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Overview: Cefdinir is an antibiotic used to treat certain infections caused by bacteria. It works by killing the bacteria that cause the infection. Common side effects include nausea, vomiting , or diarrhea. Serious side effects are much less common, but can include a type of diarrhea that is difficult to treat. Notify your healthcare provider right away if you develop watery or bloody diarrhea. Cefdinir comes as a capsule and liquid that you take by mouth.

Uses

What is cefdinir used for?

Cefdinir is an antibiotic that is commonly taken for the following infections caused by certain bacteria (bacterial infection).

Cefdinir may not be appropriate for some of the infections listed above, depending on which germs are causing the infection. Bacteria in some locations may have developed resistance to cefdinir, which will make it not work as well.

Cefdinir may also be used for other conditions as determined by your healthcare provider.

How does cefdinir work (mechanism of action)?

Cefdinir kills certain bacteria by preventing them from being able to create their cell wall.

How is cefdinir supplied (dosage forms)?

Dosage forms and strengths

  • 300 mg oral capsules
  • 125 mg/5 mL oral suspension
  • 250 mg/5 mL oral suspension

How should I store cefdinir?

Oral Capsules. Cefdinir capsules stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Cefdinir capsules should be protected from light. 

Oral Liquid. Cefdinir oral liquid should be stored at room temperature, 77 F (25 C). Throw away any unused liquid after ten days. 

Side Effects

What are the most common side effects of cefdinir?

The most common side effects of cefdinir are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Diarrhea
  • Vaginal yeast infections
  • Nausea or vomiting
  • Rash
  • Headache
  • Stomach pain
  • Vaginal pain

There may be other side effects of cefdinir that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of cefdinir?

While less common, the most serious side effects of cefdinir are described below, along with what to do if they happen.

Severe Allergic Reactions. Cefdinir may cause allergic reactions, which can be serious. Stop taking cefdinir and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Severe Skin Reactions. Cefdinir can cause severe skin reactions called Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) that can lead to death if not treated. If you develop a rash, stop cefdinir and call your healthcare provider right away. Get emergency help right away if you have any of the following symptoms of SJS or TEN.

  • Painful red or purple skin that looks burned and peels off
  • Flat red rash or blisters on your skin, mouth, nose, and genitals
  • Red, painful, watery eyes

Seizures. Some people who have taken cefdinir have reported having seizures. There are many different types of seizures and some of them are not easy to recognize. Stop taking cefdinir and call your healthcare provider if you have any of the following signs that a seizure is happening or could happen.

  • Muscle twitching, jerking, spasms, tremors, or other uncontrolled movements
  • Stiffening of your arms and legs
  • Feeling anxious, nervous, confused, or a sense of dread
  • Feeling dizzy or lightheaded
  • Falling or losing consciousness

Antibiotic-associated Diarrhea. An overgrowth of germs called Clostridioides difficile, or “C. diff,” can happen in your gut with many types of antibiotics, including cefdinir. This can cause a condition known as antibiotic-associated diarrhea and can happen even up to two months after stopping the antibiotic. Call your healthcare provider right away if you have any of the following symptoms of this condition.

  • Watery diarrhea
  • Diarrhea that does not go away
  • Blood in your stool (poop)
  • Severe stomach cramps
  • Fever that starts after you start or finish the medicine

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking cefdinir. Call your healthcare provider right away if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Kidney Damage. Kidney damage can happen when taking cefdinir. Call your healthcare provider right away if you have any of the following symptoms of kidney damage.

  • Reduced need to pee
  • Swelling in your feet, ankles, or legs
  • Weakness or unusual tiredness
  • Difficulty catching your breath or chest pain/pressure
  • Confusion
  • Nausea
  • Seizures

Blood Disorders. Cefdinir can cause blood disorders, such as agranulocytosis, aplastic anemia, hemolytic anemia, low platelet levels (thrombocytopenia), and low white blood cell levels (leukopenia or neutropenia). Stop taking cefdinir and get help right away if you have any of the following symptoms of blood disorders.

  • Fever, chills, or sweats
  • Sore throat
  • Cough or shortness of breath
  • Pale or yellowish skin
  • Easy bruising or bleeding
  • Frequent infection
  • Unusual weakness or tiredness
  • Dizziness, lightheadedness, or feeling like you are about to pass out
  • Headache
  • Fast or abnormal heartbeat
  • Mouth or throat sores
  • Swollen lymph nodes

Another Infection With Prolonged Use. Using cefdinir for a prolonged period of time may lead to an infection with other types of germs, such as fungi. Call your healthcare provider if your infection does not improve or gets worse.

Warnings & Precautions

Who should not use cefdinir?

Allergies to Ingredients. People who are allergic to any of the following should not take cefdinir.

  • Cefdinir
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in the specific cefdinir products they stock.

What should I know about cefdinir before using it?

Do not take cefdinir unless it has been prescribed to you by a healthcare provider. Take it as prescribed.

Cefdinir only treats certain infections caused by bacteria. Cefdinir will not work for viral infections, such as the common cold, influenza, or coronavirus. It also will not work for any other non-bacterial infections. Taking cefdinir or any other antibiotic when it is not needed (infections other than those caused by bacteria, or the lack of an infection in general) may cause the antibiotic to not work for bacterial infections in the future.

Do not share cefdinir with other people, even if they have the same condition as you. It may harm them.

Keep cefdinir out of the reach of children.

Use an accurate measuring device to measure your dose of cefdinir liquid. A household spoon is not an accurate measuring device and may cause you to take the wrong dose. Ask your pharmacist to recommend an appropriate measuring device. Shake cefdinir liquid well before measuring each dose.

If you take antacids or iron supplements, you should take cefdinir at least two hours before or after these things. 

What should I tell my healthcare provider before using cefdinir?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if cefdinir is right for you.

In particular, make sure that you discuss any of the following.

  • An allergy to penicillins and/or cephalosporins
  • Liver problems
  • Kidney problems
  • History of antibiotic-associated diarrhea

Other Medicines and Supplements. Cefdinir may interact with other medicines and supplements. Before taking cefdinir, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

Pregnancy. It is not known if or how cefdinir could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take cefdinir while you are pregnant or trying to get pregnant.

Breastfeeding. It is not known if cefdinir passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take cefdinir while breastfeeding.

Interactions

Does cefdinir interact with foods or drinks?

Consuming foods that are fortified with iron, such as iron-fortified breakfast cereal, may reduce the amount of cefdinir in your body. This may keep it from working.

It is unknown if drinking alcohol will affect cefdinir, but heavy drinking can slow your immune response and make it harder for your body to fight infection.

Does cefdinir interact with other medicines (drug interactions)?

Always tell your healthcare provider about any prescription or OTC medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking cefdinir.

  • An antacid or supplement containing calcium, aluminum, magnesium, or iron
  • Probenecid, which is a medicine commonly used for gout

This may not be a complete list of medicines that can interact with cefdinir. Always check with your healthcare provider.

Does interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much cefdinir?

If you or someone else has used too much cefdinir, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of cefdinir?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

It is important to complete your prescribed course of cefdinir, even if your symptoms get better or go away. This will reduce the risk that future infections are resistant to cefdinir or other similar medicines.