Uses
Side Effects
Warnings & Precautions
Interactions
Overdose/Missed Dose
Reviews Uses
What is Voranigo used for?
Voranigo (vorasidenib) is commonly used to treat astrocytomas or oligodendrogliomas (certain types of brain tumors) after surgery. Your healthcare provider will do a blood test to see if you should take Voranigo.
Voranigo may also be used for other conditions as determined by your healthcare provider.
How does Voranigo work (mechanism of action)?
Voranigo binds to two proteins in the brain tumor cells. This prevents the activity of these proteins, which reduces the growth of the brain tumors.
How is Voranigo supplied (dosage forms)?
Voranigo is available in the following dosage forms that are taken by mouth.
- 10 mg oral tablets
- 40 mg oral tablets
How should I store Voranigo?
Voranigo should be stored in the original bottle, at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Voranigo includes canisters (desiccant) inside the bottle to keep the tablets dry. The canisters should not be swallowed or taken out of the bottle.
Side Effects
What are the most common side effects of Voranigo?
The most common side effects of Voranigo are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Low energy level or feeling tired
- Headache
- COVID-19
- Muscle pain or stiffness
- Diarrhea
- Nausea
- Seizures
- Liver damage (see below)
There may be other side effects of Voranigo that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Voranigo?
While less common, the most serious side effects of Voranigo are described below, along with what to do if they happen.
Severe Allergic Reactions. Voranigo may cause allergic reactions, which can be serious. Stop taking Voranigo and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking Voranigo. It is important that you keep all appointments, including blood work appointments, before you start taking Voranigo and during treatment. This will help your healthcare provider check the health of your liver. Call your healthcare provider right away if you have any of the following symptoms of liver damage.
Warnings & Precautions
Who should not use Voranigo?
Allergies to Ingredients. People who are allergic to any of the following should not take Voranigo.
- Voranigo
- Vorasidenib
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Voranigo.
What should I know about Voranigo before using it?
Do not take Voranigo unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Voranigo with other people, even if they have the same condition as you. It may harm them.
Keep Voranigo out of the reach of children.
Do not chew, cut, or crush Voranigo. The tablets should be swallowed whole with water.
You should take your dose of Voranigo around the same time each day.
If you vomit after taking a dose of Voranigo, you do not need to take a replacement dose. Just take your next dose as you normally would.
Do not stop taking Voranigo or change your Voranigo dose without your healthcare provider telling you to do so.
It is important that you keep all of your healthcare appointments while you are taking Voranigo, including lab appointments. These lab tests help your healthcare provider know if you need to stop or change your dose of Voranigo.
If it is possible for you to get pregnant, your healthcare provider will check to see if you are pregnant before you start taking Voranigo. If you use a birth control option that uses hormones, you will need to use a nonhormonal backup method during treatment and for 3 months after stopping Voranigo. Voranigo may make hormonal birth control not work as well. Nonhormonal birth control options include condoms and copper intrauterine devices (IUDs).
If you are sexually active with someone who can get pregnant, you should use an effective birth control option during treatment and for 3 months after stopping Voranigo. If your partner gets pregnant or thinks they are pregnant while you are taking Voranigo, tell your healthcare provider right away.
Voranigo may impair your fertility (make it difficult for you or your sexual partner to get pregnant). It is not known if this impairment of fertility goes away over time.
What should I tell my healthcare provider before using Voranigo?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking. This will help them determine if Voranigo is right for you.
In particular, make sure that you discuss any of the following.
Other Medicines and Supplements. Voranigo may interact with other medicines and supplements. Before taking Voranigo, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking. See the Interactions section for more details.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Liver problems
- Kidney problems, including if you are on dialysis
- Currently smoking tobacco
Pregnancy. Voranigo may harm your unborn baby. Tell your healthcare provider right away if you are or plan to become pregnant. If you become pregnant or think you are pregnant while you are taking Voranigo, tell your healthcare provider right away.
If you or your partner can become pregnant, use effective birth control while you are taking Voranigo and for 3 months after your last dose. Talk to your healthcare provider about your birth control options.
Breastfeeding. It is not known if Voranigo passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop Voranigo. You should not breastfeed while taking Voranigo or for 2 months after your last dose.
How can I get more information about Voranigo?
For more information about Voranigo, you can visit the manufacturer’s website at www.voranigo.com or call them at 800-813-5905.
Interactions
Does Voranigo interact with foods or drinks?
There are no known interactions between Voranigo and foods or drinks.
It is unknown if drinking alcohol will affect Voranigo.
Does Voranigo interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking.
In particular, make sure that you discuss if you are using any method of birth control that has hormones in it before taking Voranigo.
Many other medicines may alter the blood levels of Voranigo, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Voranigo. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally take too much Voranigo?
If you or someone else has taken too much Voranigo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Voranigo?
If you miss a dose and it is less than 6 hours from when you should have taken your dose, take the missed dose right away. If you miss a dose and it is more than 6 hours from when you should have taken your dose, skip the missed dose and take your next dose when you normally would.