Tylenol Precise Products for Joint and Muscle Pain

Medically Reviewed by Ami Ishver, PharmD on October 15, 2025
3 min read

Tylenol Precise products are used to treat muscle or joint pain in specific areas, including the back, shoulders, elbows, legs, hips, knees, ankles, or other small joints.

Tylenol Precise products use ingredients you apply directly to the skin (topical) to give you targeted, penetrating pain relief.

Active IngredientHow It Works
LidocaineBlocks nerve signals that cause you to feel pain, resulting in a numbing effect
MentholStimulates nerves, causing a counterirritation and cooling effect that helps relieve pain
CamphorIncreases blood flow to the area where it is applied; causes both a cooling and warming effect that may reduce pain

There are Tylenol Precise products for adults and children as young as 12 years old.

You may have skin redness, burning, irritation, or itching where you apply certain Tylenol Precise products. Side effects can vary depending on the active ingredients (Camphor, Lidocaine, Menthol) in the specific product you use.

Stop using the medicine if you develop a rash or hives. Get medical help right away if you have signs of a serious allergic reaction, such as trouble breathing or swelling of the face, lips, or throat.

Tylenol Precise products are available in creams and patches you apply to your skin. Do not get Tylenol Precise products in your eyes, and do not swallow the medicine.

Always follow the label of the specific Tylenol Precise product you are using. Some Tylenol Precise products should not be used on wounds or damaged, broken, raw, blistered, or irritated skin. You should also not use a heating pad or tightly bandage the area where you applied certain Tylenol Precise products.

You should not use Tylenol Precise creams in large quantities. If you are using a Tylenol Precise patch, you should only use one patch at a time. Do not leave patches on your skin for more than 12 hours.

Stop using your Tylenol Precise products and contact your health care provider if any of the following apply to you. 

  • Pain gets worse instead of better or lasts more than seven days
  • Pain goes away but then comes back in a few days

There may be side effects, additional warnings, and interactions with other medicines that are not listed here. These may vary depending on the combination of ingredients in the specific Tylenol Precise product you are using. Always check the label before taking any over-the-counter medicine. Do not take more than the recommended dose. Talk to your doctor or pharmacist about your health conditions and other medicines to help determine which products are safe for you.

Tylenol Precise comes in different types, but they all give you targeted, penetrating pain relief. All creams are applied to the skin and come with a mess-free massaging rollerball for easy application.

Main GoalProduct Name (Active Ingredients)
Basic numbing relief that is fragrance-free and dye-freeTylenol Precise Pain Relieving Cream (Lidocaine 4%)
Numbing relief with an instantly cooling sensationTylenol Precise Cooling Pain Relieving Cream (Lidocaine 4%, Menthol 1%)
Numbing relief with a warming sensationTylenol Precise Warming Pain Relieving Cream (Lidocaine 4%)
Pain relief with a calming scent to help you relax before bedTylenol Precise Nighttime Pain Relieving Cream (Camphor 4%, Menthol 1.25%)
Scent-free, thin patch that lasts up to 12 hoursTylenol Precise Pain Relieving Patches