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Overview: Nicotine is used to help reduce withdrawal symptoms from quitting smoking. Common side effects vary based on the form of nicotine that you use. It is available in several forms, including a lozenge, gum, patch, and nasal spray. Make sure you understand how to use the product you have properly. This will improve your chances of quitting and limit side effects.

Uses

What is nicotine used for?

Nicotine is commonly used to help reduce withdrawal symptoms and cravings from stopping smoking.

Nicotine may also be used for other conditions as determined by your health care provider.

How does nicotine work (mechanism of action)?

Nicotine binds to nicotine receptors in your body and mimics the effects of smoking nicotine to help reduce cravings and withdrawal symptoms. It is also known as nicotine replacement therapy (NRT).

How is nicotine supplied (dosage forms)?

Brands and other names

  • Commit
  • Habitrol
  • NicoDerm
  • Nicorette
  • Nicotrol
  • Thrive

Dosage forms and strengths

  • 2 mg, 4 mg gum
  • 2 mg, 4 mg lozenge
  • 0.5 mg/spray nasal spray
  • 7 mg/24 hours, 14 mg/24 hours, 21 mg/24 hours transdermal patch

How should I store nicotine?

Nicotine should be stored at room temperature, between 68 F and 77 F (20 C and 25 C). Store in a cool, dry place. Protect from light.

Side Effects

What are the most common side effects of nicotine?

The most common side effects of nicotine are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Nausea
  • Headache
  • Skin irritation, unusual dreams, or sleep problems (patches)
  • Mouth or throat irritation, heartburn, hiccups, or coughing (gum or lozenges)
  • Nose irritation, runny nose, watery eyes, sneezing, or coughing (nasal spray)

There may be other side effects of nicotine that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of nicotine?

While less common, the most serious side effects of nicotine are described below, along with what to do if they happen.

Severe Allergic Reactions. Nicotine may cause allergic reactions, which can be serious. Stop using nicotine and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives, which can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Heart Effects. Nicotine may increase your risk of certain effects on the heart, such as a raised heart rate or blood pressure or an abnormal heart rhythm (arrhythmia). Stop using nicotine and contact your health care provider if you have an irregular heartbeat or a fluttering feeling in your chest (palpitations).

Too Much Nicotine. You may have symptoms of a nicotine overdose, especially if you smoke while using nicotine or use nicotine in a way other than recommended. Stop using nicotine and contact your health care provider if you have any of the following.

  • Severe headaches
  • Upset stomach, nausea, or vomiting
  • Diarrhea
  • Dizziness, weakness, or fainting
  • A fast heartbeat or a weak pulse
  • Confusion
  • Trouble hearing
  • Cold sweats or drooling

Warnings & Precautions

Who should not use nicotine?

Allergies to Ingredients. People who are allergic to any of the following should not use nicotine.

  • Commit
  • Habitrol
  • NicoDerm
  • Nicorette
  • Nicotine
  • Nicotrol
  • Thrive
  • Any of the ingredients in the specific product

Your pharmacist can tell you all of the ingredients in the specific nicotine products they stock.

What should I know about nicotine before using it?

There are multiple forms of nicotine available, and they are used in different ways. If nicotine was prescribed to you by a health care provider, use it as prescribed. If you are using over-the-counter (OTC) nicotine, read and follow the instructions that come with the product.

Do not share nicotine that was prescribed for you by a health care provider with other people, even if they have the same condition as you. It may harm them.

Make sure you understand how to use your nicotine product properly. Proper use can increase your chances of quitting smoking successfully and lower your risk of side effects. If you have any questions, talk to your health care provider.

For the best chances of success, nicotine should be used as part of a program to help you stop smoking. Talk to your pharmacist or other health care provider if you need help finding one.

Nicotine can be addictive, even when it is used to help you stop smoking. You may be more likely to become dependent on nicotine nasal spray than other forms of nicotine replacement therapy, such as nicotine gum, lozenges, or patches. Your chance of dependence may be higher if you use more nicotine than recommended or use it for longer than is recommended.

Keep nicotine out of the reach of children and pets. Even unused nicotine patches, chewed pieces of nicotine gum, and used nicotine nasal spray bottles may still have enough nicotine in them to harm a child or pet. Fold nicotine patches in half so the sticky sides are together and wrap used pieces of nicotine gum or lozenges in paper before throwing them away. Throw nicotine away in a place that children and pets are not able to get to. Ask your pharmacist or other health care provider if you are not sure how to throw away your nicotine product safely.

If you are using a nicotine patch and have trouble sleeping or vivid dreams, you can take the patch off before going to bed to see if that helps. If you have questions or concerns, talk to your health care provider.

If you are using a nicotine patch, stop using it and contact your health care provider if you have any of the following symptoms where you applied the patch.

  • Redness that lasts for four days or longer
  • Swelling
  • Rash

Do not cut the nicotine patch.

If you are using nicotine gum or lozenge, stop using it and contact your health care provider if you have any of the following.

  • Blisters in your mouth
  • Severe sore throat
  • Problems with your mouth, teeth, or jaw
  • An upset stomach that does not go away

Do not chew or swallow nicotine lozenges.

If you are using nicotine nasal spray and have nasal irritation, it usually goes away over time. If you are still having problems with nasal irritation after a week of regular use, contact your health care provider. If you have a runny or stuffy nose or are using certain nasal sprays (such as oxymetazoline) for these symptoms, it may affect how nicotine nasal spray works. Talk to your health care provider if you have concerns.

Use of nicotine nasal spray can lead to short-term symptoms such as sneezing or watery eyes. Wait five minutes after using it before driving. Be careful not to spray nicotine nasal spray into your eyes while using it.

What should I tell my health care provider before using nicotine?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if nicotine is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have or have had any of the following.

Low-Sodium (Salt) Diet. Talk with your health care provider if you follow a low-sodium diet. Some nicotine gums or lozenges may contain sodium.

Other Medicines and Supplements. Nicotine may interact with other medicines and supplements. Before using nicotine, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how nicotine could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant. Your health care provider will let you know if you should use nicotine while you are pregnant or trying to get pregnant.

Breastfeeding. Nicotine passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use nicotine while breastfeeding.

Interactions

Does nicotine interact with foods or drinks?

Gum and Lozenge. You should not eat or drink for 15 minutes before using nicotine gum or lozenge or while the gum or lozenge is in your mouth. Foods and drinks, especially acidic ones (such as coffee or soda), may make the gum or lozenge not work as well.

Patch and Nasal Spray. There are no known interactions between nicotine and foods or drinks.

It is unknown if drinking alcohol will affect nicotine.

Does nicotine interact with other medicines (drug interactions)?

Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before using nicotine.

  • Any other medicine to help you stop smoking
  • A medicine for depression
  • A medicine for asthma

When you quit smoking, it may affect the levels of other medicines in your body. This can happen with or without using nicotine. Make sure to tell your health care provider if you are quitting smoking. Some examples of medicines that might need changes to their doses if you quit smoking are listed below.

  • Theophylline (Elixophyllin, Theo-24), which is a medicine for asthma or certain other breathing problems 
  • Insulin, which is a medicine used to lower blood sugar in people with diabetes

This may not be a complete list of medicines that can interact with nicotine. Always check with your health care provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much nicotine?

If you or someone else has used too much nicotine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of nicotine?

If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only use the next dose. Do not use double or extra doses.