Omvoh is used to treat ulcerative colitis and Crohn’s disease. Common side effects of Omvoh include infections, rash, headache, joint pain, and itching, swelling, pain, or redness at the injection site. The first doses of the medicine are given through a vein in your arm (intravenous infusion) in a healthcare facility. After these doses and being trained, you can use it at home by injecting it under the skin. Before starting Omvoh, tell your healthcare provider about any vaccines you have recently received or have scheduled.
Uses
What is Omvoh used for?
Omvoh (mirikizumab-mrkz) is commonly used to treat the following conditions.
Learn more about Omvoh for ulcerative colitis.
Omvoh may also be used for other conditions as determined by your healthcare provider.
How does Omvoh work (mechanism of action)?
Omvoh works by blocking the effect of a substance called interleukin-23 (IL-23). This substance is normally made by your body and is part of your body’s response to inflammation. Blocking this substance can help treat the symptoms of ulcerative colitis or Crohn’s disease.
How is Omvoh supplied (dosage forms)?
Brands and other names
- Omvoh
Dosage forms and strengths
- 100 mg/mL single-dose, prefilled pens or syringes
- 200 mg/mL single-dose, prefilled pens or syringes
Omvoh is available in an injectable form that is given by a healthcare provider.
How should I store Omvoh?
Omvoh should be stored in the original carton (to protect from light) in a refrigerator between 36 F to 46 F (2 C to 8 C). Do not freeze or shake it. If needed, Omvoh may be stored at room temperature, up to 86 F (30 C), for up to two weeks, in the original carton. Once stored at room temperature, it should not be returned to the refrigerator. Once stored at room temperature, throw away any unused medicine after two weeks.
Side Effects
What are the most common side effects of Omvoh?
The most common side effects of Omvoh are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Infection in the nose or throat, sore throat, or common cold symptoms
- Joint pain
- Pain, itching, swelling, or redness near the injection site
- Rash
- Headache
- Herpes virus infection
- Increased liver function tests
There may be other side effects of Omvoh that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Omvoh?
While less common, the most serious side effects of Omvoh are described below, along with what to do if they happen.
Severe Allergic Reactions. Omvoh may cause allergic reactions, which can be serious. Stop using Omvoh and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart or pounding in the chest
- Tightness in your chest
- Sweating
- Swelling of the face, lips, eyelids, mouth, tongue, or throat
- Difficulty swallowing or throat tightness
- Itching, skin redness, or pale red bumps on the skin called hives
- Dizziness, feeling lightheaded, or fainting
- Fever or general ill feeling
- Swollen lymph nodes
- Stomach cramps
- Nausea or vomiting
- Joint pain
Infections. Omvoh can increase your risk of infections, including serious infections, including tuberculosis. Your healthcare provider may check to make sure you do not have tuberculosis before starting Omvoh. Call your healthcare provider right away if you have an infection or any of the following symptoms.
- Fevers, sweats, or chills
- Cough or shortness of breath
- Blood in your mucus (phlegm)
- Headache
- Muscle aches and pains or other flu-like symptoms
- Warm, red, or painful skin or sores on your body
- Weight loss
- Nausea, vomiting, diarrhea, or stomach pain
- Burning when peeing or peeing more frequently than usual
Liver Damage (Hepatotoxicity). Liver damage, also called hepatotoxicity, can happen when using Omvoh. Keep all appointments to have your blood checked. Call your healthcare provider right away if you have any of the following symptoms of liver damage.
- Nausea or vomiting
- Stomach or belly pain
- Weakness or unusual tiredness
- Unexplained rash
- Loss of appetite
- Dark-colored urine
- Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
Warnings & Precautions
Who should not use Omvoh?
Allergies to Ingredients. People who are allergic to any of the following should not use Omvoh.
- Omvoh
- Mirikizumab-mrkz
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Omvoh.
What should I know about Omvoh before using it?
Do not use Omvoh unless it has been prescribed to you by a healthcare provider. Use it as prescribed.
Do not share Omvoh with other people, even if they have the same condition as you. It may harm them.
Keep Omvoh out of the reach of children. Since this medicine must be kept in the refrigerator, take special precautions to keep it away from children who also use the refrigerator.
The first doses of Omvoh are given through a vein in your arm (intravenous infusion) in a hospital or clinic. After these doses, the medicine can be injected under the skin at home. Read and follow the “Instructions for Use” that come with your medicine. Make sure that you or a caregiver understands how to properly prepare and use Omvoh. If you have any questions, ask your healthcare provider.
What should I tell my healthcare provider before using Omvoh?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Omvoh is right for you.
In particular, make sure that you discuss any of the following.
Vaccines. Talk with your healthcare provider about any vaccines that you may need. You should not receive certain vaccines right before or while using Omvoh. Tell your healthcare provider about any vaccines you have recently received or have scheduled.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Infection
- Have, are being treated for, have history of, or have been in close contact with someone who has tuberculosis
- Liver problems
Pregnancy. It is not known if or how Omvoh could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. If you become pregnant while using Omvoh, you can sign up for the pregnancy registry by calling the manufacturer at 800-545-5979. This registry collects safety information about the use of Omvoh during pregnancy.
Breastfeeding. It is not known if Omvoh passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Omvoh while breastfeeding.
How can I get more information about Omvoh?
For more information about Omvoh, you can visit the manufacturer’s website at www.omvoh.lilly.com/ or call them at 844-4-OMVOH4 (844-466-8644).
Interactions
Does Omvoh interact with foods or drinks?
There are no known interactions between Omvoh and foods or drinks.
It is unknown if drinking alcohol will affect Omvoh. Both alcohol and Omvoh can cause liver damage. If you drink alcohol while using Omvoh your risk for liver damage may be higher.
Does Omvoh interact with other medicines (drug interactions)?
There are no known interactions between Omvoh and other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
Overdose/Missed Dose
What should I do if I accidentally use too much Omvoh?
If you or someone else has used too much Omvoh, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Omvoh?
If you miss a dose, use it as soon as you remember. Take your next dose in four weeks. Do not use double or extra doses. If you are unsure about when to use Omvoh, talk to your healthcare provider.