Insect Sting Allergy Treatment

Medically Reviewed by Carol DerSarkissian, MD on July 10, 2025
3 min read

Any of these symptoms or a history of severe allergic reactions (anaphylaxis), even if there are no symptoms:

  • Trouble breathing or wheezing
  • Tightness in the throat or a feeling that the airways are closing
  • Hives
  • Swelling away from the area of the sting, especially swelling of the face, tongue, or hands
  • Hoarseness or trouble speaking
  • Nauseaabdominal pain, diarrhea, cramps, or vomiting
  • Fast heartbeat or pulse
  • Skin that severely itches, tingles, swells, or turns red
  • Anxiety, feelings of faintness, or dizziness
  • Loss of consciousness

Do not hesitate to inject the epinephrine if you are unsure whether the symptoms are allergy-related. It will not hurt the person and could save their life. If the person has an anaphylaxis action plan from a doctor for injecting epinephrine and other emergency measures, follow it. Otherwise, if the person carries an epinephrine shot (it's a good idea to always carry two), do the following:

  • Inject epinephrine if the person is unable to.
  • If the person has a history of anaphylaxis, don't wait for signs of a severe reaction to inject epinephrine.
  • Read and follow patient instructions carefully.
  • Inject epinephrine into the outer muscle of the thigh. Avoid injecting into a vein or buttocks muscles.
  • Do not inject medicine into hands or feet, which can cause tissue damage. If this happens, notify emergency room staff.
  • The person may need more than one injection if there's no improvement after the first. If needed, inject again after 5 to 15 minutes. 
  • Any more than 2 doses of epinephrine should not be given unless it's done under direct medical supervision.
  • A person should always go to the ER after an epinephrine injection, even if the symptoms go away.

Do CPR if the person stops breathing.

Follow Up

  • Make sure that someone stays with the person for 24 hours after anaphylaxis in case of another attack.
  • Report the reaction to the person's doctor. 

 If someone has multiple stings -- particularly on their head or neck -- it’s best to get medical help.

  • Scrape the area with the edge of a credit card or straight edge object to remove it.
  • Don't pinch the stinger or use tweezers -- that can inject more venom.
  • You may have to pull off fire ants and check carefully that you got them all.
  • Ice the area.
  • If you were stung on your arm or leg, elevate it.
  • Remove any tight-fitting jewelry from the area of the sting. As it swells, rings or bracelets might be difficult to remove.
  • It might take 2-5 days for the itching and swelling to subside. Keep the affected area clean to prevent infection.