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Overview: Tryngolza is used to lower triglycerides (fat in your blood) in certain people with very high triglyceride levels. Common side effects include redness or pain where you inject it and joint pain. Tryngolza is an injection given under your skin by you, your caregiver, or your healthcare provider. It is important to follow a low-fat diet while using Tryngolza.

Uses

What is Tryngolza used for?

Tryngolza (olezarsen) is commonly used to lower triglyceride levels (fat in your blood) in people with familial chylomicronemia syndrome (FCS), which is a genetic condition where your body has trouble breaking down fats.

Tryngolza may also be used for other conditions as determined by your healthcare provider.

How does Tryngolza work (mechanism of action)?

People who have familial chylomicronemia syndrome (FCS) have very high levels of triglycerides. Tryngolza works by lowering the amount of a protein called apolipoprotein C-III (apoC-III). This protein prevents the breakdown of fats in your blood. Tryngolza lowers apoC-III levels to help your body break down fat and lower triglyceride levels. 

How is Tryngolza supplied (dosage forms)?

Brands and other names

  • Tryngolza

Dosage forms and strengths

  • 80 mg/0.8 mL autoinjector

How should I store Tryngolza?

Store Tryngolza in the original carton in the refrigerator between 36 F and 46 F (2 C to 8 C). Once removed from the refrigerator, the medicine can be stored in the carton at room temperature, between 59 F and 86 F (15 C to 30 C) for up to six weeks. Throw any unused Tryngolza away after six weeks. Do not freeze it or expose it to heat or light.

Side Effects

What are the most common side effects of Tryngolza?

The most common side effects of Tryngolza are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Joint pain or stiffness
  • Low platelet levels
  • Redness or pain where you inject it

There may be other side effects of Tryngolza that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Tryngolza?

While less common, the most serious side effects of Tryngolza are described below, along with what to do if they happen.

Severe Allergic Reactions. Tryngolza may cause allergic reactions, which can be serious. Stop using Tryngolza and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Tryngolza?

Allergies to Ingredients. People who are allergic to any of the following should not use Tryngolza.

  • Tryngolza
  • Olezarsen
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Tryngolza.

What should I know about Tryngolza before using it?

Do not use Tryngolza unless it has been prescribed to you by a healthcare provider. Use it as prescribed. Read and follow the “Instructions for Use” that come with Tryngolza. This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Tryngolza. If you have any questions, talk to your healthcare provider. 

Do not share Tryngolza with other people, even if they have the same condition as you. It may harm them.

Keep Tryngolza out of the reach of children. Since this medicine should be kept in a refrigerator before using it, take special precautions to keep it away from children who also use the refrigerator.

You should follow a low-fat diet (less than 20 grams of fat per day) while using Tryngolza. Talk to your healthcare provider about ways to do this and foods to limit or avoid. 

What should I tell my healthcare provider before using Tryngolza?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Tryngolza is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Tryngolza could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.

Breastfeeding. It is not known if Tryngolza passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Tryngolza while breastfeeding.

How can I get more information about Tryngolza?

For more information about Tryngolza, you can visit the manufacturer’s website at www.tryngolza.com or call them at 833-644-6647.

Interactions

Does Tryngolza interact with foods or drinks?

There are no known interactions between Tryngolza and foods or drinks.

It is unknown if drinking alcohol will affect Tryngolza. However, alcohol may raise triglyceride levels. It is best to limit the amount of alcohol that you drink.

Does Tryngolza interact with other medicines (drug interactions)?

There are no known interactions between Tryngolza and other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Tryngolza?

If you or someone else has used too much Tryngolza, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Tryngolza?

If you miss a dose, use it as soon as you remember. Use your next dose one month after using the missed dose and then continue using it once each month. Do not use double or extra doses.

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