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Overview: Humate-P is used to prevent or treat bleeding in people with certain bleeding disorders. Allergic reactions are a common side effect. Get emergency help if you have chest pain, chest pressure, or trouble breathing.

Uses

What is Humate-P used for?

Humate-P (antihemophilic factor/von Willebrand factor complex) is commonly used for the following types of bleeding in people with hemophilia A or von Willebrand disease. 

  • To prevent or treat sudden bleeding episodes
  • To prevent or treat bleeding during or after surgery

Humate-P may also be used for other conditions as determined by your health care provider.

How does Humate-P work (mechanism of action)?

People who have hemophilia A or von Willebrand disease do not make enough of their own proteins called antihemophilic factor (factor VIII) or von Willebrand factor (VWF). Your body uses these proteins to form blood clots to stop bleeding. This medicine increases these protein levels and helps your body form blood clots to prevent or stop bleeding.

How is Humate-P supplied (dosage forms)?

Brands and other names

  • Humate-P

Dosage forms and strengths

  • 250 IU factor VIII (FVIII) single-dose vials
  • 500 IU factor VIII (FVIII) single-dose vials
  • 1,000 IU factor VIII (FVIII) single-dose vials

How should I store Humate-P?

Humate-P is usually given by a health care provider in a hospital or clinic. If you will store Humate-P at home, store it at room temperature, up to 77 F (25 C). Do not freeze.

Side Effects

What are the most common side effects of Humate-P?

The most common side effects of Humate-P are listed below. Tell your health care provider if you have any of these side effects that bother you.

  • Severe allergic reactions (see below)
  • Bleeding

There may be other side effects of Humate-P that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088 (800-332-1088). In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Humate-P?

While less common, the most serious side effects of Humate-P are described below, along with what to do if they happen.

Severe Allergic Reactions. Humate-P may cause allergic reactions, which can be serious. Stop using Humate-P and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching or skin rash
  • Bumps on the skin called hives that can be red, pink, white, or brown depending on your skin tone
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Risk of Infection. Humate-P is made from human blood and may carry germs, such as viruses, that can cause infections. The drugmaker takes steps to reduce the risk, such as screening donors and testing samples for infections. There is still a small chance you could get an infection. Tell your health care provider right away if you notice any of the following new symptoms.

  • Fever
  • Rash
  • Nausea, vomiting, or diarrhea
  • Weakness or general ill feeling
  • Yellowish eyes or skin
  • Joint pain
  • Loss of appetite

Blood Clots. Humate-P may cause blood clots in your arteries or veins and could cause a stroke, heart attack, or venous thromboembolism, including a blood clot in the lungs (pulmonary embolism) or deep venous thrombosis (DVT). You may be at a higher risk for blood clots if you have certain health conditions or take certain medicines. Stop using Humate-P and get emergency help if you have any of the following signs of blood clots. 

  • Chest pain or pressure
  • Fast or abnormal heartbeat
  • Trouble breathing
  • Pain in your back, jaw, throat, or arm
  • Sweating, upset stomach, vomiting, or dizziness
  • Sudden weakness on one side of your body
  • Sudden and severe headache
  • Slurred speech or trouble understanding speech
  • Pain, swelling, or tenderness in your arm or leg
  • Vision loss
  • Bulging eyes 
  • Double vision

Warnings & Precautions

Who should not use Humate-P?

Allergies to Ingredients. People who are allergic to any of the following should not use Humate-P.

  • Antihemophilic factor/von Willebrand factor complex
  • Humate-P
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Humate-P.

What should I know about Humate-P before using it?

Do not use Humate-P unless it has been prescribed to you by a health care provider. Use it as prescribed. This medicine is given into one of your veins. If you use Humate-P at home, make sure that you or a caregiver understands how to properly prepare and use it.

Do not share Humate-P with other people, even if they have the same condition as you. It may harm them.

Keep Humate-P out of the reach of children. If this medicine is kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.

If you are using Humate-P at home to treat a bleeding episode, call your health care provider or get medical care right away if your bleeding does not stop. 

Keep all of your appointments, including those for lab tests. Your health care provider needs test results to help you use this medicine safely.

Talk with your health care provider about any vaccines that you may need. Ask them if you might need hepatitis A and hepatitis B vaccines.

What should I tell my health care provider before using Humate-P?

Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if Humate-P is right for you.

In particular, make sure that you discuss any of the following.

Current and Past Health Conditions. Tell your health care provider if you have any of the following.

  • A history of blood clots
  • Diabetes
  • High blood pressure
  • High cholesterol levels
  • Smoke tobacco
  • Metabolic syndrome
  • Cancer
  • Age 65 years or older
  • Surgery
  • Have inhibitors or antibodies to factor VIII or von Willebrand factor
  • Blood group A, B, or AB

Pregnancy. It is not known if or how Humate-P could affect pregnancy or harm a fetus. Tell your health care provider if you are pregnant or plan to become pregnant.

Breastfeeding. It is not known if Humate-P passes into breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should use Humate-P while breastfeeding.

How can I get more information about Humate-P?

For more information about Humate-P, you can visit the drugmaker’s website at www.humate-p.com.

Interactions

Does Humate-P interact with foods or drinks?

There are no known interactions between Humate-P and foods or drinks.

It is unknown if drinking alcohol will affect Humate-P, but alcohol can increase your risk for bleeding. It is best to limit the amount of alcohol you drink.

Does Humate-P interact with other medicines (drug interactions)?

Humate-P may interact with certain medicines. Always tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Humate-P?

If you or someone else has used too much Humate-P, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Humate-P?

Humate-P is meant to be used only when needed. Use it as your health care provider recommends. Do not use double or extra doses.