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Overview: Ryoncil slows your immune response to treat acute graft versus host disease. Common side effects include infections, fever, and stomach pain. Tell your healthcare provider about any allergies you have, including allergies to meats, such as pig or cow. Notify your healthcare provider right away if you have fever, rash, hives, or breathing problems. Ryoncil is given as an infusion into your vein (IV) by your healthcare provider.

Uses

What is Ryoncil used for?

Ryoncil (remestemcel-L-rknd) is commonly used to treat certain people with acute graft versus host disease (aGVHD). This can happen after certain types of blood cell transplants. The transplanted blood cells treat your body cells like they do not belong, and they attack your normal cells. Many types of cells can be affected, including skin, gut, liver, or lungs.

Ryoncil may also be used for other conditions as determined by your healthcare provider.

How does Ryoncil work (mechanism of action)?

Ryoncil contains human mesenchymal stromal cells (MSCs). These cells may help slow your immune system down to stop the attack on your normal cells. 

How is Ryoncil supplied (dosage forms)?

Brands and other names

  • Ryoncil

Dosage forms and strengths

Ryoncil is available in an injectable form that is given by a healthcare provider.

How should I store Ryoncil?

Ryoncil is usually given by a healthcare provider in a hospital or clinic. You will not store it at home.

Side Effects

What are the most common side effects of Ryoncil?

The most common side effects of Ryoncil are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Infections
  • Fever
  • Bleeding
  • Fluid retention 
  • Stomach pain
  • High blood pressure

There may be other side effects of Ryoncil that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Ryoncil?

While less common, the most serious side effects of Ryoncil are described below, along with what to do if they happen.

Severe Allergic or Infusion Reactions. Ryoncil may cause infusion or allergic reactions, which can be serious. Tell your healthcare provider right away if you have any of the following symptoms when you get your infusion. Your infusion may need to be stopped.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infections. Ryoncil is made from human cells. Even though the cells are tested for infections, it is still possible for you to get an infection from Ryoncil. Some of these can be serious infections. Tell your healthcare provider about any new symptoms that you may get. 

Abnormal Tissue Growth. The human cells used to make Ryoncil can cause growth of cartilage, bone, or fat cells where they do not normally grow. Keep all scheduled appointments while using Ryoncil. Tell your healthcare provider about any new symptoms that you may get. 

Warnings & Precautions

Who should not use Ryoncil?

Allergies to Ingredients. People who are allergic to any of the following should not use Ryoncil.

  • Ryoncil
  • Remestemcel-L-rknd
  • Dimethyl sulfoxide (DMSO)
  • Porcine protein (protein from pigs)
  • Bovine protein (protein from cow-like animals, including ox, cow, buffalo, bison, and others)
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Ryoncil.

What should I know about Ryoncil before using it?

Ryoncil is usually given by a healthcare provider. You will likely receive other medicines, such as an antihistamine and corticosteroid, before Ryoncil to reduce your risk of infusion or allergic reactions. See the Side Effects section for more details.

What should I tell my healthcare provider before using Ryoncil?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Ryoncil is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Ryoncil could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Ryoncil passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Ryoncil while breastfeeding.

How can I get more information about Ryoncil?

For more information about Ryoncil, you can visit the manufacturer’s website at www.mesoblast.com or call them at 844-889-MESO (844-889-6376).

Interactions

Does Ryoncil interact with foods or drinks?

There are no known interactions between Ryoncil and foods or drinks.

It is unknown if drinking alcohol will affect Ryoncil.

Does Ryoncil interact with other medicines (drug interactions)?

There are no known interactions between Ryoncil and other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Ryoncil?

If you or someone else has used too much Ryoncil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Ryoncil?

Ryoncil is usually given by a healthcare provider in a hospital. Your healthcare provider will make sure you are receiving Ryoncil as scheduled.

If you miss an appointment to get your Ryoncil dose, call to make another appointment as soon as possible.