Alka-Seltzer Products for Cough, Cold, and Flu Symptoms

Medically Reviewed by Michelle Vermeulen, PharmD on April 08, 2025
8 min read

Alka-Seltzer products are used to treat coughs, colds, symptoms caused by the flu, and symptoms caused by allergies. Alka-Seltzer products may contain a variation of active ingredients. Click on an ingredient below if you need more information about it.

  • Pain reliever/fever reducer (acetaminophen, aspirin), which is used for fever and pain, including headaches, body aches, and sore throat
  • Decongestant (phenylephrine), which lowers swelling, inflammation, and congestion in your nose and sinuses, allowing you to breathe better
  • Antihistamine (chlorpheniramine, doxylamine), which can help with a runny nose, sneezing, itchy/watery eyes, and itching of the nose and throat
  • Cough suppressant (dextromethorphan), which reduces the urge to cough
  • Expectorant (guaifenesin), which loosens mucus and breaks up chest congestion

There are Alka-Seltzer products for adults and children as young as 6 years old.

Alka-Seltzer products that contain an antihistamine (chlorpheniramine, doxylamine) may cause you to feel drowsy. If you feel drowsy after taking Alka-Seltzer, do not drive or do other activities that require alertness or coordination until you know how an Alka-Seltzer product affects you. Taking certain medicines or drinking alcohol can increase your risk for drowsiness. Talk to your health care provider about any other medicines you take or if you drink alcohol.

Check the label on the Alka-Seltzer product you are planning on taking to make sure you are not allergic to any of the ingredients.

If you are taking Alka-Seltzer products for a sore throat and also develop a fever, headache, rash, nausea, or vomiting for more than two days, call your health care provider.

Alka-Seltzer products should not be used if you are taking a medicine called a monoamine oxidase inhibitor (MAOI) or for two weeks after stopping the MAOI. An MAOI is a medicine usually used for depression or Parkinson’s disease. If you do not know if your prescription medicine contains an MAOI, ask your health care provider or pharmacist before taking an Alka-Seltzer product. Also tell your health care provider if you are taking a blood thinner (such as warfarin), sedative, tranquilizer, diuretic, or a medicine for gout, arthritis, or diabetes.

Stop taking Alka-Seltzer if you develop any of the following.

  • Pain, cough, or nasal congestion that gets worse or lasts for five days (children) or seven days (adults)
  • A fever that lasts for three days or gets worse
  • Redness or swelling
  • New symptoms
  • A cough that keeps coming back or happens with a rash or lasting headache
  • Nervousness, dizziness, or sleeplessness
  • Ringing in the ears or hearing loss

Check with a health care provider before using Alka-Seltzer if you have any of the following conditions.

If you are taking an Alka-Seltzer product that contains aspirin, you may be at higher risk of developing Reye’s syndrome (in children and teenagers) and stomach bleeding. If you experience any of the following symptoms of stomach bleeding while taking an Alka-Seltzer product with aspirin, stop taking the medicine and call your health care provider.

  • Dizziness
  • Vomit blood or bloody poop
  • Stomach pain that does not get better

Talk to your health care provider if you are planning on taking Alka-Seltzer while you are pregnant or breastfeeding. It is not recommended to take an Alka-Seltzer product with aspirin in it at 20 weeks or later in your pregnancy without talking to your health care provider first. 

There may be side effects, additional warnings, and interactions with other medicines that are not listed here. These may vary depending on the combination of ingredients in the specific Alka-Seltzer product you are using. Always check the label before taking any Alka-Seltzer product. Talk to a pharmacist or health care provider about your health conditions and other medicines to help determine which Alka-Seltzer products are safe for you.

Use the tables below to help you find the best product to treat your symptoms.

Sinus congestion/pressure, itching, sneezing, runny nose, fever, and pain 

Active ingredients: 

  • Pain/fever reducer: aspirin
  • Antihistamine: chlorpheniramine
  • Decongestant: phenylephrine
ProductAlka-Seltzer Plus Severe Cold PowerFast Fizz Effervescent Tablets
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesSparkling original flavor and orange zest flavor

Cough, fever, and pain

Active ingredients: 

  • Pain/fever reducer: acetaminophen
  • Cough suppressant: dextromethorphan
ProductAlka-Seltzer Plus Cough & Sore Throat FizzyChews Raspberry Flavor Chewable Tablets
Age6 years and older 
FormulationChewable tablet
Dosing FrequencyEvery 4 hours
FeaturesRaspberry flavor

