Ensacove (ensartinib) - Uses, Side Effects, and More

What are the most common side effects of Ensacove?

The most common side effects of Ensacove are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

• Rash, itching
• Muscle or bone pain
• Constipation
• Cough
• Nausea, vomiting
• Fluid retention, including skin swelling
• Tiredness
• Fever
• Increased liver function test results (ALT, bilirubin, and GGT)
• Increased amylase
• Decreased white blood cell levels
• Electrolyte changes (phosphate, magnesium, sodium, and potassium)
• Decreased protein (hemoglobin) in red blood cells

There may be other side effects of Ensacove that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Ensacove?

While less common, the most serious side effects of Ensacove are described below, along with what to do if they happen.

Severe Allergic Reactions. Ensacove may cause allergic reactions, including a specific type of allergic reaction called DRESS. DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms. It is also sometimes called multi-organ hypersensitivity. This is a reaction that can affect multiple parts of the body including your liver, kidneys, and heart. Stop taking the medicine and get help right away if you have any of the following symptoms of a serious allergic reaction.

• Breathing problems or wheezing
• Racing heart
• Itching, skin rash, or pale red bumps on the skin called hives
• Fever or general ill feeling
• Swollen lymph nodes
• Swelling of the face, lips, mouth, tongue, or throat
• Shortness of breath, trouble swallowing, or throat tightness
• Swelling in your feet, ankles, or legs
• Nausea or vomiting
• Dizziness, feeling lightheaded, or fainting
• Stomach cramps
• Joint pain
• Dark-colored pee
• Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Sensitivity to Sunlight. Your skin may be very sensitive to light from the sun and devices that give off similar light, such as sunlamps and tanning beds, while you are taking Ensacove. This is called photosensitivity. Use sunscreen (including on your lips) and wear a hat and clothes that cover your skin if you need to be in the sunlight while taking Ensacove and for one week after your last dose. Exposure to this kind of light, even for a short time, can cause your skin to be severely sunburned, blistered, or swollen. Tell your healthcare provider right away if any of these happen.

Lung Inflammation. Ensacove can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. Get emergency help if you have trouble breathing. You may also have a cough, fever, or chest pain. 

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking Ensacove. Keep all healthcare appointments, including those for lab work, while you are taking Ensacove. Call your healthcare provider right away if you have any of the following symptoms of liver damage.

• Nausea or vomiting
• Stomach or belly pain, especially on the right side
• Easy bleeding or bruising
• Fever
• Weakness or unusual tiredness
• Itching
• Loss of appetite
• Light-colored poop
• Dark-colored urine (pee)
• Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Heart Rate Changes. Ensacove can make your heart beat slower than normal (bradycardia). Call your healthcare provider right away if you feel lightheaded, dizzy, or if you faint.

High Blood Sugar. Ensacove may increase your blood sugar levels. Talk to your healthcare provider about how to maintain healthy blood sugar levels. Keep all appointments with your healthcare provider to check your blood work. Follow any instructions from your healthcare provider about checking your blood sugar levels at home. Call your healthcare provider if you have the following symptoms of high blood sugar.

• Thirsty more than usual
• Peeing more than usual
• Increase in hunger
• Tiredness or tiredness
• Feeling sick to your stomach
• Confusion
• Your breath smelling fruity

Vision Problems. Ensacove may increase your risk for vision problems. Tell your healthcare provider if you have any new or worsening vision problems or any of the following symptoms while you are taking Ensacove.

• Double vision
• Vision changes, such as blurry vision or sensitivity to light
• See flashes of light or new or an increased number of floaters

Muscle Problems. Ensacove can cause muscle problems, including muscle damage. Keep all appointments for blood work. Your healthcare provider may check your creatine phosphokinase (CPK) levels. Tell your healthcare provider if you have any unexplained muscle pain, weakness, tenderness, or muscle pain that does not go away.

Increased Uric Acid. Ensacove can increase your uric acid blood levels (hyperuricemia). You may not have any symptoms with high uric acid levels, but it can increase your risk for gout and kidney stones. Your healthcare provider may give you medicine to lower your uric acid levels if they get too high. Tell your healthcare provider if you notice any of the following symptoms of high uric acid levels.

• Painful joints that are red, swollen, or warm to the touch, especially one of your big toes
• Pink or brown pee
• Stomach or side pain
• Nausea or vomiting