7 mins read

Overview: Revuforj is used to treat a certain type of acute leukemia. Do not start or stop any medicine without first talking with your health care provider or pharmacist. Common side effects include bleeding, nausea, muscle pain, infection, and tiredness. Call your health care provider right away if you get a fever, shortness of breath, cough, swelling of the arms or legs, reduced need to pee, dizziness, or changes in your heartbeat. 

Uses

What is Revuforj used for?

Revuforj (revumenib) is commonly used to treat certain people with a type of acute leukemia.

Revuforj may also be used for other conditions as determined by your health care provider.

How does Revuforj work (mechanism of action)?

Some people with acute leukemia have a genetic change, called a lysine methyltransferase 2A (KMT2A) translocation. These people make KMT2A proteins that bind to another protein called menin. This protein interaction drives the production of acute leukemia cells. Revuforj is called a menin inhibitor. The medicine blocks the protein interaction and allows for the development of normal blood cells.

How is Revuforj supplied (dosage forms)?

Brands and other names

  • Revuforj

Dosage forms and strengths

  • 25 mg, 110 mg, 160 mg oral tablets

How should I store Revuforj?

Revuforj should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Keep the medicine in its original container.

Side Effects

What are the most common side effects of Revuforj?

The most common side effects of Revuforj are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Bleeding
  • Nausea and vomiting
  • Muscle or joint pain
  • Infection
  • Changes in liver function tests
  • Febrile neutropenia
  • Diarrhea or constipation
  • Differentiation syndrome (see below)
  • Heart rhythm changes (see below)
  • Loss of appetite
  • Fluid retention
  • Tiredness

There may be other side effects of Revuforj that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Revuforj?

While less common, the most serious side effects of Revuforj are described below, along with what to do if they happen.

Severe Allergic Reactions. Revuforj may cause allergic reactions, which can be serious. Stop taking Revuforj and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives, which can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Differentiation Syndrome. Revuforj can cause a serious side effect called differentiation syndrome, which is a reaction caused by the rapid release of immune substances from cancer cells affected by Revuforj. This reaction has happened as soon as three days and up to 41 days after starting Revuforj. Differentiation syndrome is serious and can lead to organ damage or even death, if not treated early. Call your health care provider right away if you have any of the following symptoms of differentiation syndrome.

  • Fever
  • Cough or shortness of breath
  • Rash
  • Severe headache
  • Confusion
  • Dizziness or lightheadedness
  • Fast weight gain
  • Swelling of the arms, legs, neck, groin, or underarm area
  • Reduced need to pee

Heart Rhythm Changes. Revuforj may cause a rare, dangerous heart rhythm problem called QT prolongation and torsade de pointes. Some people have a higher risk of this, including people who are older, have other people in their family who have had these conditions, have low potassium or magnesium levels, or take medicines that can prolong the QT interval. Tell your health care provider right away if you faint or have changes in your heart rate or rhythm, such as a fast or skipping heartbeat.

Warnings & Precautions

Who should not use Revuforj?

Allergies to Ingredients. People who are allergic to any of the following should not take Revuforj.

  • Revuforj
  • Revumenib
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Revuforj.

What should I know about Revuforj before using it?

Do not take Revuforj unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Revuforj with other people, even if they have the same condition as you. It may harm them.

Keep Revuforj out of the reach of children.

Revuforj tablets come in different strengths, and each strength is in a different color. You may be prescribed more than one tablet strength of Revuforj to equal your dose. Do not change your dose or stop taking Revuforj unless your health care provider tells you to. Talk to your health care provider if you have any questions about how to take Revuforj.

Swallow Revuforj tablets whole. Do not cut or chew the tablets. If you are unable to swallow tablets, Revuforj tablets may be crushed, mixed in water, and taken within two hours of mixing. Follow your health care provider’s instructions if you will be crushing Revuforj tablets.

People who are 65 or older can be at greater risk for some side effects from Revuforj. Talk to your health care provider about your risks if you are in this age group.

Females who can become pregnant should use effective birth control during treatment with Revuforj and for four months after the last dose. If you can get your partner pregnant, use effective birth control during treatment with Revuforj and for four months after the last dose. Talk to your health care provider if you have any questions about birth control options during treatment with Revuforj.

Keep all appointments to have your blood checked. Your health care provider may need to stop Revuforj if you have an electrolyte imbalance, low white blood cell counts (neutropenia), or low platelet levels (thrombocytopenia). 

Revuforj may make it hard for you to get pregnant or get your partner pregnant. If you have concerns, talk to your health care provider.

What should I tell my health care provider before using Revuforj?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Revuforj is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • Heart problems, including heart failure, QT prolongation, or long QT syndrome
  • Low potassium levels (hypokalemia) or magnesium levels (hypomagnesemia)

Other Medicines and Supplements. Revuforj may interact with other medicines and supplements. Before taking Revuforj, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Revuforj may cause harm to a fetus. Your health care provider will have you take a pregnancy test within one week of starting Revuforj. Tell your health care provider if you are pregnant or plan to become pregnant. 

Breastfeeding. It is not known if Revuforj passes into breast milk. Do not take Revuforj while you are breastfeeding and for one week after the last dose. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Revuforj?

For more information about Revuforj, you can visit the drugmaker’s website at www.revuforj.com or call them at 888-539-3738.

Interactions

Does Revuforj interact with foods or drinks?

Revuforj should be taken on an empty stomach or with a low-fat meal containing approximately 400 calories and 25% or less fat.

There are no known interactions between Revuforj and alcohol, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.

Does Revuforj interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Revuforj.

  • Itraconazole (Sporanox, Tolsura), posaconazole (Noxafil), or voriconazole (Vfend), which are medicines used to treat fungal infections
  • Cobicistat (Tybost), which is a medicine used to treat HIV
  • Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis
  • St. John’s wort, which is a supplement that may be used to treat depression
  • Medicines that can cause QT prolongation, which is a potentially dangerous heart rhythm problem

Many other medicines may alter the blood levels of Revuforj and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Revuforj. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Revuforj?

If you or someone else has used too much Revuforj, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Revuforj?

If you miss a dose, take it as soon as you remember and at least 12 hours before your next dose. Do not take two doses within 12 hours. Return to your normal dosing schedule the next day.