6 mins read

Overview: Anzupgo is used to treat a certain type of eczema that affects the hands and wrists. Side effects can include pain, tingling, redness, or itching where you apply the medicine. Call your health care provider right away if you get an infection or have any symptoms of an infection, such as a fever or cough. Protect yourself from the sun, and do not use tanning beds or sunlamps. Tell your health care provider if you get any skin changes.

Uses

What is Anzupgo used for?

Anzupgo (delgocitinib) is commonly used to treat chronic hand eczema (CHE), a type of eczema that affects the hands and wrists.

Learn more about Treating Chronic Hand Eczema With Anzupgo.

Anzupgo may also be used for other conditions as determined by your health care provider.

How does Anzupgo work (mechanism of action)?

Anzupgo works to block signaling from specific proteins in your immune system that cause inflammation. This can help lower symptoms from chronic hand eczema. 

How is Anzupgo supplied (dosage forms)?

Brands and other names

  • Anzupgo

Dosage forms and strengths

  • 2% topical cream 

How should I store Anzupgo?

Anzupgo should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Do not freeze.

Side Effects

What are the most common side effects of Anzupgo?

The most common side effects of Anzupgo are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Pain, itching, tingling, or redness where the medicine is applied
  • Skin infections caused by bacteria
  • Low white blood cell levels

There may be other side effects of Anzupgo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Anzupgo?

While less common, the most serious side effects of Anzupgo are described below, along with what to do if they happen.

Severe Allergic Reactions. Anzupgo may cause allergic reactions, which can be serious. Stop using Anzupgo and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Infections. Anzupgo can lower the ability of your immune system to fight infections, which can increase your risk of infections, including serious infections. These serious infections can include tuberculosis (TB), shingles (herpes zoster), and other infections caused by bacteria, fungi, or viruses. Anzupgo can also reactivate infections that can remain in the body after you recover from that infection. Before you start treatment with Anzupgo, tell your health care provider if you have ever had tuberculosis (TB), hepatitis B, or any other serious infections. Call your health care provider right away if you have an infection or any of the following symptoms.

  • Burning or stinging when you pee 
  • Coughing, or coughing up blood
  • Fever, sweats, chills, or muscle aches
  • Shortness of breath
  • Diarrhea or stomach pain
  • Weight loss
  • Warm, red, or painful sores on your body
  • Feeling very tired

Skin Cancer. Anzupgo can increase your risk of getting certain non-melanoma skin cancers. Limit the amount of time you spend in the sun and wear sunscreen and protective clothing if you are out in the sun. Do not use sunlamps and tanning beds. Keep all appointments with your health care provider to have your skin checked while using the medicine. Check your skin regularly and talk to your healthcare provider if you have any changes to your skin.

Warnings & Precautions

Who should not use Anzupgo?

Allergies to Ingredients. People who are allergic to any of the following should not use Anzupgo.

  • Anzupgo
  • Delgocitinib
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Anzupgo.

What should I know about Anzupgo before using it?

Do not use Anzupgo unless it has been prescribed to you by a health care provider. Use it as prescribed.

Do not share Anzupgo with other people, even if they have the same condition as you. It may harm them.

Keep Anzupgo out of the reach of children.

Anzupgo is applied onto the skin of your hands and wrists. Do not get Anzupgo in your eyes, mouth, vagina, or nose. If this happens, rinse the area well with water. 

Clean and dry the affected area before applying this medicine. If someone else applies Anzupgo to you, they should wash their hands after handling the medicine. 

People who are 50 years and older can be at greater risk of some side effects from Anzupgo. Talk to your health care provider about your risks if you are in this age group or if you have any risk factors for heart disease.

What should I tell my health care provider before using Anzupgo?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Anzupgo is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • An infection or being treated for one
  • An infection that does not go away or that keeps coming back
  • Tuberculosis (TB), or have been in close contact with someone who has TB
  • History of shingles, hepatitis B, or hepatitis C
  • Cancer
  • Rheumatoid arthritis

Other Medicines and Supplements. Anzupgo is not recommended to be taken with certain other medicines. If you take medicines that weaken your immune system or are in the same class as Anzupgo (known as Janus kinase (JAK) inhibitors), tell your health care provider before using Anzupgo. Examples of JAK inhibitors include ruxolitinib (Opzulera), abrocitinib (Cibinqo), upadacitinib (Rinvoq), baricitinib (Olumiant), tofacitinib (Xeljanz), deuruxolitinib (Leqselvi), and ritlecitinib (Litfulo).

Vaccines. Talk with your health care provider about any vaccines that you may need. You should not receive certain vaccines right before, while using, or right after using Anzupgo. Tell your health care provider about any vaccines you have recently received or have scheduled.

Pregnancy. It is not known if or how Anzupgo could affect pregnancy or harm an unborn baby. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Anzupgo passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. If you use Anzupgo while breastfeeding, do not touch your nipple or your breast right after using the medicine. Touching these areas may cause your baby to get exposed to Anzupgo. 

How can I get more information about Anzupgo?

For more information about Anzupgo, you can visit the drugmaker’s website at www.anzupgo.com or call them at 877-494-4536.

Interactions

Does Anzupgo interact with foods or drinks?

There are no known interactions between Anzupgo and foods or drinks.

It is unknown if drinking alcohol will affect Anzupgo.

Does Anzupgo interact with other medicines (drug interactions)?

There are no known interactions between Anzupgo and other medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Anzupgo?

If you or someone else has used too much Anzupgo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Anzupgo?

If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses. 

Look up another drug