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Overview: Andembry is used to prevent attacks caused by hereditary angioedema (HAE). The medicine works to stop inflammation and swelling in people with HAE by blocking a protein called activated Factor XII. Common side effects can include skin reactions at the injection site, stomach pain, and common cold symptoms. Make sure that you or a caregiver understands how to properly prepare and use Andembry. If you have any questions, talk to your health care provider.

Uses

What is Andembry used for?

Andembry (garadacimab-gxii) is commonly used to prevent attacks from a rare, inherited condition called hereditary angioedema (HAE). 

Learn more about preventing hereditary angioedema attacks with Andembry.

Andembry may also be used for other conditions as determined by your health care provider.

How does Andembry work (mechanism of action)?

Andembry is known as an activated Factor XII (FXIIa) inhibitor. Activated Factor XII is a protein that starts an inflammatory system that can lead to swelling. Andembry blocks this protein, which helps to stop the process that causes swelling attacks in people with hereditary angioedema. 

How is Andembry supplied (dosage forms)?

Brands and other names

  • Andembry

Dosage forms and strengths

  • 200 mg/1.2 mL solution in single-dose prefilled autoinjector or syringe

How should I store Andembry?

Andembry should be stored in a refrigerator between 36 F and 46 F (2 C and 8 C). Do not freeze and do not shake the medicine. Keep the components of the medicine in the original carton to protect from light.

Side Effects

What are the most common side effects of Andembry?

The most common side effects of Andembry are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Pain, itching, swelling, or redness near the injection site
  • Stomach pain
  • Infection in the nose or throat, sore throat, or common cold symptoms

There may be other side effects of Andembry that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Andembry?

While less common, the most serious side effects of Andembry are described below, along with what to do if they happen.

Severe Allergic Reactions. Andembry may cause allergic reactions, which can be serious. Stop using Andembry and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Andembry?

Allergies to Ingredients. People who are allergic to any of the following should not use Andembry.

  • Andembry
  • Garadacimab-gxii
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Andembry.

What should I know about Andembry before using it?

Do not use Andembry unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Andembry with other people, even if they have the same condition as you. It may harm them.

Keep Andembry out of the reach of children. Since this medicine should be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator. 

This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Andembry. Follow the “Instructions for Use” that comes with your medicine. If you have any questions, talk to your health care provider.

Andembry can be used  in the belly area (1 inch or 2 cm away from your belly button) or thigh. If a caregiver is injecting the medicine, the injection can also be given in the upper arm area. Change the site you will be injecting each time you use the medicine. Before using Andembry, remove the medicine from the refrigerator and let it sit at room temperature for at least 30 minutes. 

Andembry may interfere with certain laboratory tests. Tell all of your healthcare providers that you are using Andembry. 

Andembry is a medicine used on a regular basis to help prevent symptoms (swelling attacks), but it does not treat swelling attacks when they occur. If you are having a swelling attack, get medical help or use a different medicine that was prescribed by your health care provider to treat the attack.

What should I tell my health care provider before using Andembry?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Andembry is right for you.

In particular, make sure that you discuss any of the following.

Pregnancy. It is not known if or how Andembry could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Andembry passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Andembry?

For more information about Andembry, you can visit the drugmaker’s website at www.andembry.com or call them at 866-915-6158.

Interactions

Does Andembry interact with foods or drinks?

There are no known interactions between Adembry and foods or drinks.

It is unknown if drinking alcohol will affect Andembry.

Does Andembry interact with other medicines (drug interactions)?

There are no known interactions between Andembry and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Andembry?

If you or someone else has used too much Andembry, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Andembry?

If you miss a dose, use it as soon as you remember. Then, contact your health care provider for instructions on when to use the next dose. Do not use double or extra doses.

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