6 mins read

Overview: Inluriyo is used to treat certain types of breast cancer. It works by binding to estrogen receptors and causing them to break down, which helps prevent the growth and survival of certain cancer cells. Common side effects may include muscle or joint pain, tiredness, diarrhea, nausea, constipation, and stomach pain. Keep all appointments, including for blood tests, while you are taking Inluriyo. Inluriyo comes as a tablet that is taken by mouth.

Uses

What is Inluriyo used for?

Inluriyo (imlunestrant) is commonly used to treat certain people with breast cancer. Your health care provider can do a test to see if your cancer can be treated with Inluriyo.

Inluriyo may also be used for other conditions as determined by your health care provider.

How does Inluriyo work (mechanism of action)?

Inluriyo is an estrogen receptor blocker (antagonist). It is also called a selective estrogen receptor degrader (SERD). Some breast cancers are estrogen receptor (ER)-positive, which means that the hormone estrogen makes the cancer grow. Inluriyo binds to estrogen receptors and causes them to break down. This helps prevent the growth and survival of these cancer cells.

How is Inluriyo supplied (dosage forms)?

Inluriyo is available as a 200 mg oral tablet.

How should I store Inluriyo?

Inluriyo should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Inluriyo?

The most common side effects of Inluriyo are listed below. Tell your health care provider if you have any of these side effects that bother you.

There may be other side effects of Inluriyo that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Inluriyo?

While less common, the most serious side effects of Inluriyo are described below, along with what to do if they happen.

Severe Allergic Reactions. Inluriyo may cause allergic reactions, which can be serious. Stop taking Inluriyo and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Inluriyo?

Allergies to Ingredients. People who are allergic to any of the following should not take Inluriyo.

  • Imlunestrant
  • Inluriyo
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Inluriyo.

What should I know about Inluriyo before using it?

Do not take Inluriyo unless it has been prescribed to you by a health care provider. Take it as prescribed.

Do not share Inluriyo with other people, even if they have the same condition as you. It may harm them.

Keep Inluriyo out of the reach of children.

Do not chew, cut, or crush Inluriyo. Swallow the tablets whole at about the same time each day.

If you throw up (vomit) after taking a dose, do not take a repeat dose. Take your next dose at the regular scheduled time.

Keep all appointments, including for blood tests, while you are taking Inluriyo. This helps your health care provider make sure the medicine is safe for you. Your health care provider may adjust your dose, pause, or stop the medicine if you have certain side effects.

If you can get a partner pregnant, you should use effective birth control while taking Inluriyo and for one week after your last dose. See the Pregnancy section for more details.

Inluriyo may make it hard for you to get pregnant or get your partner pregnant. If you have concerns, talk to your health care provider.

Your health care provider may have you take other medicines along with Inluriyo. Follow the instructions from your health care provider.

If you have any unused or expired Inluriyo, ask your pharmacist or another health care provider how to throw it away. If possible, bring it to a medicine take-back program. Do not flush it down the toilet.

What should I tell my health care provider before using Inluriyo?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Inluriyo is right for you.

In particular, make sure that you discuss any of the following.

Liver Problems. Tell your health care provider if you have liver problems before taking Inluriyo. Your dose may need to be adjusted.

Other Medicines and Supplements. Inluriyo may interact with other medicines and supplements. Before taking Inluriyo, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. Inluriyo can cause harm to a fetus. Your health care provider will likely do a test to make sure you are not pregnant before starting this medicine. If you can get pregnant, you should use effective birth control while taking Inluriyo and for one week after your last dose. Tell your health care provider right away if you are pregnant, think you might be pregnant, or plan to become pregnant.

Breastfeeding. Do not breastfeed while you are taking Inluriyo and for one week after your last dose. It is not known if Inluriyo passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed.

How can I get more information about Inluriyo?

For more information about Inluriyo, you can visit the drugmaker’s website at www.inluriyo.com or call them at 800-545-5979.

Interactions

Does Inluriyo interact with foods or drinks?

Inluriyo should be taken on an empty stomach, at least two hours before food or one hour after food.

It is unknown if drinking alcohol will affect Inluriyo, but heavy drinking can slow your immune response and make it harder for your body to fight cancer.

Does Inluriyo interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Inluriyo.

  • Itraconazole (Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), or voriconazole (Vfend), which are medicines used for fungal infections
  • Carbamazepine (Carbatrol, Tegretol, and others), which is a medicine commonly used to treat seizures or nerve pain
  • Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure

Many other medicines may alter the blood levels of Inluriyo, and vice versa. Tell your health care provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Inluriyo. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Inluriyo?

If you or someone else has used too much Inluriyo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Inluriyo?

If you miss a dose, take it as soon as you remember. If you have missed the dose by six hours or more, skip the missed dose and only take the next dose at your regular scheduled time. Do not take double or extra doses.