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Tecentriq Hybreza is used to treat various types of cancers. It is a type of immunotherapy that works by helping your immune system find and attack cancer cells. Common side effects include cough, tiredness, shortness of breath, decreased appetite, and muscle or bone pain. Tecentriq Hybreza may cause your immune system to attack healthy tissues or organs, causing inflammation. This can lead to serious or even life-threatening problems. Keep all appointments to check your blood work. Tell your health care provider right away if you have any new or worsening symptoms.

Uses

What is Tecentriq Hybreza used for?

Tecentriq Hybreza (atezolizumab/hyaluronidase-tqjs) is commonly used to treat certain cancers, including the following. 

Tecentriq Hybreza may also be used for other conditions as determined by your health care provider.

How does Tecentriq Hybreza work (mechanism of action)?

Tecentriq Hybreza is a type of medicine known as immunotherapy. It turns on your body’s own immune system so it can fight against cancer cells that have a specific receptor called programmed cell death protein 1 (PD-1). Tecentriq Hybreza allows your immune system to find these cancer cells and kill them to slow or stop tumors from growing. Tecentriq Hybreza also contains hyaluronidase. The hyaluronidase helps allow the medicine to reach the cells when it is given as an injection under the skin.

How is Tecentriq Hybreza supplied (dosage forms)?

Brands and other names

  • Tecentriq Hybreza

Tecentriq Hybreza is available as an injectable form that is given by a health care provider.

How should I store Tecentriq Hybreza?

Tecentriq Hybreza is usually given by a health care provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Tecentriq Hybreza?

The most common side effects of Tecentriq Hybreza are listed below. Tell your health care provider if you have any of these side effects that bother you. 

  • Tiredness
  • Cough
  • Loss of appetite
  • Shortness of breath
  • Muscle and bone pain
  • Rash
  • Headache
  • Nausea and vomiting
  • High blood pressure
  • Constipation
  • Dizziness
  • Bleeding
  • Diarrhea
  • Trouble sleeping
  • Stomach pain
  • Low thyroid levels
  • Fever
  • Anxiety
  • Abnormal or skipping heartbeat

There may be other side effects of Tecentriq Hybreza that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 888-249-4918.

What are the serious side effects of Tecentriq Hybreza?

While less common, the most serious side effects of Tecentriq Hybreza are described below, along with what to do if they happen.

Severe Allergic Reactions. Tecentriq Hybreza may cause allergic reactions, which can be serious. Get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Immune System Reactions. Tecentriq Hybreza may cause your immune system to attack healthy tissues or organs, causing inflammation. When tissues or organs become inflamed, they may not work as well as they should. These side effects of immunotherapy can lead to serious or even life-threatening problems. You may be able to prevent these problems from getting more serious if you get medical help right away. Keep all appointments to check your blood work. Tell your health care provider right away if you have any of the following signs or symptoms even if you are no longer taking this medicine. 

  • Inflamed lungs (pneumonitis): Chest pain, shortness of breath, or new or worsening cough
  • Inflamed intestines (colitis): Severe stomach pain, diarrhea, blood or mucus in your stool or black, tarry stools
  • Inflamed liver (hepatitis): Severe nausea or vomiting, stomach pain on your right side, yellowish eyes or skin, dark urine (pee), or easy bleeding or bruising
  • Inflamed hormone glands (adrenal insufficiency, thyroiditis, type 1 diabetes): Headache, fast or irregular heartbeat, sweating, tiredness, weight gain or loss, hair loss, changes in mood or behavior, peeing more than usual, feeling cold
  • Inflamed kidneys (nephritis): Peeing less than usual, bloody urine, or swelling in your ankles
  • Skin inflammation (dermatitis): Skin rash, itching, blistering, or peeling or painful sores in your mouth, nose, throat, or genitals
  • Heart or blood vessel inflammation: Chest pain, fast or irregular heartbeat
  • Inflamed nerves: Weakness, numbness, or tingling in your arms or legs
  • Inflamed muscles or joints: Pain, swelling, or stiffness in your muscles or joints
  • Inflamed eye (uveitis): Blurred or double vision, eye pain or redness, sensitivity to light, vision loss
  • Inflamed pancreas (pancreatitis): Severe stomach pain, nausea, vomiting

Infusion Reactions. Tecentriq Hybreza can cause reactions that can be serious when it is given to you. Your infusion may need to be slowed or stopped if you have these reactions. These may be severe and even life-threatening. Tell your health care provider right away if you have any of the following symptoms when you get your infusion.

  • Itching or rash
  • Fever, chills, or shaking
  • Dizziness or feeling faint
  • Redness of your face and neck
  • Trouble breathing or wheezing
  • Back or neck pain

Warnings & Precautions

Who should not use Tecentriq Hybreza?

Allergies to Ingredients. People who are allergic to any of the following should not use Tecentriq Hybreza.

  • Tecentriq Hybreza
  • Atezolizumab
  • Hyaluronidase
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Tecentriq Hybreza.

What should I know about Tecentriq Hybreza before using it?

Tecenriq Hybreza is usually given by a health care provider in a hospital or clinic.

Your health care provider will do regular blood work while you are using Tecentriq Hybreza. It is important to attend all appointments, so your health care provider can make sure it is safe for you to use Tecentriq Hybreza. If you miss any appointments, reschedule with your health care provider right away.

Tecentriq Hybreza may cause fertility problems in people who are able to get pregnant. Talk with your health care provider if this is a concern for you. 

What should I tell my healthcare provider before using Tecentriq Hybreza?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Tecentriq Hybreza is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following. 

Pregnancy. Tecentriq Hybreza may cause harm to an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant. You must not be pregnant before starting Tecentriq Hybreza. If you can become pregnant, use effective birth control while using Tecentriq Hybreza and for at least five months after your last dose.

Breastfeeding. It is not known if Tecentriq Hybreza passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. You should not breastfeed while using Tecentriq Hybreza and for at least five months after your last dose. 

How can I get more information about Tecentriq Hybreza?

For more information about Tecentriq Hybreza, you can visit the drugmaker’s website at www.tecentriq.com/hybreza or call them at 877-436-3683.

Interactions

Does Tecentriq Hybreza interact with other medicines (drug interactions)?

There are no known interactions between Tecentriq Hybreza and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Tecentriq Hybreza?

If you or someone else has used too much Tecentriq Hybreza, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Tecentriq Hybreza?

Tecentriq Hybreza is usually given by a health care provider in a hospital or clinic. Your health care provider will make sure you are receiving Tecentriq Hybreza as scheduled. 

If you miss an appointment to get your Tecentriq Hybreza dose, call to make another appointment as soon as possible.