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Overview: Zegfrovy is a tablet that you swallow for certain people with a type of lung cancer called non-small cell lung cancer. Common side effects include nausea, diarrhea, reduced appetite, mouth sores, or feeling tired. Contact your health care provider right away if you have cough, fever, rash, itching, vomiting, severe diarrhea, or vision changes, such as blurry vision or sensitivity to light. Get emergency help if you have chest pain or trouble breathing.

Uses

What is Zegfrovy used for?

Zegfrovy (sunvozertinib) is commonly used for certain people with non-small cell lung cancer. 

Zegfrovy may also be used for other conditions as determined by your health care provider.

How does Zegfrovy work (mechanism of action)?

Epidermal growth factor receptor (EGFR) is a protein on the surface of cells that helps cells to grow and multiply. Zegfrovy is a type of medicine called a kinase inhibitor. It attaches to a certain type of mutant EGFR protein. This causes mutant EGFR to quit sending the signal to cells to grow and multiply. Thus, Zegfrovy may help treat a certain type of non-small cell lung cancer.

How is Zegfrovy supplied (dosage forms)?

Brands and other names

  • Zegfrovy

Dosage forms and strengths

  • 150 mg oral tablets
  • 200 mg oral tablets

How should I store Zegfrovy?

Zegfrovy should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Zegfrovy?

The most common side effects of Zegfrovy are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Stomach problems like nausea, vomiting, diarrhea, or stomach pain (see below)
  • Skin problems like rash or itching (see below)
  • Dry skin 
  • Reduced appetite
  • Mouth sores
  • Feeling very tired
  • Infections of the skin around your finger nails or toe nails
  • Constipation
  • Muscle or joint pain 
  • Kidney or bladder infections 
  • Weight loss

There may be other side effects of Zegfrovy that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Zegfrovy?

While less common, the most serious side effects of Zegfrovy are described below, along with what to do if they happen.

Severe Allergic Reactions. Zegfrovy may cause allergic reactions, which can be serious. Stop taking Zegfrovy and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Lung Inflammation. Zegfrovy can cause inflammation in your lungs, also called interstitial lung disease or pneumonitis. This can be serious or even life-threatening. Get emergency help if you have new or worsening breathing problems or trouble breathing. You may also have a cough, fever, or chest pain. 

Stomach Problems. Nausea, vomiting, and diarrhea are common with Zegfrovy. Sometimes these can be severe. Take Zegfrovy with food to reduce this risk. You may be given medicine to prevent or treat nausea, vomiting, or diarrhea. If you do, take it exactly as your health care provider tells you. Drink plenty of fluids to stay hydrated. Call your health care provider right away if you have any of the following.

  • Severe nausea, vomiting, or diarrhea
  • Nausea, vomiting, or diarrhea that does not go away
  • Nausea, vomiting, or diarrhea with weakness, dizziness, or fever

Skin Problems. Itching and a rash are common with Zegfrovy. Sometimes these can be severe. To reduce the risk of having a severe skin reaction, try to use alcohol-free creams or lotions while you are taking Zegfrovy. You should also try to avoid using products on your skin that can be irritating. Examples of things that can irritate your skin include products with retinol, retinoic acid, or benzoyl peroxide. Tell your health care provider if you have any of the following side effects.

  • A severe rash or itching
  • Itching or a rash that will not go away
  • Bumps or blisters on the skin that may look like acne

Eye Problems. Zegfrovy may cause eye problems, including dry eye, vision changes, trouble seeing, or inflammation of the cornea (keratitis). If you have any of these problems and wear contact lenses, take them out until you can see an eye health care provider. Do not put contact lenses back in until at least one week after your eye symptoms go away or for as long as your health care provider tells you to wait. Contact your health care provider right away if you have any of the following symptoms.

  • Eye redness, irritation, or pain
  • Swollen or itchy eyelids
  • Crust forming in the corner of your eyes or on your eyelids
  • Feeling like you have something in your eye
  • Eye dryness, watering, or discharge
  • Vision changes, such as blurry vision, vision loss, or sensitivity to light

Warnings & Precautions

Who should not use Zegfrovy?

Allergies to Ingredients. People who are allergic to any of the following should not take Zegfrovy.

  • Sunvozertinib
  • Zegfrovy
  • Any of the ingredients in the specific product

Your pharmacist can tell you all of the ingredients in Zegfrovy.

What should I know about Zegfrovy before using it?

Do not take Zegfrovy unless it has been prescribed to you by a health care provider. Take it as prescribed. Do not change your dose or stop taking Zegrovy without your health care provider telling you to do so. 

Do not share Zegfrovy with other people, even if they have the same condition as you. It may harm them.

Keep Zegfrovy out of the reach of children.

Try to take your Zegrovy dose around the same time each day. Do not cut, chew, dissolve, or break Zegfrovy tablets. They should be swallowed whole. If you have any questions, talk to your pharmacist. 

Zegfrovy may make it hard for you to get pregnant or get your partner pregnant. If you have concerns, talk to your health care provider.

Zegfrovy can cause harm to an unborn baby. See the Pregnancy section for more details. If you are able to get your partner pregnant, use an effective method of birth control while you are taking Zegfrovy and for two weeks after your last dose. If you have any concerns, talk to your health care provider. 

What should I tell my health care provider before using Zegfrovy?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Zegfrovy is right for you.

In particular, make sure that you discuss any of the following.

Eye or Vision Problems. Zegfrovy can cause eye problems. Tell your health care provider if you have or have a history of any eye problems or trouble seeing.

Other Medicines and Supplements. Zegfrovy may interact with other medicines and supplements. Before taking Zegfrovy, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Zegfrovy may cause harm to an unborn baby. Your health care provider may do a test to make sure you are not pregnant before you start taking it. You should use birth control that does not have hormones in it while you are taking Zegfrovy and for two weeks after your last dose. Talk to your health care provider about which method of birth control you should use. Tell your health care provider if you are pregnant or think you may be pregnant while you are taking Zegrovy.

Breastfeeding. It is not known if Zegfrovy passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should stop breastfeeding or stop Zegfrovy.

How can I get more information about Zegfrovy?

For more information about Zegfrovy, you can call the drugmaker at 855-482-0653.

Interactions

Does Zegfrovy interact with foods or drinks?

Take Zegfrovy with food. This may help prevent or reduce nausea, diarrhea, or stomach pain that this medicine may cause. 

It is unknown if drinking alcohol will affect Zegfrovy, but heavy drinking can slow your immune response and make it harder for your body to fight cancer. Also, the risk of tiredness may be increased if you drink alcohol while taking Zegfrovy.

Does Zegfrovy interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Zegfrovy.

  • A birth control pill, patch, vaginal ring, implant, injection, or intrauterine device (IUD) that contains hormones
  • Itraconazole (Sporanox, Tolsura), which is a medicine used for fungal infections
  • Carbamazepine (Carbatrol, Tegretol, and others), which is a medicine commonly used to treat seizures or nerve pain
  • Efavirenz (Sustiva) or any other medicine that has efavirenz in it, such as Symfi or Symfi Lo, which is a medicine used to treat HIV
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
  • Rosuvastatin (Crestor), which is a medicine to lower cholesterol

Many other medicines may alter the blood levels of Zegfrovy, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Zegfrovy. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Zegfrovy?

If you or someone else has used too much Zegfrovy, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Zegfrovy?

If you miss a dose, take it as soon as you remember, as long as it is within 12 hours of the missed dose. If it has been 12 hours or more since you should have taken your dose, skip the missed dose and only take the next dose. If you vomit after taking a dose, just take your next dose when you normally would. Do not take double or extra doses.