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Uses

What is methscopolamine used for?

Methscopolamine is commonly used to reduce burning, pain, and other symptoms of stomach ulcers. 

Methscopolamine may also be used for other conditions as determined by your healthcare provider.

How does methscopolamine work (mechanism of action)?

Methscopolamine blocks certain signals in the body to help reduce the amount of acid and other fluids your stomach produces. 

How is methscopolamine supplied (dosage forms)?

Brands and other names

  • Pamine
  • Pamine Forte

Dosage forms and strengths

  • 2.5 mg, 5 mg oral tablets

How should I store methscopolamine?

Methscopolamine should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of methscopolamine?

The most common side effects of methscopolamine are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Fast heartbeat
  • Confusion or nervousness
  • Drowsiness or dizziness
  • Headache 
  • Blurred vision or dilated pupils 
  • Nausea,vomiting, or constipation
  • Dry mouth or changes in taste
  • Trouble sleeping
  • Problems peeing
  • Problems getting or keeping an erection 

There may be other side effects of methscopolamine that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of methscopolamine?

While less common, the most serious side effects of methscopolamine are described below, along with what to do if they happen.

Severe Allergic Reactions. Methscopolamine may cause allergic reactions, which can be serious. Stop taking methscopolamine and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Body Temperature Regulation. Methscopolamine can affect your ability to regulate your body temperature. This could make you become very hot, especially in hot weather or after exercising a lot. You should drink water and avoid overheating and dehydration. Call your healthcare provider right away if you are severely ill and have the following symptoms.

  • Excessive or no sweating
  • Dry mouth
  • Feeling very hot
  • Feeling thirsty
  • Not able to pee

Blockage of the Gut. Some people taking methscopolamine may develop a blockage of the gut, especially if you have an ileostomy or colostomy (openings made in the belly to collect poop). Stop taking methscopolamine and call your healthcare provider right away if you have diarrhea. This can be an early sign that you have a blockage in your gut.

Warnings & Precautions

Who should not use methscopolamine?

Allergies to Ingredients. People who are allergic to any of the following should not take methscopolamine.

  • Methscopolamine
  • Pamine
  • Pamine Forte
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in the specific methscopolamine products they stock.

Glaucoma. Glaucoma is a condition that may lead to trouble seeing or blindness because of damage to the optic nerve in your eye. Methscopolamine can make this condition worse and should not be used if you have glaucoma.

Blockage of the Urinary Tract. Methscopolamine should not be used if you have a blockage in your urinary tract, also called obstructive uropathy. Methscopolamine can make this condition worse. 

Enlarged Prostate. Methscopolamine should not be used if you have an enlarged prostate, also called benign prostatic hyperplasia (BPH). Methscopolamine can make this condition worse.

Gut Blockage. Methscopolamine should not be used if you have a blockage of your gut (bowel obstruction). Methscopolamine can make this worse.

Slowed Gut Movement. Paralytic ileus is a type of ileus where your intestines are unable to move food through them. Methscopolamine can make this condition worse. 

Severe Ulcerative Colitis. Ulcerative colitis is an inflammatory bowel disease that can cause pain and sores in the lining of your large intestine. Methscopolamine can make this condition worse.

Toxic Megacolon. Toxic megacolon is a rare and serious condition that can cause your colon to swell, weaken, and stop working properly. Methscopolamine can make this condition worse. 

Myasthenia gravis. Myasthenia gravis is a condition that can cause muscle weakness. Methscopolamine can make this condition worse. It should not be used if you have a history of this condition.

What should I know about methscopolamine before using it?

Do not take methscopolamine unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Do not share methscopolamine with other people, even if they have the same condition as you. It may harm them.

Keep methscopolamine out of the reach of children.

Methscopolamine can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how methscopolamine affects you.

People who are 65 or older can be at greater risk for some side effects from methscopolamine. Talk to your healthcare provider about your risks if you are in this age group.

It is important to keep all of your healthcare appointments while you are taking methscopolamine, including lab appointments. These appointments help your healthcare provider know if the medicine is working or whether your condition is improving.

hat should I tell my healthcare provider before using methscopolamine?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if methscopolamine is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.

  • Nerve damage
  • Kidney or liver problems
  • Stomach or bowel problems
  • Thyroid problems
  • Heart problems or fast or abnormal heartbeats 
  • High blood pressure
  • Prostate problems

Other Medicines and Supplements. Methscopolamine may interact with other medicines and supplements. Before taking methscopolamine, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how methscopolamine could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take methscopolamine while you are pregnant or trying to get pregnant

Breastfeeding. It is not known if methscopolamine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop methscopolamine.

Interactions

Does methscopolamine interact with foods or drinks?

There are no known interactions between methscopolamine and foods or drinks.

It is unknown if drinking alcohol will affect methscopolamine. The risk of drowsiness and blurred vision may be increased if you drink alcohol while taking methscopolamine.

Does methscopolamine interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking methscopolamine.

  • An anticholinergic medicine, which includes antihistamines and medicines commonly used for overactive bladder, Parkinson’s disease, or stomach problems
  • A tricyclic antidepressant, such as amitriptyline, nortriptyline, or protriptyline, even if it is not used for depression
  • An antipsychotic, which is a medicine for certain mental health conditions
  • An antacid containing calcium, aluminum, magnesium, or iron
  • Any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety 

This may not be a complete list of medicines that can interact with methscopolamine. Always check with your healthcare provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much methscopolamine?

If you or someone else has used too much methscopolamine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of methscopolamine?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.