Reversing Fatty Liver Disease

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is a condition where fat builds up in your liver. The good news? It's reversible if caught early. Unlike other liver diseases, MASLD doesn't initially damage the organ, giving you a chance to take action and improve your liver health before it becomes more serious.

Losing excess weight is the most effective way to combat MASLD. Aim to lose 10% of your total body weight, but even a 3%-5% loss can significantly improve liver health. Talk to your doctor about safe weight loss methods, which may include diet changes, exercise routines, weight loss surgery, or medication. Every small step toward a healthier weight benefits your liver.

MASLD often coexists with other health conditions. Addressing these can help reverse liver fat buildup. Keep an eye on and treat conditions like diabetes, high cholesterol, high triglycerides, sleep apnea, polycystic ovary syndrome, hypothyroidism, and hormone deficiencies. Work closely with your health care provider to manage these conditions effectively and improve your overall health.

Your diet plays a crucial role in reversing MASLD. Increase your intake of fruits, vegetables, fish, and high-fiber foods. Limit carbohydrates, sugar, saturated and trans fats, and salt. These changes not only aid weight loss but also directly reduce liver fat. Interestingly, your morning coffee might help too – it may lower liver inflammation, though more research is needed.

Alcohol can increase fat buildup and damage your liver. If you have MASLD, it's best to avoid alcohol entirely. If that's challenging, aim to drink less than one drink per day for women and less than two for men. Be cautious with medications too. Follow dosage instructions for acetaminophen and consult your doctor about NSAIDs like ibuprofen, as they may not be suitable for everyone with liver issues.

Some studies suggest vitamin E may improve liver function in MASLD patients, but the evidence isn't conclusive. If you're considering this supplement, discuss it with your doctor first. It's not suitable for everyone and has been linked to prostate cancer in some studies. Your doctor can help weigh the potential benefits against the risks for your specific situation.

While no drugs are specifically approved for MASLD, resmetirom (Rezdiffra) is approved for treating its advanced stage, MASH. Your doctor might discuss other medications or supplements that could help. Researchers are working on new drugs that may help MASLD. Make sure to get vaccinated against hepatitis A and B and get annual flu shots to protect your liver.