Cough, fever, pain, itching, sneezing, runny nose

Active ingredients: 

  • Pain/fever reducer: acetaminophen
  • Antihistamine: chlorpheniramine
  • Cough suppressant: dextromethorphan
ProductAlka-Seltzer Plus Cold & Flu FizzyChews Orange Flavor Chewable Tablets
Age12 years and older
FormulationChewable tablet 
Dosing FrequencyEvery 4 hours
FeaturesOrange flavor

Cough and chest congestion

Active ingredients: 

  • Cough suppressant: dextromethorphan
  • Expectorant: guaifenesin
ProductAlka-Seltzer Plus Cough & Chest Congestion Maximum Strength PowerFast Fizz Cool Blueberry Pomegranate Flavor Effervescent Tablets
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesCool blueberry and pomegranate flavor

Fever, pain, sinus congestion/pressure, and cough

Active ingredients: 

  • Pain reliever/fever reducer: acetaminophen
  • Cough suppressant: dextromethorphan
  • Nasal decongestant: phenylephrine
ProductAlka-Seltzer Plus Cold & Flu Maximum Strength PowerMax Gels Day
Age12 years and older
FormulationLiquid gel capsule
Dosing FrequencyEvery 4 hours
FeaturesNondrowsy
ProductAlka-Seltzer Plus Sinus Congestion & Pain Maximum Strength PowerMax Gels
Age12 years and older
FormulationGel capsule
Dosing FrequencyEvery 4 hours

Fever, pain, cough, and sinus congestion/pressure

Active ingredients: 

  • Pain reliever/fever reducer: acetaminophen
  • Cough suppressant: dextromethorphan
  • Expectorant: guaifenesin
  • Nasal decongestant: phenylephrine
ProductAlka-Seltzer Plus Severe Cold & Flu Honey Lemon Zest Flavor Mix-In Packets Day
Age12 years and older
FormulationMix-in packet 
Dosing FrequencyEvery 4 hours
FeaturesHoney lemon zest flavor, nondrowsy 
ProductAlka-Seltzer Plus Cough, Mucus & Congestion Maximum Strength PowerMax Gels
Age12 years and older
FormulationGel capsule
Dosing FrequencyEvery 4 hours

Cough, fever, pain, itching, sneezing, runny nose, and sinus congestion/pressure

Active ingredients: 

  • Pain reliever/fever reducer: acetaminophen, aspirin
  • Antihistamine: chlorpheniramine, doxylamine
  • Cough suppressant: dextromethorphan
  • Nasal decongestant: phenylephrine
ProductAlka-Seltzer Plus Severe Cold PowerFast Fizz Citrus Flavor Effervescent Tablets Day
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesCitrus flavor
ProductAlka-Seltzer Plus Severe Cold PowerFast Fizz Lemon Flavor Effervescent Tablets Night
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesLemon flavor
ProductAlka-Seltzer Plus Severe Cold & Flu PowerFast Fizz Citrus Flavor Effervescent Tablets
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesCitrus flavor, strawberry honey flavor
ProductAlka-Seltzer Plus Cold & Flu Maximum Strength PowerMax Gels Night
Age12 years and older
FormulationGel capsule
Dosing FrequencyEvery 4 hours
ProductAlka-Seltzer Plus Severe Cold & Flu Honey Lemon Zest Flavor Mix-In Packets Night
Age12 years and older
FormulationMix-in packet
Dosing FrequencyEvery 4 hours
FeaturesHoney lemon zest flavor
ProductAlka-Seltzer Plus Severe Cold & Cough PowerFast Fizz Citrus Flavor Effervescent Tablets
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesCitrus flavor
ProductAlka-Seltzer Plus Cold & Cough Maximum Strength PowerMax Gels
Age12 years and older
FormulationGel capsule
Dosing FrequencyEvery 4 hours 
ProductAlka-Seltzer Plus Sinus Congestion & Pain Maximum Strength PowerFast Fizz Berry Flavor Effervescent Tablets
Age12 years and older
FormulationEffervescent tablet
Dosing FrequencyEvery 4 hours
FeaturesBerry flavor
ProductAlka-Seltzer Plus Sinus, Allergy & Cough Maximum Strength PowerMax Gels
Age12 years and older
FormulationGel capsule
Dosing FrequencyEvery 4 hours
ProductAlka-Seltzer Plus Cold & Cough Maximum Strength Liquid Gels
Age12 years and older
FormulationGel capsule
Dosing FrequencyEvery 4 hours