6 mins read

Uses

What is Winrevair used for?

Winrevair (sotatercept-csrk) is commonly used to treat pulmonary arterial hypertension (PAH). PAH is high blood pressure in the blood vessels (pulmonary arteries) that go to your lungs from your heart. The arteries may be narrowed or blocked, which makes it harder for blood to flow through your heart and lungs.

Learn more about Winrevair for pulmonary arterial hypertension.

Winrevair may also be used for other conditions as determined by your healthcare provider.

How does Winrevair work (mechanism of action)?

Winrevair binds to certain substances and blocks signals in the body that may contribute to the progression of pulmonary arterial hypertension. Winrevair can help improve your ability to exercise, reduce the severity of PAH, and lower your risk of having certain problems or worsening symptoms from PAH.

How is Winrevair supplied (dosage forms)?

Winrevair is available in the following dosage forms that are injected under the skin.

  • 45 mg injection kit
  • 60 mg injection kit
  • 90 mg injection kit (2 x 45 mg vials)
  • 120 mg injection kit (2 x 60 mg vials)

How should I store Winrevair?

Winrevair should be stored in the refrigerator, between 36 F to 46 F (2 C to 8 C). Do not freeze. Keep it in the original carton to protect it from light.

When you are ready to use Winrevair, you may keep it out of the refrigerator at a temperature of up to 77 F (25 C) for up to 24 hours.

Side Effects

What are the most common side effects of Winrevair?

The most common side effects of Winrevair are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Headache
  • Nosebleed
  • Rash
  • Spider veins on the skin
  • Diarrhea
  • Dizziness
  • Skin redness

There may be other side effects of Winrevair that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Winrevair?

While less common, the most serious side effects of Winrevair are described below, along with what to do if they happen.

Increased Red Blood Cells. Winrevair may increase levels of red blood cells, also called erythrocytosis. This can increase the amount of hemoglobin, which is a protein in red blood cells that carries oxygen. In severe cases, it may increase your risk for blood clots. Keep all appointments to have your blood checked, and tell your healthcare provider right away if you have any of the following symptoms of erythrocytosis.

  • Blurred vision
  • Headaches
  • Confusion
  • Itching
  • Weakness or tiredness

Severely Low Platelet Levels. Winrevair can cause you to have a severely low number of platelets in your blood, also called thrombocytopenia. Platelets help to form blood clots. Having a low level of platelets may increase your risk of bleeding. Keep all appointments to have your blood checked, and tell your healthcare provider if you have any of the following symptoms of low platelet levels.

  • Easy bruising or bleeding
  • Bleeding that does not stop
  • Nosebleeds

Severe Bleeding. Winrevair can increase your risk of severe bleeding that can lead to death. Some patients with serious bleeding may need a blood transfusion or surgery. Get medical help right away if you have any of the following signs of severe bleeding while taking Winrevair.

  • Pink, red, or brown urine (pee)
  • Vomit with blood that looks like coffee grounds
  • Red or black stools (looks like tar)
  • Coughing up blood or blood clots
  • Abnormally heavy menstrual periods
  • Persistent headaches or severe back pain
  • Nausea, dizziness, or weakness
  • Persistent stomach pain

Fertility Problems. Winrevair may impair fertility in females and males, which may affect you or your partner’s ability to become pregnant. Talk to your healthcare provider if you have concerns about this.

Warnings & Precautions

Who should not use Winrevair?

Allergies to Ingredients. People who are allergic to any of the following should not use Winrevair.

  • Winrevair
  • Sotatercept
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Winrevair.

What should I know about Winrevair before using it?

Do not use Winrevair unless it has been prescribed to you by a healthcare provider. Use it as prescribed.

Do not share Winrevair with other people, even if they have the same condition as you. It may harm them.

Keep Winrevair out of the reach of children.

Winrevair can cause dizziness. Do not drive or do other activities that require alertness or coordination until you know how Winrevair affects you.

You will inject Winrevair under your skin (subcutaneously). See the “Instructions for Use” booklet that comes with your prescription for details about how to prepare and inject your dose. Ask your healthcare provider if you are unsure how to prepare Winrevair, measure your dose, select an injection site, or inject Winrevair under your skin. Do not inject Winrevair if more than 4 hours have passed since you prepared it.

You will need to have blood tests before starting Winrevair and regularly during treatment. Keep all appointments to have your blood checked. Your dose of Winrevair may be adjusted based on these tests.

What should I tell my healthcare provider before using Winrevair?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Winrevair is right for you.

In particular, make sure that you discuss any of the following.

Blood Disorders. Tell your healthcare provider if you have had any blood disorders or any abnormal blood test results. Your healthcare provider will do blood tests before and during treatment with Winrevair.

Pregnancy. Winrevair may cause harm to an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider should do a pregnancy test before starting Winrevair. You will need to use an effective form of birth control while using Winrevair and for at least 4 months after your last dose. Ask your healthcare provider about effective forms of birth control. Tell your healthcare provider right away if you have unprotected sex or if you think your birth control has failed. If you have used Winrevair while pregnant, call 877-888-4231. This helps collect safety information about the use of Winrevair during pregnancy.

Breastfeeding. It is unknown if Winrevair passes into breast milk. Do not breastfeed while you are using Winrevair or for 4 months after your last dose. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. If you have used Winrevair while breastfeeding, call 877-888-4231. This helps collect safety information about the use of Winrevair while breastfeeding.

Other Medicines and Supplements. Winrevair may interact with other medicines and supplements. Before using Winrevair, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

How can I get more information about Winrevair?

For more information about Winrevair, you can visit the manufacturer’s website at www.winrevair.com or call them at 877-888-4231.

Interactions

Does Winrevair interact with foods or drinks?

There are no known interactions between Winrevair and foods or drinks.

It is unknown if drinking alcohol will affect Winrevair. The risk of dizziness may be increased if you drink alcohol while taking Winrevair. Both Winrevair and alcohol may also increase your risk of bleeding. It is best to limit the amount of alcohol you drink.

Does Winrevair interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using Winrevair.

  • A blood thinner, which is a medicine used to treat or prevent blood clots
  • A prostacyclin, such as epoprostenol (Flolan, Veletri), iloprost (Ventavis), or treprostinil (Orenitram, Remodulin, Tyvaso), which are also used to treat pulmonary arterial hypertension

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Winrevair?

If you or someone else has used too much Winrevair, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Winrevair?

If you miss a dose of Winrevair and it is within 3 days of your scheduled dose, use it as soon as you remember. You can keep your original dosing schedule for the next dose. Do not take double or extra doses.

If you miss your dose and it has been more than 3 days since your scheduled dose, call your healthcare provider. You may need to adjust your dosing schedule.

Look up another drug