitivity. Exposure to this light can cause severe sunburns, blisters, and swelling. If you need to be in sunlight, wear sunscreen, a hat, and clothing that covers your skin.

What should I tell my health care provider before using Rezzayo?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Rezzayo is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Rezzayo could affect pregnancy or harm an unborn baby. Tell your health care provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Rezzayo passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will advise you if you should use Rezzayo while breastfeeding.

How can I get more information about Rezzayo?

For more information about Rezzayo, you can visit the manufacturer’s website at rezzayo.com or call them at 844-633-6568.

Interactions

Does Rezzayo interact with foods or drinks?

There are no known interactions between Rezzayo and foods or drinks.

It is unknown if drinking alcohol will affect Rezzayo, but heavy drinking can slow your immune response and make it harder for your body to fight infection.

Does Rezzayo interact with other medicines (drug interactions)?

There are no known interactions between Rezzayo and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Rezzayo?

If you or someone else has used too much Rezzayo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Rezzayo?

Rezzayo is usually given by a health care provider in a hospital or clinic. Your health care provider will make sure you are receiving Rezzayo as scheduled. If you miss an appointment to get your Rezzayo dose, call to make another appointment as soon as possible.